Front Public Health
September 2024
Introduction: Plague is a zoonotic disease that occurs naturally in specific geographic areas. Climate change can influence the populations of the plague host or vector, leading to variations in the occurrence and epidemiology of plague in animals.
Methods: In this study, we collected meteorological and plague epidemiological data from the plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.
Pasteurella multocida is a zoonotic pathogen causing serious diseases in humans and animals. Here, we report P. multocida from wildlife on China's Qinghai-Tibet plateau with a novel capsular serotype, forming a single branch on the core-genome phylogenetic tree: four strains isolated from dead Himalayan marmot (Marmota himalayana) and one genome assembled from metagenomic sequencing of a dead Woolly hare (Lepus oiostolus).
View Article and Find Full Text PDFEight undescribed alkaloids named corydalisine D-K (1-7), including one isoquinoline benzopyranone alkaloid (1), one benzocyclopentanone alkaloid (2), four benzofuranone alkaloids (3, 4, and 5a/5b) and two protoberberine alkaloids (6 and 7), along with fourteen known ones, were isolated from the Corydalis saxicola. Their structures, including absolute configurations, were unambiguously identified using spectroscopic techniques, single-crystal X-ray diffraction and electron circular dichroism calculation. Compounds 2, 14 and 21 exhibit antiproliferative activity against five cancer cell lines.
View Article and Find Full Text PDFPlague is a typical natural focus disease that circulates in different ecology of vectors and reservoir hosts. We conducted genomic population and phylogenetic analyses of the collected from the 12 natural plague foci in China with more than 20 kinds of hosts and vectors. Different ecological landscapes with specific hosts, vectors, and habitat which shape various niches for .
View Article and Find Full Text PDFWhat Is Already Known About This Topic?: The prevalence of rodent-adapted species has been increasing significantly. However, the specific species carried by (), a large rodent species, and the potential risk it poses to human populations remain unknown.
What Is Added By This Report?: (), associated with human endocarditis, was initially identified in , exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and lungs.
The Altun Mountains are among the most active regions of plague foci of the Qinghai-Tibet Plateau where animal plague is prevalent, whereas only three human cases have been found since 1960. Animal husbandry is the main income for the local economy; brucellosis appears sometimes in animals and less often in humans. In this study, a retrospective investigation of plague and brucellosis seroprevalence among humans and animals was conducted to improve prevention and control measures for the two diseases.
View Article and Find Full Text PDFThis study analyzed the epidemiological characteristics of 3,464 human plague cases and the distribution pattern of 4,968 Yersinia pestis isolates from humans, hosts, and vector insects from 1950 to 2020 among two natural plague foci in Yunnan Province, China. These foci include the Rattus flavipectus plague focus of the Yunnan, Guangdong, and Fujian provinces and the Apodemus chevrieriEothenomys miletus plague focus of the highlands of northwestern Yunnan Province. The case fatality rate for plague in humans was 18.
View Article and Find Full Text PDFIn April 2021, a plague outbreak was identified within one family shortly after emerging from hibernation, during plague surveillance in the plague foci of the Qinghai-Tibet Plateau. A total of five marmots were found dead of near the same burrow; one live marmot was positive of fraction 1 (F1) antibody. Comparative genome analysis shows that few single nucleotide polymorphisms were detected among the nine strains, indicating the same origin of the outbreak.
View Article and Find Full Text PDFIntroduction: The Qinghai-Tibet Plateau is considered the most plague-heavy region in China, and skinning and eating marmots () are understood to be the main exposure factors to plague. is relatively inactive during marmots' hibernation period. However, this case report shows plague infection risk is not reduced but rather increased during the marmot hibernation period if plague exposure is not brought under control.
View Article and Find Full Text PDFFront Cell Infect Microbiol
July 2021
A lytic phage vB_YpPYepMm (also named YepMm for briefly) was first isolated from the bone marrow of a who died of natural causes on the Qinghai-Tibet plateau in China. Based on its morphologic (isometric hexagonal head and short non-contractile conical tail) and genomic features, we classified it as belonging to the family. At the MOI of 10, YepMm reached maximum titers; and the one-step growth curve showed that the incubation period of the phage was about 10 min, the rise phase was about 80 min, and the lysis amount of the phage during the lysis period of 80 min was about 187 PFU/cell.
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