Publications by authors named "Delphine Parraud"
Background: This study aimed to demonstrate the utility of the nasal Type I interferon (IFN-I) response as a marker for respiratory viral infections (RVIs) and its potential to enhance diagnosis when combined with first-line PCR tests for Influenza A/B, RSV, and SARS-CoV-2.
Methods: Nasopharyngeal swabs (NPS) from patients at Hospices Civils de Lyon (November 2022-April 2024) suspected of viral infections (n = 788) and from healthy controls (n = 53) were analysed. The IFN-I score was measured using the FILMARRAY® IFN-I pouch prototype, which detects four interferon-stimulated genes.
Article Synopsis
- Qualitative SARS-CoV-2 antigen tests are effective for mass COVID-19 diagnosis but are less sensitive than RT-PCR tests, while quantitative assays have the potential to enhance performance and examine various sample types.
- A study tested 26 patients and found N-antigen present in respiratory, plasma, and urine samples, with RNA only detected in respiratory and some plasma samples.
- The study concluded that urine N-antigen testing could aid in late-stage COVID-19 diagnosis and monitoring, due to its non-invasive nature and the prolonged presence of antigen in urine.
To evaluate the diagnostic performance of the Liaison® Murex anti-HEV IgM and IgG assays running on the Liaison® instrument and compare the results with those obtained with Wantai HEV assays. We tested samples collected in immunocompetent and immunocompromised patients during the acute (HEV RNA positive, anti-HEV IgM positive) and the post-viremic phase (HEV RNA negative, anti-HEV IgM positive) of infections. The specificity was assessed by testing HEV RNA negative/anti-HEV IgG-IgM negative samples.
View Article and Find Full Text PDFRat Hepatitis E Virus: Presence in Humans in South-Western France?
Front Med (Lausanne)
September 2021
Article Synopsis
- Hepatitis E Virus (HEV) is a major cause of hepatitis globally, with high infection rates in South-Western France, particularly linked to Orthohepevirus-A, although some rare cases involve Orthohepevirus-C (HEV-C) from rats.
- In a study screening 224 serum samples mainly from immunocompromised patients in the region, liver function tests showed elevated levels in 63% of cases, with significant anti-HEV IgG and IgM presence.
- Despite the high rates of anti-HEV antibodies, none of the samples tested were positive for HEV-C RNA, indicating that HEV-C is not circulating in South-Western France's human population.