Publications by authors named "Delphine Cochereau"
Article Synopsis
- This study examined the clinical progression and treatment factors of classic/endemic Kaposi's Sarcoma (KS) by analyzing 160 patients diagnosed between 1990 and 2013.
- It found that 41.2% of these patients required systemic treatment (ST), with key risk factors for ST initiation including long time to diagnosis, type of KS, and lesion characteristics.
- Additionally, there was no significant difference in efficacy between treatment types, suggesting treatment decisions can be made based on the patient's overall health instead of specific medication effectiveness.
Article Synopsis
- Microsatellite instability (MSI) is a cancer-related condition linked to defects in DNA mismatch repair genes, associated with disorders like Lynch syndrome.
- Various cancers, particularly colorectal, endometrial, and gastric, show this MSI phenotype, which is marked by immune system activation and high levels of tumor neo-antigens.
- The text provides an in-depth look at MSI, including its biology, diagnostic techniques, and its role as a predictive biomarker for the effectiveness of immune checkpoint therapy in both colorectal and other types of cancers.
Article Synopsis
- The ESMO/ECC congress happened in Vienna from September 25-29 and focused on new treatments for cancer, especially using the immune system.
- They talked about two main drugs: nivolumab for advanced kidney cancer and atezolizumab for lung cancer and also mentioned other targeted therapies.
- The goal is to improve the care for patients by finding better ways to choose treatments and using simple tests like blood or urine, while also exploring personalized medicine for more tailored cancer treatments.
Article Synopsis
- Methotrexate is the standard treatment for breast cancer patients with meningeal carcinomatosis, but its best schedule has not been established, prompting this study to assess the regimen used at Saint-Louis hospital in Paris.
- The study included 41 patients treated with methotrexate (12 mg/day for 5 days, then 15 mg/week) between 2003 and 2015, with an objective response rate of 54% and a median overall survival of 4 months.
- While this treatment offers a similar overall survival to dose-dense schedules with improved quality of life, a dose-dense approach is still preferred for patients with HER2+ status or significant meningeal progression.
Vaccine knowledge in students in Paris, France, and surrounding regions.
Can J Infect Dis Med Microbiol
May 2014
Introduction: In France, young adults are legally freed from parental authority at the age of 18 years and are, thus, responsible for their own vaccine record. This young adult population is more frequently exposed to vaccine-preventable infectious diseases.
Objective: To determine the factors associated with students' knowledge of the interval between two antitetanus boosters and their report of having up-to-date vaccinations.
We retrospectively analysed two selected patients, referred to our Haematology Department for refractory HTLV-1 associated myositis with circulating pathologic T-cell population with ATL phenotype. They respectively presented also HTLV-1 associated Crohn-like disease and myelopathy. Muscle biopsy of both patients was analysed to determine the pathologic infiltrate.
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