Anomalous topological waves in strongly amorphous scattering networks.

Topological insulators are crystalline materials that have revolutionized our ability to control wave transport. They provide us with unidirectional channels that are immune to obstacles, defects, or local disorder and can even survive some random deformations of their crystalline structures. However, they always break down when the level of disorder or amorphism gets too large, transitioning to a topologically trivial Anderson insulating phase.

Non-Hermitian Spectral Flows and Berry-Chern Monopoles.

We propose a non-Hermitian generalization of the correspondence between the spectral flow and the topological charges of band crossing points (Berry-Chern monopoles). A class of non-Hermitian Hamiltonians that display a complex-valued spectral flow is built by deforming an Hermitian model while preserving its analytical index. We relate those spectral flows to a generalized Chern number that we show to be equal to that of the Hermitian case, provided a line gap exists.

Topological Properties of Floquet Winding Bands in a Photonic Lattice.

The engineering of synthetic materials characterized by more than one class of topological invariants is one of the current challenges of solid-state based and synthetic materials. Using a synthetic photonic lattice implemented in a two-coupled ring system we engineer an anomalous Floquet metal that is gapless in the bulk and shows simultaneously two different topological properties. On the one hand, this synthetic lattice presents bands characterized by a winding number.

Unidirectional Modes Induced by Nontraditional Coriolis Force in Stratified Fluids.

Using topology, we unveil the existence of new unidirectional modes in compressible rotating stratified fluids. We relate their emergence to the breaking of time-reversal symmetry by rotation and vertical mirror symmetry by stratification and gravity. We stress the role of the Coriolis force's nontraditional part, induced by a rotation field tangent to the surface.

Symmetry-Protected Multifold Exceptional Points and Their Topological Characterization.

We investigate the occurrence of n-fold exceptional points (EPs) in non-Hermitian systems, and show that they are stable in n-1 dimensions in the presence of antiunitary symmetries that are local in parameter space, such as, e.g., parity-time (PT) or charge-conjugation parity (CP) symmetries.

Superior robustness of anomalous non-reciprocal topological edge states.

Robustness against disorder and defects is a pivotal advantage of topological systems, manifested by the absence of electronic backscattering in the quantum-Hall and spin-Hall effects, and by unidirectional waveguiding in their classical analogues. Two-dimensional (2D) topological insulators, in particular, provide unprecedented opportunities in a variety of fields owing to their compact planar geometries, which are compatible with the fabrication technologies used in modern electronics and photonics. Among all 2D topological phases, Chern insulators are currently the most reliable designs owing to the genuine backscattering immunity of their non-reciprocal edge modes, brought via time-reversal symmetry breaking.

Wavefront dislocations reveal the topology of quasi-1D photonic insulators.

Phase singularities appear ubiquitously in wavefields, regardless of the wave equation. Such topological defects can lead to wavefront dislocations, as observed in a humongous number of classical wave experiments. Phase singularities of wave functions are also at the heart of the topological classification of the gapped phases of matter.

Topological Swing of Bloch Oscillations in Quantum Walks.

We report new oscillations of wave packets in quantum walks subjected to electric fields, that decorate the usual Bloch-Zener oscillations of insulators. The number of turning points (or suboscillations) within one Bloch period of these oscillations is found to be governed by the winding of the quasienergy spectrum. Thus, this provides a new physical manifestation of a topological property of periodically driven systems that can be probed experimentally.

Topological origin of equatorial waves.

Topology sheds new light on the emergence of unidirectional edge waves in a variety of physical systems, from condensed matter to artificial lattices. Waves observed in geophysical flows are also robust to perturbations, which suggests a role for topology. We show a topological origin for two well-known equatorially trapped waves, the Kelvin and Yanai modes, owing to the breaking of time-reversal symmetry by Earth's rotation.

Topological index for periodically driven time-reversal invariant 2D systems.

We define a new Z2-valued index to characterize the topological properties of periodically driven two dimensional crystals when the time-reversal symmetry is enforced. This index is associated with a spectral gap of the evolution operator over one period of time. When two such gaps are present, the Kane-Mele index of the eigenstates with eigenvalues between the gaps is recovered as the difference of the gap indices.

Z2 peak of noise correlations in a quantum spin Hall insulator.

We investigate the current noise correlations at a quantum point contact in a quantum spin Hall structure, focusing on the effect of a weak magnetic field in the presence of disorder. For the case of two equally biased terminals we discover a robust peak: the noise correlations vanish at B = 0 and are negative for B ≠ 0. We find that the character of this peak is intimately related to the interplay between time reversal symmetry and the helical nature of the edge states and call it the Z2 peak.

Magnetic-field-induced localization in 2D topological insulators.

Localization of the helical edge states in quantum spin Hall insulators requires breaking time-reversal invariance. In experiments, this is naturally implemented by applying a weak magnetic field B. We propose a model based on scattering theory that describes the localization of helical edge states due to coupling to random magnetic fluxes.

Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays.

In vitro evaluation of a chemical library of synthetic compounds using two consecutive assays has led to the discovery of fifteen compounds which have the ability to inhibit recombinant Plasmodium falciparum iron superoxide dismutase (PfSOD), suggested as a highly selective target for design of antiparasitic drugs. A large number of compounds were in fact excluded, because they were found to significantly interfere with the components of the assays, thus outlining the drawbacks relative to the use of standard SOD-assays for the research of compounds targeting SODs. The best of the selected compounds showed significant antimalarial activities against two strains of P.

Biochemical and electron paramagnetic resonance study of the iron superoxide dismutase from Plasmodium falciparum.

Recombinant iron-containing superoxide dismutase (Fe-SOD) from Plasmodium falciparum was produced in a SOD-deficient strain of Escherichia coli, purified and characterised. The enzyme is a dimer, which contains 1.7 Fe equivalents and is sensitive to hydrogen peroxide (H(2)O(2)).

Induction of antibodies against the Plasmodium falciparum p126 antigen in non-responder H-2b and partial-responder H-2d mice using synthetic peptides.

The p126 Plasmodium falciparum antigen is processed into two fragments, p50 and p73, the latter one containing the subfragments p47 and p18 when the schizonts rupture. An absence of antibody response against the p126 antigen has been reported recently in H-2b mice and limited to the p73 processed fragment in H-2d mice. Synthetic peptides corresponding to various domains of the molecule have been used to immunize mice in order to overcome the absence of an immune response.

H-2b restriction of the immune response to the p126 Plasmodium falciparum antigen.

Inbred BALB/c (H-2d), CBA (H-2k) and C57B1/6 (H-2b) mice immunized with Plasmodium falciparum schizonts or culture supernates develop antibodies of different antigenic specificities. It has been observed that C57B1/6 mice were unable to produce detectable antibodies against the p126 antigen (native molecule and p73 or p50 processed fragments) compared with other inbred mice. Similar results were obtained using BALB congenic mice with a lack of p126 antibody response in H-2b mice, while H-2d and H-2k mice produced antibodies against the p126.

Immunogenicity of the Plasmodium falciparum serine repeat antigen (p126) expressed by vaccinia virus.

cDNA encoding the serine repeat antigen (SERA) (also called p126) of Plasmodium falciparum has been isolated from the FCR3 strain and inserted into a recombinant vaccinia virus designated vP870. Expression analysis of vP870-infected Vero cells by immunoprecipitation has demonstrated several intracellular forms of SERA and a single secreted SERA peptide. Endoglycosidase digestion of these immunoprecipitated SERA peptides indicated that the intracellular SERA peptides contain simple, high-mannose N-linked oligosaccharides and that the secreted SERA peptide contains complex N-linked oligosaccharides.

Intramolecular mapping of Plasmodium falciparum P126 proteolytic fragments by N-terminal amino acid sequencing.

Protein P126 (also called P140, P113, SERA, SERP1) is a major parasitophorous vacuole antigen of Plasmodium falciparum. This protein is processed upon merozoite release into 2 fragments of 73 kDa (P73) and 50 kDa (P50), which are found in the culture medium. P73 is composed of 2 polypeptides of 47 and 18 kDa linked by disulfide bridges.

Sarcocystis muris (Apicomplexa): a thiol protease from the dense granules.

Homogenates of Sarcocystis muris merozoites (cyst form) and the subcellular fraction of dense granules were assayed for protease activity with substrate-impregnated SDS-polyacrylamide gels. Four acidic and several basic proteases were detected in the merozoites. One of the basic proteases was further characterized as a thiol protease (EC 3.

Immunogenicity and antigenicity of the N-term repeat amino acid sequence of the Plasmodium falciparum P126 antigen.

The P126 protein, a parasitophorus vacuole antigen of Plasmodium falciparum has been shown to induce protective immunity in Saimiri and Aotus monkeys. In the present work we investigated its immunogenicity. Our results suggest that the N-term of P126 is poorly immunogenic and the antibody response against the P126 could be under a MHC restricted control in C57BL/6(H-2b) mice, which could be problematic in terms of a use of the P126 in a vaccine program.

A case of mediastinal teratoma with CT and MRI correlation.

A case of mediastinal teratoma is described with emphasis on its magnetic resonance aspect. All the components of the mass were well defined. The major interest of magnetic resonance imaging in this case consisted in the good delineation of the pericardium and visualization of the absence of pericardial invasion.

[A case of multiple brain calcifications associated with hypoparathyroidism].

We report a case of extensive cerebral calcifications associated with hypoparathyroidism in a 82-year-old woman who has been thyroidectomized and received an antiepileptic treatment for 26 years after an episode of coma followed by confusion. We discuss the frequent confusion in terminology used for describing such cases, emphasizing the necessary distinction between Fahr's disease (extensive cerebral calcifications without abnormal phosphocalcium metabolism) and cerebral calcinosis associated with hypoparathyroidism.

Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum.

Among several protease inhibitors tested, only leupeptin was found to modify qualitatively the processing of P126, a major antigen of the parasitophorous vacuole of Plasmodium falciparum, and to inhibit the release of merozoites. Whereas P126 is normally processed upon merozoite release into 2 polypeptides of 50 and 73 kDa which are discharged in the culture medium, leupeptin treatment led to the recovery of a 56 kDa fragment which was recognized by a monoclonal antibody specific for the 50 kDa polypeptide and of a 73 kDa fragment comigrating with the one obtained in normal culture conditions. Mild trypsinization of the 56 kDa polypeptide gave rise to a 50 kDa product the tryptic fragments of which comigrated with those of the 50 kDa antigen obtained from untreated cultures.

Characterization of a 225 kilodalton rhoptry protein of Plasmodium falciparum.

A monoclonal antibody (24C6 4F12) raised against Plasmodium falciparum culture supernatant antigens gave a multiple dot picture on schizonts when assayed by immunofluorescence on P. falciparum erythrocytic stages. The corresponding antigen was localized in the peduncle of rhoptries by immunoelectronmicroscopy.