Publications by authors named "Delphine Cuchet-Lourenҫo"
Clin Exp Immunol
February 2024
Article Synopsis
- Innate immune activity plays a key role in causing intestinal inflammation in Crohn's disease, prompting a need for new molecular targets to manage the disease.
- Inhibitor of apoptosis proteins (IAPs) influence both cell survival and inflammatory signals, and their inhibition using SMAC mimetics (SMs) was tested on immune responses in blood cells.
- The study found that inhibiting IAPs reduced the production of proinflammatory cytokines in response to certain pathogens, suggesting that targeting IAPs could be a promising strategy for developing new treatments for Crohn's disease.
