Publications by authors named "Demet Oz"
The current structure-activity relationship of profens (i.e., 2-arylpropionic acid derivatives, a class of non-steroidal anti-inflammatory drugs) discusses the importance of α-monomethyl substitution on these compounds, since the activities obtained through their corresponding arylacetic acid derivatives (i.
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- Hydroxylated 6H-benzo[c]chromen-6-one derivatives (urolithins) are metabolites from ellagitannins found in certain foods and have been linked to cognitive enhancement in Alzheimer's treatment, despite their weak ability to inhibit key enzymes related to the disease.
- A new series of chemical derivatives was specifically created and evaluated for their ability to inhibit acetylcholinesterase and butyrylcholinesterase enzymes, which are important targets in Alzheimer's therapy.
- The synthesized compounds showed biological activity similar to that of established Alzheimer's medications, such as rivastigmine, galantamine, and donepezil, both in laboratory and animal studies.