Publications by authors named "Delphine S Lemacon"
The protection of DNA replication forks under stress is essential for genome maintenance and cancer suppression. One mechanism of fork protection involves an elevation in intracellular Ca ([Ca]), which in turn activates CaMKK2 and AMPK to prevent uncontrolled fork processing by Exo1. How replication stress triggers [Ca] elevation is unclear.
View Article and Find Full Text PDFUncontrolled resection of replication forks under stress can cause genomic instability and influence cancer formation. Extensive fork resection has also been implicated in the chemosensitivity of "BReast CAncer gene" BRCA-deficient cancers. However, how fork resection is controlled in different genetic contexts and how it affects chromosomal stability and cell survival remains incompletely understood.
View Article and Find Full Text PDFArticle Synopsis
- Nonsense-mediated RNA decay (NMD) is an essential process that degrades faulty mRNAs but its exact mechanisms and implications in health and disease are still being explored.
- A new reporter system and genome-wide CRISPR-Cas9 screening revealed several factors that promote NMD, particularly components of the SF3B complex related to RNA splicing, and highlighted reduced NMD activity in certain cancer-related mutations.
- The study suggests that targeting the NMD pathway could be a promising therapy for myelodysplastic syndromes and cancers with spliceosome mutations, as enhancing RNase H1 levels can help counteract the negative effects of these mutations.