Optimization of betulinic and ursolic acids and phenolics extraction from endemic Rosa pisiformis using Box-Behnken design in relation to cytotoxic activities.

Despite its important pharmacological bioactivities, betulinic acid is still primarily obtained through extraction from heartwood and bark or synthesized synthetically, with less than 3% efficiency. Our endemic rose species, Rosa pisiformis (Christ.) D.

Chemical composition of the essential oil and -hexane extract of subsp. Boiss., an endemic species of Turkey, and their mosquitocidal activity against dengue vector .

subsp. Boiss. is endemic to Turkey and is a species of the genus L.

Successful treatment of c-kit-positive metastatic Adenoid Cystic Carcinoma (ACC) with a combination of curcumin plus imatinib: A case report.

Adenoid cystic carcinoma (ACC) is an aggressive malignant neoplasm of the secretory glands. Conventional chemotherapy has poor effectiveness against metastatic ACC. Thus, a novel effective therapy is needed against metastatic ACC.

Role of microbial exopolymeric substances (EPS) on chromium sorption and transport in heterogeneous subsurface soils: I. Cr(III) complexation with EPS in aqueous solution.

Chromium (III) binding by exopolymeric substances (EPS) isolated from Pseudomonas putida P18, Pseudomonas aeruginosa P16 and Pseudomonas stutzeri P40 strains were investigated by the determination of conditional stability constants and the concentration of functional groups using the ion-exchange experiments and potentiometric titrations. Spectroscopic (EXAFS) analysis was also used to obtain information on the nature of Cr(III) binding with EPS functional groups. The data from ion-exchange experiments and potentiometric titrations were evaluated using a non-electrostatic discrete ligand approach.

Role of microbial exopolymeric substances (EPS) on chromium sorption and transport in heterogeneous subsurface soils: II. Binding of Cr(III) in EPS/soil system.

Laboratory batch sorption and column experiments were performed to investigate the effects of microbial EPSs isolated from Pseudomonas putida P18, Pseudomonas aeruginosa P16 and Pseudomonas stutzeri P40 on Cr(III) mobility in heterogeneous subsurface soils. Our batch and column results indicate that microbial EPS may have a pronounced effect on Cr(III) sorption and transport behavior depending on system conditions (e.g.

In situ stabilization of chromium(VI) in polluted soils using organic ligands: the role of galacturonic, glucuronic and alginic acids.

Laboratory batch sorption and column experiments were performed to investigate the role of organic ligands such as galacturonic, glucuronic and alginic acids (main constituents of bacterial exopolymeric substances (EPS)) on Cr(VI) uptake and transport in heterogeneous subsurface media. Our batch sorption experiments demonstrate the addition of galacturonic, glucuronic and alginic acids to soils enhances Cr(VI) uptake by soil at pH values <7.7 depending on the concentration of the ligand and pH used.

The effects of excess boron with niacin on Daucus carota L. (carrot) root callus.

Niacin (Nicotinic acid, B3 vitamin) may be involved in reduction of toxic effects of boron by regulating growth metabolism. This study was designed to examine whether external niacin treatment would improve the boron mobility in carrot callus cells or not. The results showed that excess boron caused tracheary inversions in meristematic root tissue, and also a shortage was seen in tracheary lengths with boric acid treatment.

Effect of static electric fields in root cells of Vicia faba (Fabaceae).

Serial electron microscopic sections were prepared from half-ripened meristematic root cells of Vicia faba (Fabaceae) which had been exposed gradually to 700, 1000, 2500, 3500, and 5000 V/m static electric fields during seven days with and without Zn and Cd electrodes. At the end of five weeks, wall loosenings and very small nuclei were observed in those root cells which were exposed to static electric currents from the lower side of the medium without electrodes, while abnormalities in cell formation, e.g.

Evaluation of the effects of Helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: a prospective six-month follow-up study.

Background/aims: H. pylori-induced hyperproliferation of the gastric epithelium may have a critical role in gastric carcinogenesis. H.

Diagnosis of orotracheal aspiration using radionuclide salivagram.

There are two main Nuclear Medicine techniques, the gastroesophageal reflux scintigraphy with late lung imaging and the nuclear salivagram, for diagnosis of pulmonary aspiration. Each of the techniques can document the two different, antegrade and retrograde, routes of pulmonary aspiration. In this report, we presented a patient with recurrent respiratory problems and emphasized the importance of concomitant use of the two techniques in the radionuclide diagnosis of aspiration.

The effect of shear stress on solitary waves in arteries.

In the present work, we study the propagation of solitary waves in a prestressed thick walled elastic tube filled with an incompressible inviscid fluid. In order to include the geometric dispersion in the analysis the wall inertia and shear deformation effects are taken into account for the inner pressure-cross-sectional area relation. Using the reductive perturbation technique, the propagation of weakly non-linear waves in the long-wave approximation is examined.

Waves in initially stressed fluid-filled thick tubes.

In this paper, treating the artery as a thick walled cylindrical shell made of an incompressible, elastic and isotropic material and the blood as an incompressible inviscid fluid, by taking the inertia of the wall into account, the propagation of harmonic waves in an initially stressed tube, filled with an inviscid fluid, is studied. Utilizing inner-pressure-inner-cross-sectional-area relation in the linear momentum equation of the fluid, together with the continuity equation, we obtained two nonlinear equation governing the axial velocity and the cross-sectional area of the tube. Assuming that the dynamical motion superposed on large initial static deformation is small, a harmonic wave type of solution to incremental equations is sought and the dispersion relation is obtained as a function of transmural pressure, axial stretch, thickness ratio and the wave number.

A quasi-linear constitutive relation for arterial wall materials.

In this work, considering that under physiological conditions the arteries are subjected to a large initial static deformation and additional small dynamical displacements are superimposed on this initial field, a Boltzman type of constitutive relation is presented for arterial wall materials. For its simplicity in the analysis, the material under investigation is assumed to be isotropic, incompressible and constitutionally nonlinear in Green deformation tensor but linear in the history of deformation tensor. The numerical values of elastic coefficients are obtained by comparing the analytical results with experiments by Simon et al.

An evolution of pulse speed in arteries.

In this work, treating the artery as a thick-walled cylindrical shell made of an incompressible, isotropic and elastic solid, utilizing the large deformation theory and the stress-strain relation proposed by Demiray (1976b, Trans. ASME Ser. E, J.

A stress-strain relation for a rat abdominal aorta.

Assuming the arterial wall is homogeneous, incompressible, isotropic and elastic, a stress-strain relation has been presented for a rat's abdominal aorta. As an illustrating example, the problem of simultaneous inflation and the axial stretch of a cylindrical artery under physiological loading has been solved and then the material coefficients are determined by comparing theoretical results with the existing experiments. The result indicates that the maximum deviation between the theory and experiment for various pressure levels is 3.

Pulse velocities in initially stressed arteries.

In this short paper, treating the artery as a thick walled cylindrical shell and employing the large deformation theory, an analytical expression for the pulse wave speed is obtained and the effect of lumen pressure and the axial stretch on the wave speed is discussed. Numerical results indicate that although the wave speed increases with inner pressure, it decreases with increasing axial stretch.

Incremental elastic modulus for ventricles in diastole.

Utilizing the formulation of so-called 'small deformations superimposed on a large initial deformation' the incremental pressure modulus of a ventricle in diastole is studied and the explicit expression of it is obtained as a function of intraventricular pressure. In the analysis the ventricular wall material is assumed to be homogeneous, incompressible, isotropic and the stress-strain relation is exponential. The numerical results for a dog left ventricle indicate that above a critical value of inner pressure the incremental pressure modulus increases with increasing intra-ventricular pressure.

On large periodic motions of arteries.

The large, radial periodic motion of an artery subjected to a dynamic inner pressure is studied through the use of finite deformation theory of elastic materials. The artery is assumed to behave as an isotropic, homogeneous and incompressible elastic material. Expressions for intramural pressure and wall stresses are obtained as a function of the large periodic motion.

Large deformation analysis of some soft biological tissues.

Due to physiological structure of most of the soft biological tissues, measurable stresses develop after the specimen has been stretched to many hundreds of percent of its relaxed length. Therefore, the nonlinear stress-strain relations developed for vulcanized rubber cannot be applied to soft tissues, which are constitutionally much more nonlinear than other engineering materials. In this article, using two different elastic models proposed for elastic soft tissues, simple elongation of a cylindrical bar and the inflation of a spherical thick shell, which is deemed to be a model for a left ventricle, are studied and the material coefficients characterizing the elastic model are obtained via comparing theoretical results with existing experiments on tissues.