Publications by authors named "Delphine Rolando"
Impaired pancreatic β-cell function and insulin secretion are hallmarks of type 2 diabetes. miRNAs are short, noncoding RNAs that silence gene expression vital for the development and function of β cells. We have previously shown that β cell-specific deletion of the important energy sensor AMP-activated protein kinase (AMPK) results in increased miR-125b-5p levels.
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- Genetic studies are uncovering the molecular mechanisms of type 2 diabetes (T2D) by focusing on variants found in enhancer clusters and super-enhancers specific to certain tissues.
- The researchers created 3D promoter capture Hi-C maps of human pancreatic islets, linking diabetes-related enhancers to their distant target genes and identifying over 1,300 groups of islet enhancers and promoters that form functional 3D hubs.
- These findings suggest that genetic variations within these hubs affect insulin secretion heritability and can be used to develop polygenic scores to predict T2D risk.
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown.
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