Publications by authors named "Demirkaya H"

Article Synopsis
  • Cefiderocol is effective against carbapenem-resistant bacteria, but its susceptibility varies based on different interpretive criteria from EUCAST and CLSI.
  • Researchers tested 254 CRK blood isolates and found significant differences in resistance rates to cefiderocol when applying EUCAST versus CLSI criteria.
  • High cefiderocol resistance rates were especially noted among NDM producers using EUCAST guidelines, leading to the recommendation that these criteria should be prioritized for testing until more clinical data is available.
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Article Synopsis
  • Aminoglycosides are important for treating infections caused by carbapenemase-producing bacteria (CPK), but resistance to these antibiotics is rising, primarily due to 16S rRNA methyltransferases (RMTs) often found alongside NDM genes.
  • In a study of 181 invasive CPK isolates, 60% were resistant to amikacin, gentamicin, and tobramycin, with most of the resistant isolates carrying RMTs, particularly ArmA and RmtC.
  • The study found that the resistance is largely linked to specific clonal types, particularly ST2096 and ST14, which are associated with certain carbapenemases and other resistance genes, suggesting that clonal spread is a
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Long lockdowns, food shortages, and the inability to receive basic primary healthcare have aggravated the effects of pandemics. However, most studies have focused on the health problems of the infected people or the measures employed to keep the disease under control. This cross-sectional study focused primarily on the mental health issues of employees.

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Ceftazidime-avibactam exhibits good in vitro activity against carbapenem resistant Klebsiella carrying OXA-48-like enzymes. We tested two hundred unique carbapenem resistant Klebsiella blood stream isolates (71% with single OXA-48-like carbapenemases, including OXA-48, n = 62; OXA-232, n = 57; OXA-244, n = 17; OXA-181, n = 5) that were collected as part of a multicentre study against ceftazidime-avibactam using Etest (bioMérieux, Marcyl'Étoile, France), 10/4 μg disc (Thermo Fisher) and Sensititre Gram Negative EURGNCOL Plates (Lyophilized panels, Sensititre, Thermo Fisher) with the aim of comparing the performances of the Etest and disc to that of Sensititre. Ceftazidime-avibactam MIC was 2/>16 mg/L for the entire collection and was 2/4 mg/L for single OXA-48-like producers.

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Despite substantial studies on COVID-19 and the problems employees face, the association between COVID-19 and resigning jobs has not caught the interest of researchers. Millions have already resigned from their employment, and more are expected to resign. This study aims to investigate the relationship between the demographics of employees, the course of COVID-19, perceived effect of COVID-19 on life (PEoC), fear, entrapment feeling, depression, and quitting the job during the COVID-19 pandemic.

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A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited.

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Neurologic complications after solid-organ transplant reveal a great spectrum of pathologies. Intracranial hemorrhages, cerebral ischemic lesions, infarctions, lymphoproliferative disorders, and infections, including aspergillosis, have been observed after liver transplant. Fungi constitute nearly 5% of all central nervous system infections, mainly occurring in immunocompromised patients.

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This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013.

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