Immediate Implant Placement After Removal of Maxillary Impacted Canine Teeth: A Technical Note.

Impacted maxillary canine teeth commonly occur in the general population. The traditional therapeutic approach comprises fenestration and orthodontic traction; however, if traction is not feasible or the patient refuses orthodontic treatment, an alternative solution is to remove the impacted tooth and immediately place an implant. This technical note describes a novel surgical approach to rehabilitation after impacted canine tooth removal, entailing immediate placement of a long implant in combination with regenerative materials and a barrier.

Screening for the undiagnosed diabetes at dental chair-side of an Italian university clinic. A pilot prospective study.

Aim: In Italy there is about one undiagnosed case of diabetes for each known case. The dental office might represent an important setting for screening the glycemic status of patients. The aim of the present study was to evaluate the effectiveness of dental chair-side capillary blood sampling for the identification of undiagnosed hyperglycemia in a group of Italian patients.

Mucoceles of the oral cavity: a large case series (1994-2008) and a literature review.

Objectives: Evaluating data of patients affected by oral mucoceles, examined at the Unit of Oral Medicine and Pathology of the University of Milan between January 1994 and December 2008.

Study Design: Concise review on oral mucoceles and analysis of the clinical files of patients who underwent excisional biopsy (patient age, medical history, diagnosis, date and site of the biopsy, histopathological diagnosis and recurrences if any).

Results: During the period June 1994-December 2008, 158 mucoceles were observed (93 males and 65 females), with the most frequent site being the lower lip (53%) (p=0.

Tooth extraction in patients taking intravenous bisphosphonates: a preventive protocol and case series.

Purpose: To test the efficacy of a protocol in preventing the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) after tooth extraction.

Patients And Methods: In this prospective case series, consecutive subjects treated with intravenous bisphosphonates who needed tooth extraction underwent a protocol aimed at reducing the risk of BRONJ, based on local and systemic infection control by means of mechanical and chemical reduction of the local bacterial load plus antibiotic prophylaxis.

Results: We performed 38 extractions in 23 patients treated with intravenous bisphosphonates, mainly zoledronate, for a mean of 17.

Low-grade myofibroblastic sarcoma of the oral cavity.

Two cases of low-grade myofibroblastic sarcoma (LGMS) are presented: one of lateral tongue, the other of lower buccal vestibule. LGMS represents a distinct atypical myofibroblastic tumor that occurs in several sites, primarily within the head and neck regions. A painless, enlarging mass is the most common clinical presentation, but a definitive diagnosis requires both histopathological and immunohistochemical analyses.

An up-to-date view on persistent idiopathic facial pain.

Previously called atypical facial pain, persistent idiopathic facial pain (PIFP) is a common, but poorly defined entity. The cause of PIFP is unknown, but surgery or injury in the distribution of the trigeminal nerve could be reported as early event. Treatment is often unsatisfactory and quality research relating management of this condition is missing.

Localised maxillary ridge expansion with simultaneous implant placement: a case series.

The placement of implants in edentulous areas is often compromised by a thin alveolar crest, which widens the space between the two cortical bones; this offers advantages from aesthetic, biomechanical, and functional points of view. We present our results using the osteotome technique for the creation of a site for an implant, followed by immediate placement of the implant in thin edentulous maxillae, and the stability of the bony expansion over time. Twenty-three patients (six men and seventeen women) with partial edentulism associated with horizontal resorption of the ridges were treated by this technique to obtain a wider bony base for better placement of the implants.

Ability of polyurethane foams to support cell proliferation and the differentiation of MSCs into osteoblasts.

In bone tissue reconstruction, the use of engineered constructs created by mesenchymal stem cells (MSCs) that differentiate and proliferate into three-dimensional porous scaffolds is an appealing alternative to autologous and heterologous bone grafts. Scaffolds considered in this work are represented by polyurethane (PU) foams. Two PU foams (EC-1 and EC-2) were synthesized and characterized for morphology, mechanical properties and in vitro interaction with the osteoblast-like cell line MG63 and MSCs from human bone marrow.

Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study.

Burning mouth syndrome (BMS) or stomatodynia is characterized by a spontaneous burning pain in the oral mucosa without known cause or recognized treatment. This double-blind, randomized, placebo-controlled, single-center study evaluated the effects of systemic Hypericum perforatum extract in patients with BMS. Forty-three patients participated, of whom 39 (35 women, four men, aged 64.

Clinical and histopathological features of the oral mucosa in allogeneic haematopoietic stem cell transplantation patients.

Introduction: Chronic graft-versus-host disease (cGVHD) is a common but serious complication of allogeneic haematopoietic stem cell transplantation (HSCT). Oral involvement of cGVHD occurs in 80 to 100% of patients suffering from cGVHD and may be the early manifestation of this complication.

Aim: To study whether the histological changes of oral cGVHD are detectable in apparently normal oral mucosa of HSCT patients without clinical manifestations of the disease.

Clinical aspect and survival rates in subject with oral cancer: a retrospective cohort study.

Aim: The aim of this study was to describe and evaluate survival in a group of patients with oral malignant neoplasias, observed at the Unit of Oral Pathology and Medicine, University of Milan, between February 1995 and September 2005.

Methods: This retrospective study considered the clinical histories and anamnestic profiles of a group of 108 patients with malignant oral neoplasms. A sample of 72 out of these 108 patients was identified, for whom follow-up data were available for at least 4 months from the date of diagnosis.

Miconazole as adjuvant therapy for oral lichen planus: a double-blind randomized controlled trial.

Background: Topical steroids are the first choice for the treatment of oral lichen planus (OLP). Antifungal drugs are often employed together with them, to prevent secondary oral candidosis, although it has been suggested anecdotally that they can also be beneficial for OLP itself.

Objectives: To compare the effect of clobetasol propionate with and without a topical antifungal drug (miconazole) on the symptoms and extension of OLP.

Oral biopsy. A prospective study on 286 consecutive procedures.

Aim: The aim of the present study was to survey oral biopsy procedures, with particular regard to the incidence of adverse events, patients experience and adequacy of the sample.

Methods: This prospective survey was conducted by collecting detailed information from consecutive patients undergoing oral biopsy; data were obtained on the same day of oral biopsy and after 7 days.

Results: Data on 286 procedures were collected.

Accuracy of referrals to a specialist oral medicine unit by general medical and dental practitioners and the educational implications.

In this study we investigated the accuracy of diagnoses of oral mucosal diseases made by family physicians (without a dental degree), other categories of physicians, and general dental practitioners prior to referring patients to a university oral medicine unit. Over a three-year period, we compared the diagnoses proposed in referral letters with the definitive histological diagnoses made by the specialist unit. Only 305 of 678 (45 percent) of the referral letters included a clinical diagnosis.

Primary small cell carcinoma of the nasal cavity with an unusual oral manifestation.

Small cell carcinoma (SCC) is a malignancy that mainly occurs in the lung, with primary lesions in the head and neck being very rare. This neoplasm has an aggressive growth pattern, high recurrence rate, and tendency to metastasize to other sites via the lymphatics and bloodstream. The prognosis of patients with SCC is poor, as the 5-year survival is only 13%.

The effect of levosulpiride in burning mouth syndrome.

Aim: This paper evaluated the efficacy of the systemic administration of levosulpiride, an antipsychotic and antidepressant drug, in the management of burning mouth syndrome.

Methods: Forty-four subjects suffering from idiopathic burning mouth syndrome were enrolled in the study. Patients underwent a thorough clinical examination, including salivary flow rate measurements, laboratory tests (complete blood cell counts, blood glucose levels, serum iron and transferrin levels, serum vitamin B(12), and folate levels), patch tests for contact allergy to denture materials, and isolation of Candida species from oral mucosal scrapes.

Interventions for treating oral leukoplakia.

Background: Oral leukoplakia is a relatively common oral lesion that in a small but significant proportion of cases changes into cancer. Since most leukoplakias are asymptomatic, the primary objective of treatment should be to prevent such malignant transformation.

Objectives: To assess effectiveness, safety and acceptability of treatments for leukoplakia.

Causative or precipitating aspects of burning mouth syndrome: a case-control study.

Background: On causative or precipitating causes of burning mouth syndrome (BMS), there is a lack of consensus. In this prospective case-control study, we compared clinical features and laboratory aspects to evaluate the association of the proposed causative/precipitating factors of BMS.

Methods: A total of 61 BMS patients and 54 control subjects underwent several evaluations: rest and stimulated salivary flow rates measurements, laboratory tests, isolation of Candida species, assessment of parafunctional activities, detection of anxiety and depression by means of the Hospital Anxiety and Depression Scale.

Burning mouth syndrome: a retrospective study investigating spontaneous remission and response to treatments.

Objective: The aim of this investigation was to evaluate the spontaneous remission rate of burning mouth syndrome (BMS) in a group of subjects suffering from this syndrome.

Subjects And Methods: The medical records of BMS patients attending the Unit of Oral Medicine (1995-2002) were reviewed. The patients with a follow-up period of at least 18 months were then contacted over phone and interviewed using a structured ad hoc questionnaire to record their current symptoms and data about their treatment responses to the therapies.

Osteonecrosis of the jaws in patients treated with bisphosphonates. Review of the literature and the Milan experience.

Aim: A series of 5 patients with osteonecrosis of the jaws possibly related to the use of bisphosphonates is presented. A brief review of the literature is also proposed.

Methods: A retrospective review of patients who received bisphosphonates and who developed osteonecrosis of the jaws following minor oral surgery was performed.

Oral malignancies following HSCT: graft versus host disease and other risk factors.

Allogenic hematopoietic stem cell transplantation (HSCT), a procedure that is widely used in the treatment of a large number of malignant and non-malignant hematological diseases, is still associated with a wide range of complications, one of the most important of which is graft versus host disease (GVHD). The patients undergoing allogenic HSCT are also at high risk of developing secondary neoplasms, particularly leukemias and lymphomas. Solid tumors are less frequent, and the incidence appears to increase over time; the most frequent solid tumors are squamous cell carcinomas.

Squamous cell carcinoma of the oral cavity associated with graft versus host disease: report of a case and review of the literature.

Allogenic peripheral stem cell transplantation (HSCT), a procedure that is widely used in the treatment of a large number of malignant and nonmalignant hematological diseases, is still associated with a wide range of complications, one of the most important of which is graft-versus-host disease (GVHD). The patients undergoing allogeneic HSCT are at high risk of developing secondary neoplasms, particularly leukemias and lymphomas. Solid tumors are less frequent, but their incidence seems to be higher in the patients who develop GVHD; the most frequent solid tumors are squamous cell carcinomas.