Publications by authors named "Delphine Mouttet-Boizat"
Article Synopsis
- The study explores the effects of locoregional treatments (LRT) like exclusive radiotherapy (ERT), surgery, and a combination of both on overall survival (OS) for patients with de novo metastatic breast cancer (dnMBC).
- It analyzed 4,507 dnMBC patients from 2008 to 2014, focusing on those who had systemic therapy and were alive at least one year post-diagnosis, finding that both ERT and bimodality therapy (BMT) significantly improved OS compared to no LRT.
- The findings suggest that while ERT and BMT were associated with better outcomes, the limitations of observational studies mean that actual benefits might still include unaccounted biases.
Survival Impact of Locoregional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancers in a Large Multicentric Cohort Study: A Propensity Score-Matched Analysis.
Ann Surg Oncol
February 2019
Introduction: Improvement in overall survival (OS) by locoregional treatment (LRT) of the primary tumor in de novo metastatic breast cancer (MBC) patients remains controversial.
Objective: The aim of our study was to evaluate the impact of LRT on OS in a large retrospective cohort of de novo MBC patients, with regard to immunohistochemical characteristics and pattern of metastatic dissemination.
Methods: We conducted a multicentric retrospective study of patients diagnosed with de novo MBC selected from the French Epidemiological Strategy and Medical Economics MBC database (NCT03275311) between 2008 and 2014.
Background: Avoiding axillary lymph node dissection (ALND) for invasive breast cancers with isolated tumor cells or micrometastatic sentinel node biopsy (SNB) could decrease morbidity with minimal clinical significance.
Purpose: The aim of this study is to simulate the medico-economic impact of the routine use of the MSKCC non-sentinel node (NSN) prediction nomogram for ER+ HER2- breast cancer patients.
Methods: We studied 1036 ER+ HER2- breast cancer patients with a metastatic SNB.