Timing of invasive mechanical ventilation and death in critically ill adults with COVID-19: A multicenter cohort study.

Purpose: To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.

Materials And Methods: The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death.

Severe ARDS Secondary to Pneumonia Requiring VV ECMO in the Setting of Newly Diagnosed Hairy Cell Leukemia.

Venovenous (VV) extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) is initiated in patients with high mortality as a potential lifesaving intervention. Hematologic malignancy (HM) is considered a relative exclusion criterion by the Extracorporeal Life Support Organization (ELSO). This case examines the relative contraindication and presents a successful outcome.

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.

Importance: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established.

Objective: To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality.

Timing of preoperative antibiotic prophylaxis in 54,552 patients and the risk of surgical site infection: A systematic review and meta-analysis.

The aim of the study was to assess the effect of timing of preoperative surgical antibiotic prophylaxis (SAP) on surgical site infection (SSI) and compare the different timing intervals.The benefit of routine use of SAP prior to surgery has long been recognized. However, the optimal timing has not been defined.

Induced labour at term and breech presentation: Experience of a level IIB French maternity.

Unlabelled: Data from the literature on induction of labour in breech presentation are rare and no conclusions can be drawn for this procedure.

Objectives: To evaluate obstetrical and neonatal prognosis following induced labour in breech deliveries at term (37 to 42 weeks of gestation).

Methods: We conducted a single-centre retrospective case-control study in a level IIB maternity unit from 1st January 2012 to 31st December 2015.

[Accuracy of ultrasound estimated fetal weight at term].

Objectives: Our aim was to evaluate the accuracy of estimated fetal weight (EFW) by ultrasound at due date and the factors that could affect it.

Methods: We performed a retrospective study of 233 patients in 2014. An ultrasound was performed at due date consultation around 41 weeks of amenorrhea by midwives sonographer.

Intestinal malrotation complicated by an occlusive syndrome involving internal hernia in a pregnant woman.

We present the case of a 33-year-old female who presented intestinal obstruction at the 7th month of pregnancy. She was complaining of abdominal pain with paroxysms, nausea and vomiting. When the symptoms worsened, we performed a CT-scan, which revealed suspected intestinal obstruction in a context of intestinal malrotation (IM).

Protection of yttria-stabilized zirconia for dental applications by oxidic PVD coating.

In this study, the application of transparent physical vapor deposition (PVD) coatings on zirconia ceramics was examined as an approach to retard the low-temperature degradation of zirconia for dental applications. Transparent monolayers of titanium oxide (TixOy) and multilayers consisting of titanium oxide-alumina-titanium oxide (TixOy-AlxOy-TixOy) were deposited onto standardized discs of 3Y-TZP using magnetron sputtering. Using X-ray photospectroscopy and time-of-flight secondary-ion mass spectrometry, the compositions of the coatings were verified, and an approximate thickness of 50 nm for each type of coating was ascertained.

Importance of perioperative glycemic control in general surgery: a report from the Surgical Care and Outcomes Assessment Program.

Objective: To determine the relationship of perioperative hyperglycemia and insulin administration on outcomes in elective colon/rectal and bariatric operations.

Background: There is limited evidence to characterize the impact of perioperative hyperglycemia and insulin on adverse outcomes in patients, with and without diabetes, undergoing general surgical procedures.

Methods: The Surgical Care and Outcomes Assessment Program is a Washington State quality improvement benchmarking-based initiative.

Involvement of Rho kinase (ROCK) in sepsis-induced acute lung injury.

Indirect acute lung injury is associated with high morbidity and mortality. We investigated the link between Rho kinase (ROCK) activation and apoptotic cell death in sepsis induced acute lung injury. This hypothesis was tested by administering a specific, selective inhibitor of ROCK (Y-27632) to rats subjected to cecal ligation and puncture (CLP).

Lactate: biomarker and potential therapeutic target.

Lactate levels are frequently elevated in critically ill patients and correlate well with disease severity. Elevated lactate levels are prognostic in prehospital, emergency department, and intensive care unit settings. This review discusses the role of lactate as a biomarker in diagnosing and assessing the severity of systemic hypoperfusion, as well as the role of serum lactate measurements in guiding clinical care and enabling prognosis in critically ill patients.

Coating of titanium implant materials with thin polymeric films for binding the signaling protein BMP2.

A fast and simple approach for immobilization using copolymers as interlayers is reported. The synthesized copolymers form stable self-assembled layers on implant materials like, e.g.

[Spontaneous acute intussusception in a pregnant woman].

Acute intussusception in adults is rare and particularly so in pregnant women (between 1 / 5000 and 1 / 68,000 deliveries). It is a life-threatening condition for both the mother and the fetus. In adults, such intussusceptions are mainly secondary to an intestinal disease and frequently a tumour.

Comparison of 30-day outcomes after non-LapBand primary and revisional bariatric surgical procedures from the Longitudinal Assessment of Bariatric Surgery study.

Background: The goals were to compare the morbidity and mortality between primary and revisional bariatric surgery and to identify the clinical predictors of adverse outcomes among patients undergoing revisional surgery in the Longitudinal Assessment of Bariatric Surgery consortium. The study was multi-institutional at university hospitals in the United States.

Methods: Data from the LABS-1 (safety) cohort were analyzed, excluding primary gastric banding patients.

Significance of arterial hypotension after resuscitation from cardiac arrest.

Objective: Expert guidelines advocate hemodynamic optimization after return of spontaneous circulation (ROSC) from cardiac arrest despite a lack of empirical data on prevalence of post-ROSC hemodynamic abnormalities and their relationship with outcome. Our objective was to determine whether post-ROSC arterial hypotension predicts outcome among postcardiac arrest patients who survive to intensive care unit admission.

Design: Cohort study utilizing the Project IMPACT database (intensive care unit admissions from 120 U.

Vascular complication after insertion of a subcutaneous contraceptive implant.

Implanon is a reliable method of contraception widely used in France and around the world. Cases of difficulties encountered in inserting or removing the implant have been described. We report the first case of an insertion accident that led to occlusion of the right brachial artery and required exploratory vascular surgery.

Canadian Association of General Surgeons and American College of Surgeons Evidence Based Reviews in Surgery. 21: the risk of surgical site infection is reduced with perioperative oxygen.

Objective: Does supplemental perioperative oxygen reduce the risk of surgical wound infection after colorectal surgery?

Design: Randomized controlled trial.

Setting: Multicentre trial that included 14 hospitals in Spain.

Patients: 300 patients aged 18-80 years who underwent elective colorectal resection.

UK guidelines for the use of inhaled nitric oxide therapy in adult ICUs. American-European Consensus Conference on ALI/ARDS.

Objective: Although unlicensed, inhaled nitric oxide (NO) therapy is now widely used in the United Kingdom. Our aim was to produce guidelines for the clinical application of inhaled NO in adult intensive care practice, based upon the current level of published information.

Methods: The published data regarding the use of inhaled NO in the acute respiratory distress syndrome and right-sided cardiac failure was presented, analysed and discussed.