Publications by authors named "Demis Pitoni"
Article Synopsis
- Inflammatory bowel disease (IBD) encompasses Crohn's disease and ulcerative colitis, which are chronic immune-mediated conditions with unclear origins, hindering the development of new treatments.
- Human endogenous retroviruses (HERVs), making up 8% of the human genome, can influence inflammatory and autoimmune disorders when activated, and their expression is regulated by proteins TRIM28 and SETDB1 involved in immune response.
- A study using real-time PCR found that levels of HERV-H-pol and HERV-K-pol were significantly higher in IBD patients compared to healthy controls, while TRIM28 expression was decreased; these findings suggest that HERVs and TRIM28 may play key roles in IBD pathology,
() infection is a prominent entity within human infectious diseases which cause chronic gastritis, peptic ulcers, gastric malignancies, and extragastric disorders. Its persistent colonization can lead to a systemic inflammatory cascade, potentially instigating autoimmune responses and contributing to the pathogenesis of autoimmune diseases. While the specific etiopathogenesis of inflammatory bowel diseases (IBDs) is still unknown, it is widely recognized that immunological, genetic, and environmental factors are implicated.
View Article and Find Full Text PDFVagus nerve stimulation (VNS) is an accepted therapy for the treatment of refractory forms of epilepsy and depression. The brain-gut axis is increasingly being studied as a possible etiological factor of chronic inflammatory diseases, including inflammatory bowel diseases (IBD). A significant percentage of IBD patients lose response to treatments or experience side effects.
View Article and Find Full Text PDFThe development of nutritional and metabolic abnormalities represents an important burden in patients after liver transplantation (LT). Our study aimed at evaluating the incidence, time of onset, and risk factors for nutritional and metabolic abnormalities in patients after LT. The study was a single-center retrospective study.
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