Publications by authors named "Dellborg Mikael"
Background: Patients with systemic right ventricle (SRV), either d-transposition of the great arteries following an atrial switch procedure or congenitally corrected transposition of the great arteries, develop severe right ventricular dysfunction, prompting appropriate medical therapy. However, the efficacy of beta-blockers and angiotensin receptor blockers or angiotensin-converting enzyme inhibitors (ACEI) in SRV patients is unproven.
Objectives: The objective of this study was to determine the effects of ACEI/ARB and beta-blockers on outcomes in SRV patients after accounting for likely cofounders affecting their use.
Long-term survival in patients with univentricular heart: A nationwide, register-based cohort study.
Int J Cardiol Congenit Heart Dis
March 2024
Background: Children with univentricular heart (UVH) have a limited life expectancy without early treatment. Long-term survival in UVH, in an unselected nationwide cohort, is unclear.
Objectives: To determine long-term survival in patients with UVH including non-operated patients compared with a control population in Sweden.
Background: The lifetime morbidity burden of patients with Ebstein anomaly (EA) has not been well described.
Methods And Results: Through an extensive 2-country register-based collaboration, patients diagnosed with EA who were born between 1930 and 2017 were identified in Danish and Swedish nationwide medical registries. Each patient was matched by age and sex with 10 control subjects from the general population.
Aims: Patients with congenital heart disease (CHD) have an increased risk of developing acquired cardiovascular diseases. However, the risk of venous thromboembolism (VTE) in patients with CHD is unknown. We aimed to investigate the incidence and risk of VTE in patients with CHD compared with matched controls without CHD.
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- Patients with transposition of the great arteries (TGA) and systemic right ventricle face serious heart-related risks, and researchers sought to determine if specific invasive hemodynamic measures can predict outcomes.
- The study included 242 adults who underwent cardiac catheterization from 1994 to 2020, analyzing various hemodynamic parameters over an average follow-up period of 11.4 years.
- Results indicated that a low aortic pulsatility index (<1.5) strongly predicts negative outcomes such as death or the need for heart transplantation, with the cold/wet hemodynamic profile presenting the highest associated risk.
Article Synopsis
- * Data was collected from Swedish health registries, and the analysis revealed a 5.16 times higher hazard ratio for stroke in patients with both CHD and AF, with even higher ratios in complex CHD cases.
- * The results suggest that younger patients with CHD and AF face a notably increased risk of ischemic stroke, highlighting the need for further research to validate these findings.
Aims: Individuals with congenital heart disease (CHD) are at an increased risk for cancer. As cancer survival rates improve, the prevalence of late side effects, such as heart failure (HF), is becoming more evident. This study aims to evaluate the risk of developing HF following a cancer diagnosis in patients with CHD, compared with those without CHD and with CHD patients who do not have cancer.
View Article and Find Full Text PDFBackground: An association between impaired exercise capacity and risk of mortality has been reported among adults with congenital heart disease (CHD). Over the years, treatment methods have improved and may influence outcome. Hence, we report data from a national cohort reflecting a contemporary population.
View Article and Find Full Text PDFCorrigendum to "Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930-2017)" [The Lancet Regional Health-Europe 18 (2022) 100407].
Lancet Reg Health Eur
May 2024
Article Synopsis
- The text indicates that there is a correction made to a previously published article.
- The article can be identified using its DOI (Digital Object Identifier) number: 10.1016/j.lanepe.2022.100407.
- The correction is likely to address an error or oversight from the original publication.
Article Synopsis
- Patients with congenital heart disease (CHD) have a higher cancer risk and were found to have a lower median age of cancer diagnosis (13 years) compared to non-CHD controls (24.6 years).
- Despite the increased cancer incidence, the overall mortality risk for CHD patients with cancer is not significantly different from that of non-CHD patients when excluding those with genetic syndromes and transplant recipients.
- The most common fatal cancers among CHD patients included unspecified cancers, eye and central nervous system tumors, and blood-related malignancies, with 18.3% of CHD patients diagnosed with cancer ultimately dying from it.
Background: The number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for breastfeeding in women with CHD.
Methods: The data were gathered between 2014 and 2019 and obtained by merging the Swedish Congenital Heart Disease Register (SWEDCON) with the Swedish Pregnancy Register.
Objective: To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD.
Methods: All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched by birth year and municipality to women without CHD (controls) in a 1:5 ratio.
Article Synopsis
- * Analysis was conducted on data from nearly 25,000 CHD patients and over 270,000 controls, revealing a higher incidence of diabetes (8.4% for CHD patients vs. 5.6% for controls) and an increased mortality rate attributed to diabetes in CHD patients.
- * Findings indicate that the risk of diabetes is greater in more recent generations of CHD patients and those with more complex heart defects, highlighting the need for targeted health monitoring and management strategies.
Background: A comprehensive understanding of adult congenital heart disease outcomes must include psychological functioning. Our multisite study offered the opportunity to explore depression and anxiety symptoms within a global sample.
Objectives: In this substudy of the APPROACH-IS (Assessment of Patterns of Patient-Reported Outcomes in Adults With Congenital Heart Disease-International Study), the authors we investigated the prevalence of elevated depression and anxiety symptoms, explored associated sociodemographic and medical factors, and examined how quality of life (QOL) and health status (HS) differ according to the degree of psychological symptoms.
Article Synopsis
- A study examined the survival rates of patients with congenital heart disease (CHD) and Down syndrome (DS) compared to those with CHD without DS and matched controls from the general population.
- Researchers found that patients with CHD-DS had a mortality risk 25 times higher than controls and twice as high as patients with CHD without DS.
- There was a notable improvement in survival for patients with CHD-DS born after 1990, suggesting advancements in congenital heart care may have positively influenced their outcomes.
As more women with congenital heart disease (CHD) are reaching childbearing age, it becomes more common for their symptoms to be evaluated during pregnancy. However, pregnancy-related symptoms are similar to those caused by heart disease. This study investigated the prevalence of factors associated with symptoms during pregnancy in women with CHD.
View Article and Find Full Text PDFPoor maternal self-rated health in healthy women is associated with adverse neonatal outcomes, but knowledge about self-rated health in pregnant women with congenital heart disease (CHD) is sparse. This study, therefore, investigated self-rated health before, during, and after pregnancy in women with CHD and factors associated with poor self-rated health. The Swedish national registers for CHD and pregnancy were merged and searched for primiparous women with data on self-rated health; 600 primiparous women with CHD and 3062 women in matched controls.
View Article and Find Full Text PDFObjectives: This study aimed to determine the status of training of adult congenital heart disease (ACHD) cardiologists in Europe.
Methods: A questionnaire was sent to ACHD cardiologists from 34 European countries.
Results: Representatives from 31 of 34 countries (91%) responded.
Background And Aims: For patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear.
Methods: This multicentre, retrospective cohort study included adults with ccTGA seen at a congenital heart disease centre. Clinical data from initial and most recent visits were obtained.
Article Synopsis
- Low birth prevalence and referral bias complicate the understanding of Ebstein anomaly (EA), particularly concerning its natural history and mortality rates.
- A collaboration between Denmark and Sweden analyzed data from 530 EA patients born between 1970 and 2017, comparing their mortality to 5,300 matched controls over a median follow-up of 11 years.
- The study found that although mortality rates are high for EA patients, those diagnosed more recently showed improved outcomes, especially for cases with isolated lesions, whereas those with severe EA had significantly higher mortality rates compared to the general population.
Article Synopsis
- Mortality rates for pediatric patients with tetralogy of Fallot (TOF) have significantly decreased since surgical interventions began in the 1950s, yet comprehensive survival data in Sweden remains limited.
- This study aimed to analyze survival trends of children with TOF and compare them to similarly matched controls using a nationwide dataset from Sweden spanning nearly five decades.
- The results indicated that of 1,848 patients with TOF, 15.5% died during follow-up, with a notable 10.1% mortality rate in those who underwent surgery, highlighting improved survival rates over different birth periods.
Article Synopsis
- - The study analyzed the risk of recurrent stroke in patients who had transcatheter closure of an atrial shunt (ASCIos) compared to those treated with medication only (ASMed) and matched controls without a history of cerebrovascular events (CVE).
- - Researchers identified 663 ASCIos patients and compared them with the same number of ASMed patients, along with 6,302 matched controls from the general population over a follow-up period of 6.5 years.
- - Results showed similar rates of recurrent stroke between ASCIos and ASMed patients, but the recurrent stroke risk in the ASCIos group was nearly ten times higher than that of matched controls, indicating a concerning outcome for this treatment
Background: Coarctation of the aorta (CoA), a congenital narrowing of the proximal descending thoracic aorta, is a relatively common form of congenital heart disease. Untreated significant CoA has a major impact on morbidity and mortality. In the past 3 decades, transcatheter intervention (TCI) for CoA has evolved as an alternative to surgery.
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