Preliminary evaluation of antiproliferative and apoptotic activities of novel indolin-2-one derivatives.

Indole-based agents are frequently used in targeted or supportive therapy of several cancers. In this study, we investigated the anticancer properties of originally synthesized novel indolin-2-one derivatives (6a-d) against Malignant Mesothelioma, Breast cancer, and Colon Cancer cells. Our results revealed that all derivatives were effectively delayed cell proliferation by inhibiting the ERK1/2, AKT, and STAT3 signaling pathways in a concentration-dependent manner.

The association of hemodynamic markers of right ventricular dysfunction with SII index and clinical outcomes in reduced ejection fraction heart failure.

Heart failure (HF) is a clinical syndrome with various etiologies and presentations. The role of the inflammatory pathway in HF prognosis is not fully understood. We investigated the association between the systemic immune-inflammation index (SII) and HF complicated by right ventricular dysfunction (RVD) and whether the SII is related to compromised hemodynamic volume status.

Should we touch tricuspid valve at the time of LVAD implantation? A young patient series.

Background: The aim of the study is to compare the results of patients who had moderate or severe tricuspid insufficiency (TI) at the time of left ventricular assist device (LVAD) implantation that did not undergo intervention.

Methods: Between October 2013 and December 2019, 144 patients who did not undergo tricuspid valve repair (TVR) during LVAD implantation in our department were included in the study. The patients were divided into two groups according to the TI grade; Group 1: 106 patients (73.

Quercetin protects mouse oocytes against chromium-induced damage in vitro and in vivo.

Background: Chromium (Cr) is a naturally-occurring element that is used in various fields of industry. Humans may be exposed to hexavalent chromium [Cr(VI)], which is one of the stable valence states of the chromium through contaminated soil, air, and water. Exposure to Cr(VI) through contaminated drinking water, soil and air causes various cancers and also fertility problems in animals and humans.

Relationship Between Preoperative NT-proBNP and Postoperative Adverse Events in Patients with Left Ventricular Assist Device.

Background: The aim of this study is to investigate the relationship of preoperative NT-proBNP values with postoperative adverse events in patient left ventricular assist device (LVAD) implantation.

Method: Forty-six patients (35 males; mean age 49.4 ± 12.

Angiotensin receptor neprilysin inhibitor for patients with heart failure and reduced ejection fraction: Real-world experience from Turkey (ARNi-TR).

Objective: Heart failure (HF) is a growing public health problem with high morbidity and mortality. Recently, angiotensin receptor neprilysin inhibitor (ARNi) has emerged as a promising treatment for HF with reduced ejection fraction (HFrEF). Here, we shared our experience with the use of ARNi in HFrEF from multiple centers in Turkey.

Midterm Results of Minimally Invasive Left Thoracotomy Fully Magnetically Levitated Left Ventricular Assist Device Implantation.

The aim of the study is to compare outcomes of the patients who underwent HeartMate3 (HM3) implantation with conventional sternotomy (CS) and minimally invasive thoracotomy technique (MILT). From June 2013 to April 2019, 50 patients who underwent isolated HM3 implantation were included. Patients were divided into two groups according to the operative technique; of 50 patients, 28 were implanted with CS and 22 with MILT.

More continuous flow, better learning? The effect of aortic valve opening in patients with left ventricular assist device.

Purpose: The aim of this study was to analyze neurocognitive function in patients who underwent continuous flow left ventricular assist device (LVAD) implantation.

Material And Method: This cross-sectional study included three groups: LVAD ( = 31), heart failure patients ( = 26), and healthy volunteers ( = 27). The Rey Auditory-Verbal Learning Test (RAVLT), Judgement of Line Orientation Test (JLOT), Trail Making Test (TMT), Stroop Color-Word Interference Test (SCWIT), Verbal Fluency Test (VFT), Symbol-Digit Modality Test (SDMT) were used to assess the neurocognitive functions.

Evaluation of Acquired Thrombocytopenia According to the Balloon-Expandable Versus Self-Expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement.

In patients with severe aortic stenosis, the data about the incidence of acquired thrombocytopenia according to the use of balloon-expandable or self-expandable valves are limited. We investigated the relationship between the post-transcatheter aortic valve replacement (TAVR) thrombocytopenia and the balloon-expandable or self-expandable valves. A total of 127 consecutive patients who underwent TAVR were retrospectively analyzed.

Palladium supported on polypyrrole/reduced graphene oxide nanoparticles for simultaneous biosensing application of ascorbic acid, dopamine, and uric acid.

In this study, we report a facile and effective production process of palladium nanoparticles supported on polypyrrole/reduced graphene oxide (rGO/Pd@PPy NPs). A novel electrochemical sensor was fabricated by incorporation of the prepared NPs onto glassy carbon electrode (GCE) for the simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). The electrodes modified with rGO/Pd@PPy NPs were well decorated on the GCE and exhibited superior catalytic activity and conductivity for the detection of these molecules with higher current and oxidation peak intensities.

Inhaled Iloprost and Oral Sildenafil Combination Therapy: Is it a Chance for Heart Transplant Candidacy?

Background: Severe pulmonary hypertension is a risk factor for mortality, due to increased postoperative right ventricular failure, in a heart transplant patient. Elevated pulmonary vascular resistance (PVR) in heart transplant candidates can be reduced using a left ventricular assist device or medical therapy. This study analysed the effect of inhaled iloprost and oral sildenafil combination therapy (ilo-sil) on pulmonary haemodynamic parameters in patients with secondary pulmonary hypertension.

Effects of continuous-flow left ventricular assist devices on cerebral hemodynamics.

Continuous-flow left ventricular assist devices (LVADs) reduce peak systolic flow, increase diastolic flow, and eliminate pulsatility of circulation. Altered blood flow may lead to a change in end-organ perfusion. Analysis of the flow dynamics of the arteries of end organs, such as the brain, may indicate whether an organ is perfused sufficiently.

Composites of Bimetallic Platinum-Cobalt Alloy Nanoparticles and Reduced Graphene Oxide for Electrochemical Determination of Ascorbic Acid, Dopamine, and Uric Acid.

The ultimate aim of this study is to produce a composite of bimetallic platinum-cobalt nanoparticles and reduced graphene oxide (Pt-Co@rGO) based biosensor for the detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). Those are biologically important molecules with the key functions for the human body. Pt-Co@rGO was synthesized using a microwave-assisted technique and utilized for the production of a highly sensitive and stable electrochemical biosensor.

Magnetic nanocomposites decorated on multiwalled carbon nanotube for removal of Maxilon Blue 5G using the sono-Fenton method.

Herein, multiwalled carbon nanotube-based FeO nano-adsorbents (FeO@MWCNT) were synthesized by ultrasonic reduction method. The synthesized nano-adsorbent (FeO@MWCNT) exhibited efficient sonocatalytic activity to remove Maxilon Blue 5G, a textile dye, and present in a cationic form, in aqueous solution under ultrasonic irradiation. The magnetic nano-adsorbent particles were characterized by high-resolution transmission electron microscopy (HR-TEM), transmission electron microscopy (TEM), Raman spectroscopy and X-ray diffraction (XRD).

Highly sensitive carbon-based nanohybrid sensor platform for determination of 5-hydroxytryptamine receptor agonist (Eletriptan).

Highly sensitive nanosensors such as graphene oxide/ platinum-iridium nanohybrid, carboxylic acid functionalized multiwalled carbon nanotubes (GO/Pt-Ir/MWCNT-COOH) and amine functionalized multiwalled carbon nanotubes (GO/Pt-Ir/MWCNT-NH) modified glassy carbon electrode were developed for the determination of 5-hydroxytryptamine receptor agonist, Eletriptan. Graphene oxide/platinum-iridium nanohybrid was synthesized using sonication method and then characterized by spectroscopic and microscopic methods such as Raman, TEM, HRTEM, XPS, and XRD. The prepared nanohybrids modified on glassy carbon electrodes were well characterized and applied for electrochemical determination of Eletriptan.

Optimization with levosimendan improves outcomes after left ventricular assist device implantation.

Objectives: The aim of this study was to examine the haemodynamic effects of preoperative levosimendan infusion in patients who underwent left ventricular assist device implantation and evaluate the prognoses.

Methods: Between May 2013 and October 2018, 85 adult patients who underwent left ventricular assist device implantation were included; 44 and 41 patients suffered from dilated cardiomyopathy and ischaemic cardiomyopathy, respectively. Patients were divided into 2 groups: group A (58 patients) included those who received levosimendan infusion in addition to other inotropes and group B (27 patients) included those who received inotropic agents other than levosimendan.

Ex situ synthesis and characterization of a polymer-carbon nanotube-based hybrid nanocatalyst with one of the highest catalytic activities and stabilities for the hydrolytic dehydrogenation of hydrazine-borane at room temperature conditions.

In this study, a facile ex situ synthesis of a polyaniline-multiwalled carbon nanotube-based Pt nanocatalyst (Pt@PANI-MWCNT) with an average particle size of 3.18 ± 0.12 nm was performed successfully.

Use of the monodisperse Pt/Ni@rGO nanocomposite synthesized by ultrasonic hydroxide assisted reduction method in electrochemical nonenzymatic glucose detection.

An electrochemical non-enzymatic sensor was developed for the detection of glucose based on an electrode modified with monodisperse platinum-nickel nanocomposites-decorated on reduced graphene oxide (Pt/Ni@rGO) which was synthesized using a new ultrasonic hydroxide assisted reduction method. Because the nanocomposites prepared by using NaOH (OH ligands) are much smaller nanocomposites on the supports compared to the ones without OH ligands. Such a monodisperse Pt/Ni@rGO nanocomposites-based electrode exhibited a high electrochemical activity for electrocatalytic oxidation of glucose in alkaline solution.

Multiwalled carbon nanotube-based nanosensor for ultrasensitive detection of uric acid, dopamine, and ascorbic acid.

A novel multiwalled carbon nanotube (MWCNT) based sensor was fabricated as a highly precise and stable electrochemical sensor. The synthesized sensor which consists of ZnNi bimetallic nanoalloy called the ZnNi NPs@f-MWCNT sensor, have been used for the simultaneous detection of uric acid (UA), dopamine (DA) and ascorbic acid (AA). The ZnNi NPs@f-MWCNT sensor obtained based on the microwave irradiation process, and its characterization was performed by using several physical techniques such as XRD, XPS, TEM, Raman, etc.

Natriuretic Peptides in Clinical Practice.

Natriuretic peptides have long been introduced into clinical practice. These biomarkers have certainly been shown to provide useful information in the diagnosis, prognosis and risk stratification in heart failure and also may have a role in the guidance of heart failure therapy. Although, there are some limitations in using of these markers such as lack of specificity, aging, renal dysfunction or obesity, among the huge number of candidates for heart failure biomarkers, only natriuretic peptides are currently widely used in daily clinical practice in heart failure.

Is it Possible to Implant HeartMate 3 Less Invasively? New Pump, New Approach.

HeartMate 3 (HM3) left ventricular assist device (LVAD) is a compact, intrapericardial, centrifugal flow pump with a fully magnetically levitated rotor and a wide range of operation (2-10 L/min) to accommodate a broad range of clinical needs. We analyzed our experience with Heartware VAD (HVAD) and HM3 implantation through minimally invasive left thoracotomy (MILT) and upper minimal J sternotomy. Between March 2015 and October 2016, 31 patients who underwent LVAD implantation through MILT were included in this study.

Flail Tricuspid Leaflet During the Percutaneous Closure of Post-Myocardial Infarction Ventricular Septal Defect.

• A post-MI ventricular septal defect is a complication of ST-elevation MI. • Iatrogenic tricuspid regurgitations have not been reported after percutaneous closure. • Care should be taken with the degree of tricuspid regurgitation to prevent iatrogenic tricuspid injury.

Highly efficient polymer supported monodisperse ruthenium-nickel nanocomposites for dehydrocoupling of dimethylamine borane.

In the present study, highly effective and reusable monodisperse ruthenium-nickel (Ru-Ni) nanomaterials supported on poly(N-vinyl-2-pyrrolidone) (Ru-Ni@PVP) were synthesized (3.51 ± 0.38 nm) by a facile sodium-hydroxide-assisted reduction method; Ru and Ni reduction in PVP solution was accomplished.

Parameters influencing the physical activity of patients with a history of coronary revascularization.

Introduction And Objective: Coronary artery disease is the leading cause of mortality worldwide. Regular physical activity is part of a comprehensive management strategy for these patients. We investigated the parameters that influence physical activity in patients with a history of coronary revascularization.