Publications by authors named "Delphine Diana Acar"
Monoclonal antibodies (mAbs) hold significant potential as therapeutic agents and are invaluable tools in biomedical research. However, the lack of efficient high-throughput screening methods for single antibody-secreting cells (ASCs) has limited the diversity of available antibodies. Here, we introduce a novel, integrated workflow employing self-seeding microwells and an automated microscope-puncher system for the swift, high-throughput screening and isolation of single ASCs.
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- SARS-CoV-2-neutralizing antibodies (nABs) have shown potential in COVID-19 treatment, but resistant strains have made most existing nABs ineffective, highlighting the need for new cocktails targeting distinct epitopes.
- A discovery program used traditional methods combined with AI predictions to identify two potent nABs, which were validated through animal testing.
- However, structural analysis revealed that the AI predictions were flawed, as both nABs targeted the same binding epitope, emphasizing that experimental validation is crucial in selecting effective nABs.