Publications by authors named "Deling Lu"

Article Synopsis
  • Sulfadoxine-pyrimethamine (SP) is crucial for malaria prevention, but parasite resistance poses a challenge, particularly concerning the Pfdhfr and Pfdhps genes associated with SP resistance.
  • A study on 508 P. falciparum isolates from West Africa showed high mutation rates in these genes, with common mutations like Pfdhfr N51I and Pfdhps A437G frequently observed across the region.
  • Despite high resistance, SP may still reduce low birthweight and maternal anemia, highlighting the need for ongoing monitoring of resistance markers to guide effective malaria treatment strategies, especially in pregnant women and infants.
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Visceral leishmaniasis (VL) was widely prevalent in Henan Province in the 1950s. Through active efforts by the government, there were no local cases reported from 1984 to 2015. In 2016, local VL cases reoccurred, and there was an increasing trend of VL cases in Henan Province.

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Background: Historically, malaria due to Plasmodium vivax has been epidemic in Henan Province, China, with Anopheles sinensis as the main vector. The most effective measures to prevent malaria transmission are based on vector control through the use of insecticides. However, insecticides exert a strong selective pressure on mosquito populations for insecticide resistance.

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Article Synopsis
  • Plasmodium falciparum malaria poses a significant health risk globally, leading to research on the PfCSP protein as a potential vaccine target despite its genetic variability affecting vaccine effectiveness.
  • The study analyzed blood samples from 287 Chinese migrant workers returning from Africa, identifying key genetic variations in the PfCSP gene, including notable mutations and a high level of nucleotide diversity.
  • Findings indicated that while certain regions of the PfCSP gene were conserved, others showed signs of positive selection and moderate genetic differentiation between various African populations, providing insights for vaccine development.
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One Health is a collaborative, multi-sectoral, trans-disciplinary approach with the goal of achieving optimal health outcomes by recognizing the interconnection between people, animals, plants, and the environment and determining how this relates to the control of infectious diseases such as malaria, schistosomiasis and so on. Malarias caused by Plasmodium that commonly infects female Anopheles mosquitoes, which feed on human blood and act as a disease vector. It has been a worldwide important public health problem from ancient times.

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Malaria remains a major public health issue in Nigeria, and Nigeria is one of the main sources of imported malaria in China. Antimalarial drug resistance is a significant obstacle to the control and prevention of malaria globally. The molecular markers associated with antimalarial drug resistance can provide early warnings about the emergence of resistance.

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The "1-3-7" approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization (WHO) as an international guideline for malaria surveillance and response in 2018. The "1-3-7" approach was well implemented in Henan Province from 2012-2018. Over this study period, a total of 1,294 malaria cases were detected and reported, and all cases were diagnosed and reported within 1 day with 99.

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Objective: To analyze the epidemiological and clinical data of an imported case of visceral leishmaniasis in Henan Province, and explore the method of laboratory diagnosis of kala-azar.

Methods: The epidemiological and clinical data of an imported visceral leishmaniasis patient were analyzed. bodies in bone marrow smears were observed microscopically.

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Angola was the main origin country for the imported malaria in Henan Province, China. Antimalarial drug resistance has posed a threat to the control and elimination of malaria. Several molecular markers were confirmed to be associated with the antimalarial drug resistance, such as , , , , and This study evaluated the drug resistance of the 180 imported isolates from Angola via nested PCR using Sanger sequencing.

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As indigenous malaria has decreased over recent decades, the increasing number of imported malaria cases has provided a new challenge for China. The proportion of imported cases due to Plasmodium ovale has increased during this time, and the difference between P. ovale curtisi and P.

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Background: Plasmodium ovale has two different subspecies: P. ovale curtisi and P. ovale wallikeri, which may be distinguished by the gene potra encoding P.

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Objective: To retrospectively overview the diagnosis and treatment of malaria during 2010-2014 in Henan Province and understand the role of medical institutions in imported malaria control.

Methods: Information on malaria epidemic situation as well as its diagnosis and treatment during 2010-2014 in Henan Province was collected from the infectious disease surveillance system and information management system for the prevention and treatment of parasitic disease. Descriptive analysis was performed to determine the role of medical institutions in the reporting, diagnosis and treatment of malaria.

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Article Synopsis
  • * Blood tests were performed on over 5 million patients with fever, leading to the capture of over 4,800 Anopheles mosquitoes, primarily Anopheles sinensis.
  • * A significant amount of training was provided to healthcare staff, and 72 areas were recognized as achieving progress towards malaria elimination, with future efforts needed on managing imported malaria cases to prevent resurgence.
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[Malaria situation in Henan Province in 2013].

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi

October 2014

In 2013, 197 cases were reported in Henan Province and all of them were imported cases. Among them, 154 (78.2%) were Plasmodium falciparum cases, 18 (9.

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Objective: To evaluate the capability of malaria parasite detection among professionals from Class III malaria endemic counties of Henan Province in 2012. METHEDS: The capacity assessment of professionals from the Centres for Disease Control and the medical institutions was done in September to December 2012. The content of the assessment included malaria knowledge (including malaria etiology, clinical manifestation, diagnosis, treatment and epidemiology and so on, 100 scores as full marks and 60 as passing score), making blood slides of Plasmodium (4 slides in 1 hour, including Giemsa staining, 40 scores as full marks and 24 as passing score) and identification of species with microscopy (6 slides, 8 min per slide 60 scores as full marks and 36 as passing score).

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