Advancements in risk stratification and management strategies in primary cardiovascular prevention.

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality worldwide, highlighting the urgent need for advancements in risk assessment and management strategies. Although significant progress has been made recently, identifying and managing apparently healthy individuals at a higher risk of developing atherosclerosis and those with subclinical atherosclerosis still poses significant challenges. Traditional risk assessment tools have limitations in accurately predicting future events and fail to encompass the complexity of the atherosclerosis trajectory.

Dental status and oxidative homeostasis state in patients exposed to occupational vibration: superoxide dismutase and catalase content in oral fluid.

Aim: The aim of the research involved determination of catalase and superoxide dismutase content in oral fluid of patients exposed to occupational vibration depending upon their dental status.

Materials And Methods: The assessment of dental status (DS) and superoxide dismutase (SOD) and catalase (CAT) content in oral fluid (OF) was performed in three groups of patients: control group (n0=129) included the persons exposed to occupational vibration and whose results of combined medical examination excluded the presence of vibration disease (VD); the second (n1=63 patients with VD stage I) and the third (n1=66 patients with VD stage II) groups consisted of the patients, who underwent treatment at the clinical department of the Research Institute of Occupational Hygiene and Occupational Diseases of Kharkiv National Medical University of the Ministry of Health of Ukraine. DS determination was carried out according to the method of K.

Dental status and oxidative homeostasis state in patients exposed to occupational vibration: reduced glutathione content in oral fluid.

Aim: The aim of the research involved determination of reduced glutathione content in oral fluid of patients exposed to occupational vibration depending upon their dental status.

Materials And Methods: The assessment of dental status (DS) and reduced glutathione (RG) content in oral fluid (OF) was carried out in three groups of patients: control group (n=129) included the persons exposed to occupational vibration whose results of comprehensive medical examination excluded the presence of vibration disease (VD); the second group (n=63 patients with the VD stage I) and the third group (n=66 patients with VD stage II), who underwent treatment at the clinical department of the Research Institute of Occupational Hygiene and Occupational Diseases of Kharkiv National Medical University of the Ministry of Health of Ukraine. DS determination was carried out according to the method of K.

Informativeness of structural and biochemical changes in the muscle tissue of myocardium in the early postmortem period.

Unlabelled: Postmortem structural and biochemical changes in the muscle tissue (MT) of myocardium from the positions of forensic examinations (FE) of the prescription of death coming (PDC) were not studied systematically, this fact determining the purpose of the present research.

Aim: The aim of the research consisted in study of structural and biochemical changes in the tissue of myocardium during the early postmortem period (PMP).

Materials And Methods: The muscle tissue of myocardium within the early PMP (3-13 hours) after the coming of death was studied on 30 human corpses.

The nomogram technique for determining the prescription of death coming by the content of acid phosphatase in the muscle tissue.

Unlabelled: Criminologists and medical examiners in practice are interested in the existence of reliable, stable criteria that would allow to unambiguously interpret certain post-mortem phenomena observed in the body, and which would allow to determine the age of death.

Aim: The aim of the study was to study the postmortem patterns of acid phosphatase in muscle tissue (MT) of various types to improve the accuracy of determining the age of death.

Materials And Methods: Determination of acid phosphatase content is performed in homogenates of myocardial, esophageal, diaphragm and intercostal muscles in the early postmortem period (PMP) (3-13 hours after death) in 30 human corpses.

The content of lactate in muscle tissue of different types in the early post-mortal period.

Unlabelled: It's known from the basics of clinical biochemistry and pathophysiology, lactate is the end product of anaerobic glycolysis. During exercise lactate leaves the muscles and is converted by the liver into pyruvate or metabolized by brain tissue and heart muscle. The level of lactate in muscle tissue from the standpoint of forensic examination to determine the age of death (PDC) during the early postmortem period (PMP) has not been previously studied.

Lipofuscin content in the muscle tissue during the early postmortem period: improvement of forensic diagnosis of the prescription of death coming.

Unlabelled: Forensic medicine is naturally supported by fundamental sciences, its integration with them contributing to its improvement on the whole, particularly in diagnosis of the prescription of death coming. Scientific achievements and foreign specialists in forensic medicine during recent years have made it possible to significantly deepen our sound knowledge of postmortem phenomena.

Aim: The aim of the research consisted in study of postmortem regularities in the content of lipofuscin in different types of the muscle tissue (MT) for improving accuracy of determination of prescription of death coming.

A complex of regional ecological and medico-social factors: evaluation of dysplastic dependent pathology of the bronchopulmonary system.

Unlabelled: Respiratory diseases are becoming one of the most widespread threats to the world's population. It is important to focus on new public health management mechanisms for the development and promotion of public health at the national and municipal levels. Dysplastic dependent pathology (DDP) of the bronchopulmonary system (BPS) is a group of diseases or conditions, which includes bronchopulmonary dysplasia (BPD), recurrent bronchitis, chronic bronchitis, obliterating bronchiolitis, interstitial lung disease.

The dynamics of changes in biochemical markers of the state of tissue in intercostal muscles during the early postmortem period.

Aim: The aim of study was to evaluate structural and biochemical changes in the tissue of intercostal muscles during the early postmortem period (PMP) - 3-13 hours.

Materials And Methods: Absolute and relative values of the concentration of glycogen, acid phosphatase, lactate, lactate degydrogenase, lipofuscin and cholinesterase during the early PMP were determined on 30 human corpses by results of study of the tissue of intercostal muscles.

Results: It was proved that the early PMP was characterized by proper biochemical and biophysical changes of the muscular tissue, the most demonstrative of them were as follows: a reduction in the concentration of glycogen and dynamic increases in the concentrations of lactate dehydrogenase and lipofuscin.

Study of structural and biochemical changes in the muscular tissue of the oesophagus for solving the problem of diagnosing the prescription of death coming.

Unlabelled: The modern practice and tactics of forensic medical diagnosis require scientific substantiation of informative diagnostic criteria for assessing the prescription of death coming (PDC), first of all during the early postmortem period (PMP).

Aim: The aim of the study was an evaluation of the concentration changes of biochemical markers (BCM) in muscular tissue (MT) of the oesophagus during the early postmortem period.

Materials And Methods: MT of the oesophagus within the period of 3-13 hours after the coming of death was studied on 30 human corpses.

IMPROVEMENT OF TREATMENT IN PERSONS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS.

The aim of study was the optimization of treatment in patients with arterial hypertension and coexistent type 2 diabetes mellitus. The study involved 96 persons with arterial hypertension and type 2 diabetes mellitus (2 of them were excluded). Patients with arterial hypertension and type 2 diabetes mellitus (n=94) were divided in two subgroups: persons from the first (n=54) were treated by telmisartan 40-80 mg/day; second (n=40) - by lisinopril 10-20 mg/day.

[Application of "reytoil" in prevention of atherosclerosis in diabetes patients].

The paper was conducted sonographic study of extracranial atherosclerotic vascular changes in patients with diabetes mellitus, and lipid profile study of the dynamics under the influence of treatment with the inclusion of the drug "Reytoil". Structural changes of the vascular wall correlates with changes of lipid profile in patients with diabetes. Structural assessment of intima-media complex (IMC) can be used as a marker for early diagnosis of vascular remodeling in patients with diabetes, as well as the criterion of efficiency of a treatment.

[Structural and functional changes of cell membranes in patients with renocardiac chronic syndrome].

The 53 patients with chronic renocardiac syndrome, with hypertension in chronic kidney disease, were investigated. In the presence of chronic renal failure there is a decrease of cholesterol in the membrane, which is the basis for the violation liquid characteristics of cell membranes. Changes in the exchange of phospholipids and an increase in the exchange rate reflect increasing phosphatidylcholine lipid peroxidation, increasing in chronic renal failure.

[Activation of lipid peroxidation in patients with renal hypertension].

The study involved 53 patients with arterial hypertension in chronic kidney disease (chronic glomerulonephritis (CGN)). Lipid peroxidation was studied based on the content of diene conjugates and malondialdehyde. Protein peroxidation was studied based on the content of 2,4-dinitphenyl-aldogidrazons.

[Drug with a high metabolic activity, cocarnit, in the treatment of diabetic cardiac autonomic neuropathy].

Left ventricular diastolic dysfunction in patients with diabetes is formed in the absence of atherosclerotic changes as a consequence of diabetic cardiac autonomic neuropathy in the early stages of diabetes. Progression of autonomic cardiac neuropathy in cardio-vascular type is associated with the violation of energy supply of cells, protein synthesis, electrolyte exchange, the exchange of trace elements, oxidation reduction processes, oxygen-transport function of blood, so that metabolic therapy is carried out to optimize the processes of formation and energy costs. The drug cocarnit activates processes of aerobic oxidation of glucose, as well as providing regulatory influence on the oxidation of fatty acids.