[Multicenter experience of using Fortelyzin during staged reperfusion therapy of acute ischemic stroke in anterior circulation].

Objective: To evaluate the safety and efficacy of Fortelyzin in the performance of staged reperfusion therapy for acute ischemic stroke (intravenous thrombolytic therapy plus mechanical thrombectomy) in anterior circulation within the FORTA RF multicenter pilot study.

Material And Methods: The study included 72 patients with acute ischemic stroke in anterior circulation, who underwent staged reperfusion therapy in four vascular centers of the Russian Federation from December 2019 to January 2023.

Results: The mean time from illness onset to hospitalization was 94.

[Contraction (retraction) of blood clots in patients with ischemic stroke].

Aim: To study a possible pathogenetic role of the blood clot contraction and its disturbances in the acute stage of ischemic stroke (IS).

Material And Methods: Using a new instrumental technique to study the dynamics of clot contraction in vitro, the authors have determined quantitative parameters of clot contraction (the extent and rate of contraction, duration of the lag-period) in the blood of 85 patients with acute IS.

Results And Conclusion: The contractile activity of blood clots was substantially reduced compared to the blood of healthy subjects.

[Amantadine sulfate (PK-Merz) in the treatment of ischemic stroke: a clinical-experimental study].

A rat model of big brain ischemia with the middle brain artery occlusion was used for the study of amantadine sulfate (PK-Merz) effect on the expression of Hsp70 measured with immunohistochemical method and Western blot 12 h and 4 days after surgery. The neuroprotective effect of PK-Merz associated with the enhancement of Hsp70 expression in ischemic stroke in rats. To confirm the multivector neuroprotective action of the drug, a comparative study of clinical effectiveness of PK-Merz and magnesium sulfate was carried out in 40 patients (20 patients in each group) in the most acute period of atherothrombotic and cardioembolic strokes.

[The reperfusion therapy of ischemic stroke in the inter regional clinical-diagnostic center of Kasan].

The high-tech methods of diagnostics and treatment of patients with ischemic stroke during the therapeutic window have been introduced in the Inter regional clinical-diagnostic center of Kasan. These are systemic intravenous pharmacological thrombolysis, intra-arterial selective pharmacological thrombolysis, balloon angioplasty with simultaneous stenting of an occlusive vessel. The results obtained indicate that the implication of these techniques allows to increase the effectiveness of treatment of patients with acute cerebral ischemia provided minimization of the preperfusion period, individual approach in the choice of a method of thrombolysis, assessment of the character of occlusive process and specifics of the lesion on MRI, use of neuroprotection.