Parameters of TNF receptor co-expression in allergic and autoimmune processes: Differences and diagnostic significance.

The authors used a method quantitative estimation density of TNFR1/TNFR2 on cells by flow cytometry with calibration particles, which allowed them to estimate the absolute number of receptors on cells regardless of the type of flow cytometer. The TNF receptor expression parameters were used to determine their association with the fact of disease and to build diagnostic models. The proposed methodological approach using a combination of flow cytometry and mathematical modeling techniques represents a promising direction for testing the diagnostic and prognostic significance of the studied biomarkers.

The Influence of Severity and Disease Duration on TNF Receptors' Redistribution in Asthma and Rheumatoid Arthritis.

One of the mechanisms of cellular dysfunction during the chronization of immune-system-mediated inflammatory diseases is a change in the profile of expression and co-expression of receptors on cells. The aim of this study was to compare patterns of redistribution of TNF receptors (TNFRs) among patients with different durations of rheumatoid arthritis (RA) or asthma. Subgroup analysis was performed on RA ( = 41) and asthma ( = 22) patients with disease duration<10 years and >10 years and on 30 comparable healthy individuals.

Redistribution of TNF Receptor 1 and 2 Expression on Immune Cells in Patients with Bronchial Asthma.

Background: The co-expression patterns of type 1 and 2 tumor necrosis factor (TNF)-α membrane receptors (TNFR1/TNFR2) are associated with the presence, stage, and activity of allergic diseases. The aim of this study was to assess the expression levels and dynamics of TNFRs on immune cells and to assess associations between their expression and severity of bronchial asthma (BA).

Methods: Patients with severe (n = 8), moderate (n = 10), and mild (n = 4) BA were enrolled.

Formation of immunodeficiency in newborn mice exposed to nicotine during intrauterine development.

Exposure to nicotine during intrauterine development leads to immunodeficiency manifested in inhibition of delayed-type hypersensitivity reaction and reduced number of antibody-producing cells forming in response to sheep erythrocytes in newborn mice. The number of splenic CFU in the bone marrow of newborn mice exposed to nicotine in utero is decreased compared to the control. By contrast, nicotine induced an increase in splenic CFU count in fetal liver.

[Comprehensive sanitary characteristics of work conditions].

Article deals with problems of hygienic evaluation of work conditions as a part of complex hygienic characteristics concerning the intensity and difficulty of work. The system of evaluation was suggested by I.S.

[Polypeptide growth factors and their interrelation with hormones in the blood plasma of patients with primary bone tumors].

A relationship between blood plasma levels of polypeptide growth factors and those of peptide and sex steroid hormones, as assayed radioimmunologically, was studied in 91 patients with bone tumors of various histology and 45 healthy donors. The levels of insulin-like growth factor (IGF-1) and somatotropic hormone were significantly higher in cases of chondrosarcoma and patients suffering osteogenic sarcoma in the late puberal period as compared to controls and cases of fibrous histiocytoma, giant-cell tumor, benign tumors and tumor-like lesions of the bone. The peak levels of IGF-1, somatotropic hormone and insulin were registered in osteogenic sarcoma patients who developed pulmonary metastases either in the course or after the completion of combined treatment.

[Specific prevention of diphtheria in adults in foci of this infection].

The studies demonstrated the immunological and epidemiological effectiveness of a single injection of adsorbed diphtheria-tetanus toxoid with reduced antigen content for adults: intense antidiphtheria immunity in 92.3% of the vaccinees 1-3 months and in 94.5% of the vaccinees 1 year after the injection.

[Effect of dalargin on the content of endorphins, leucine-enkephalin ACTH and corticosterone of the blood of stressed rats].

Stress caused by acute cysteamine duodenal ulcer was induced in Wistar male rats. All the endogenous opioides under study were involved in the stress-reaction mechanism. Protective dalargin (synthetic enkephalin analogue) administration revealed a tendency towards normalization of endorphin, L-enkephalin and ACTH blood levels.

[Energy requirements of railroad bridge assemblers].

A study was made of energy losses in the assemblers engaged in the construction of a railway bridge. It was established that daily energy losses in this vocational group did not exceed 2900 kcal. Basing on the data obtained the authors calculated the requirements of the assemblers for the main foods, vitamins and mineral elements.

[Energy expenditures of operators of mechanized columns in the construction of the Baikal-Amur mainline].

Basing on the study of the daily time and energy metabolism budgets in various types of production and non-production activities it has been established that in summer the daily energy consumption in the drivers of mechanized columns amounts to not more than 3200 kcal, being equal to 3500 kcal in winter. These data form the basis of the determination of energy and food requirements of the group of workers under consideration.

[Energy expenditures of the workers on the Baikal-Amur mainline engaged in cutting the Baikal tunnel].

Energy requirements for the tunnel drivers have been established as following: of borers 3062 kcal, operators of the rock loader pnb-3K 3114 kcal, of drivers during drilling bore holes by manual perforator, installation of anchors and nets--3147 kcal, auxillary workers of the rock loader pnb-3K 3267 kcal, of drifters during rock and face cleansing-3540 kcal. According to these data recommendations for energy and food requirements for the above occupational groups have been developed.

[Energy metabolism and the requirement for food and energy in Baikal-Amur mainline workers engaged in clearing strips through the forest].

Indirect calorimetry and time studies showed the diurnal energy expenditure in wood fellers to be 5186.2, in their helpers--4476.9 and in branch choppers--5246.