Publications by authors named "Demidmaa R Tuvdendorj"

Exercise has been proposed to increase serum testosterone concentrations. The analysis of existing literature demonstrates a large degree of variability in hormonal changes during exercise. In our manuscript, we summarized and reviewed the literature, and concluded that this variability can be explained by the effect of numerous factors, such as (a) the use of different types of exercise (e.

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Aims: To examine whether addition of amlodipine (5 mg)/atorvastatin (10 mg) A/A to Therapeutic Lifestyle change intervention (TLC) would beneficially modulate Metabolic Syndrome (MetS) and oxidized low-density lipoprotein (Ox-LDL) levels.

Methods: Patients with MetS (n = 53) were randomized to TLC + placebo or TLC + A/A for 12 months. Anthropometric measurements, blood pressure (BP), lipid profile, plasma Ox-LDL, and area under the curve of free fatty acid (AUC) during oral glucose tolerance test, a marker of adipose tissue health, were assessed before and after the intervention.

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Article Synopsis
  • The study investigates how a high-fat diet (HFD) affects subcutaneous adipose tissue (scAT) and peripheral blood mononuclear cells (PBMC) over time, using rabbits as a model.
  • Results showed that HFD caused changes in the blood cells of rabbits after 5 weeks, increasing inflammation and contributing to insulin resistance by 10 weeks, but did not significantly alter the scAT's lipid metabolism or inflammation.
  • The findings suggest that targeting the inflammatory responses in PBMC could be crucial for preventing metabolic issues associated with obesity and improving health outcomes.
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Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [C]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of imTGs. However, the extramyocellular TG (emTG) pool, unless precisely excised, contaminates the imTG pool, diluting the imTG-bound tracer enrichment and leading to underestimation of FSR. Because of the difficulty of excising the emTGs precisely, it would be advantageous to be able to calculate the imTG synthesis rate without dissecting the emTGs from each sample.

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