Publications by authors named "Demirel Fevzi"
We studied a family with three male individuals across two generations affected by common variable immune deficiency (CVID). We identified a novel missense heterozygous variant (c.2602T>A:p.
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- Chronic spontaneous urticaria (CSU) negatively impacts patients' quality of life, and omalizumab is recommended for cases resistant to antihistamines; the Urticaria Activity Score-7 (UAS-7) measures disease severity.* -
- A study compared the long-term effectiveness and side effects of two doses (150 mg and 300 mg) of omalizumab in 108 CSU patients over 60 months, finding no significant differences in disease scores or adverse events between groups.* -
- The research concluded that starting with a 150 mg dose is adequate for CSU treatment, with an option to increase to 300 mg if needed, offering a potentially safer and more
Background: Venom immunotherapy (VIT) is an effective treatment in the patients at high risk of anaphylaxis or life-threatening systemic reactions due to Hymenoptera venom allergy. But, systemic and large local reactions can be observed, especially during the build-up phase of VIT. We evaluated the safety of conventional and ultra-rush build-up protocols.
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- Nasal irrigation may help improve symptoms in children with intermittent allergic rhinitis (AR) when combined with nasal corticosteroids (NC), focusing on the effects of hyaluronic acid (HA) and normal saline solution (NSS).
- In a 28-day study involving 76 children, different groups received NC alone, NC plus NSS, or NC plus HA, with various nasal symptoms and quality of life measures taken before and after treatment.
- Results showed no major differences in symptom scores or quality of life among the groups, but the HA group did show a significant decrease in nasal airflow resistance, suggesting HA may have some benefits worth exploring further.
Haplotype analysis in a 16-year-old boy with vancomycin-induced DRESS syndrome.
Pediatr Dermatol
November 2019
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but life-threatening multisystem adverse reaction to a medication, with vancomycin being one of the most common cause reported. We present the HLA analysis of a pediatric patient who developed DRESS related to vancomycin and compared the results with the available literature. With further data, the use of pretreatment HLA analysis to prevent vancomycin related DRESS may be a valuable option in the near future.
View Article and Find Full Text PDFBackground/aim: In this study, we aimed to assess the clinical and immunological findings of our patients with common variable immunodeficiency (CVID).
Materials And Methods: We analyzed the records of 31 adult patients with CVID (12 females, 19 males). The patients were classified into clinical and immunophenotypic subgroups for statistical comparisons.
Biological agents seem to have been more effective than classic immunosuppressive drugs; however, the adverse events including the hypersensitivity reactions are the main drawbacks of these drugs. We report a 35-year-old man who was treated with adalimumab for ankylosing spondylitis, had a local reaction on the injection site, and generalized itching with rash at the 62nd dose and repeated desensitizations to him with adalimumab. One month after the reaction, skin prick test was performed with a commercial preparation of adalimumab.
View Article and Find Full Text PDFBackground: We aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population.
Methods: In all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing method was used in molecular genetic analysis.