Publications by authors named "Deliang Zhang"

Catalytic materials are considered pivotal in addressing the sluggish kinetics and shuttle effect in lithium-sulfur batteries (LSBs). However, effectively harnessing the utilization rate of active sites within catalytic materials remains a pivotal challenge. In this study, a novel conductive nitrogen-doped graphene-loaded tungsten oxynitride nanoparticle (WNO/NG) with abundant active sites is prepared through a polymer-assisted templating method for serving as a sulfur host.

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Intraoperative surgical margin assessment remains a challenge during breast-conserving surgery. Here, we report a combined strategy of immuno-positron emission tomography (PET) for preoperative detection of breast cancer and guided assessment of margins in breast-conserving surgery through second near-infrared (NIR-II) fluorescence imaging of trophoblastic cell surface antigen 2 (TROP2). We demonstrated that the intensity of PET signals in the tumors was nearly five times higher than in normal breast tissue with a zirconium-89 tracer conjugated to sacituzumab govitecan (SG) in a mouse spontaneous breast cancer model, enabling the identification of tumors.

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Iron regulatory proteins (IRP1 and IRP2) play a pivotal role in maintaining cellular iron homeostasis by binding to iron-responsive elements (IREs) of target mRNAs and regulating the expression of these iron-related genes. Mice and humans that lack functional IRP1 develop erythrocytosis due to erythropoietin overproduction, whereas those that lack IRP2 develop microcytic anemia believed to result from iron deficiency of erythroblasts. Here, we discovered that IRP2 deficiency reduced the expression of hypoxia inducible factor 2 alpha (HIF2a) and its transcriptional target, erythropoietin (EPO), thereby compromising the stress erythropoiesis response to generate RBCs upon anemia.

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Riboflavin transporter 3 (RFVT3) represents a potential cardioprotective biotarget in energetic metabolism reprogramming after myocardial infarction/reperfusion (MI/R). This study investigated the feasibility of noninvasive real-time quantification of RFVT3 expression after MI/R with an radiolabeled probe F-RFTA in a preclinical rat model of MI/R. The tracer F-RFTA was radio-synthesized manually and characterized on the subjects of radiolabeling yield, radiochemical purity, and stability .

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TiCT MXene/CuO composites were prepared by acid etching combined with electrochemical technique. The abundant active sites on the surface of MXene greatly increase the loading of CuO nanoparticles, and the synergistic effect between the different components of the composite can accelerate the oxidation reaction of glucose. The results indicate that at the working potential of 0.

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Nitric oxide (NO) plays a pivotal role as a biological signaling molecule, presenting challenges in its specific detection and differentiation from other reactive nitrogen and oxygen species within living organisms. Herein, a F-labeled (fluorine-18, = 109.7 min) small-molecule tracer dimethyl 4-(4-(4-[F]fluorobutoxy)benzyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate ([F]BDHP) is developed based on the dihydropyridine scaffold for positron emission tomography (PET) imaging of NO .

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Iron regulatory proteins (IRP1 and IRP2) are the master regulators of mammalian iron homeostasis. They bind to the iron-responsive elements (IREs) of the transcripts of iron-related genes to regulate their expression, thereby maintaining cellular iron availability. The primary method to measure the IRE-binding activity of IRPs is the electrophoresis mobility shift assay (EMSA).

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors to replicate its genome and transcribe its genes. Nonstructural protein (nsp) 13 is a helicase required for viral replication. Here, we found that nsp13 ligates iron, in addition to zinc, when purified anoxically.

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Background: Vitamin E (vit E) is an essential nutrient that functions as a lipophilic antioxidant and is used clinically to treat nonalcoholic fatty liver disease, where it suppresses oxidative damage and impedes the progression of steatosis and fibrosis. Mice lacking a critical liver iron-trafficking protein also manifest steatosis because of iron-mediated oxidative damage and are protected from liver disease by oral vit E supplements.

Objectives: We aimed to examine the role of dietary vit E supplementation in modulating iron-sensing regulatory systems and nonheme iron levels in mouse liver.

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Tribological properties depend strongly on environmental conditions such as temperature, humidity, and operation liquid. However, the origin of the liquid effect on friction remains largely unexplored. Herein, taking molybdenum disulfide (MoS) as a model system, we explored the nanoscale friction of MoS in polar (water) and nonpolar (dodecane) liquids through friction force microscopy.

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An AA6061 aluminum alloy tube was fabricated by compacting machining chips via thermomechanical consolidation, including hot pressing and hot extrusion. The microstructure evolution and formation of oxide particles were investigated in correlation to tensile mechanical properties. It was found that fine Al/Mg oxide particles were formed due to the fracture of oxide layers on the chips and the reaction between Mg and AlO during hot extrusion.

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Multiple surface/interface engineering is an effective approach to develop efficient electrocatalysts for promoting the practical application of electrocatalysis and achieving carbon neutrality. Herein, a deep eutectic liquid precursor containing phosphorus was designed. The self-supported three-dimensional (3D) cobalt-doped NiP/NiP nanowire networks coated with a thin layer of carbon (Co-NiP@C) were prepared by using an in-situ one-step pyrolysis method.

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Nanostructured electrocatalysts with unique surfaces and interfaces for hydrogen evolution reaction (HER) are crucial for achieving high performance in universal pH water and natural seawater. Herein, a supramolecular liquid precursor was designed and applied to grow NiCoN/N-doped carbon (NC) ultrathin nanosheet arrays (NiCoN/NC) on carbon cloth through one-step pyrolysis. According to the X-ray absorption spectra, Ni was successfully alloyed into CoN to form NiCoN/NC, which regulates the intrinsic electronic structure and optimizes the adsorption/desorption energy of the catalyst.

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Purpose: Stimulator of interferon genes (STING) protein plays a vital role in the immune surveillance of tumor microenvironment. Monitoring STING expression in tumors benefits the relevant STING therapy. This study aimed to develop a novel F-labeled agonist, dimeric amidobenzimidazole (diABZI), and firstly evaluate the feasibility of noninvasive positron emission tomography (PET) imaging of STING expression in the tumor microenvironment.

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Riboflavin receptor 3 (RFVT3) is a key protein in energetic metabolism reprogramming and is overexpressed in multiple cancers involved in malignant proliferation, angiogenesis, chemotherapy resistance, and immunosuppression. To enable non-invasive real-time quantification of RFVT3 in tumors, we sought to develop a suitable PET probe that would allow specific and selective RFVT3 imaging in vivo. A novel radiofluorinated riboflavin probe (F-RFTA) based on riboflavin was synthesized and characterized in terms of radiochemical purity, hydrophilicity, binding affinity, and stability.

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Riboflavin transporter-3 (RFVT3) is a recently discovered and novel biomarker for the theranostics of nervous system diseases. RFVT3 is significantly overexpressed in cerebral injury after ischemic stroke. Herein, we first reported an RFVT3-targeted tracer I-riboflavin (I-RFLA) for SPECT imaging of ischemic stroke .

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In this study, a series of 4-[(quinolin-4-yl)amino]benzamide derivatives as the novel anti-influenza agents were designed and synthesized. Cytotoxicity assay, cytopathic effect assay and plaque inhibition assay were performed to evaluate the anti-influenza virus A/WSN/33 (H1N1) activity of the target compounds. The target compound demonstrated significant anti-influenza virus A/WSN/33 (H1N1) activity both in cytopathic effect assay (EC = 11.

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We precisely synthesized two-dimensional (2D) PtPdCu nanostructures with the morphology varying from porous circular nanodisks (CNDs) and triangular nanoplates (TNPs) to triangular nanoboomerangs (TNBs) by tuning the molar ratios of metal precursors. The PtPdCu trimetallic nanoalloys exhibit superior electrocatalytic performances to alcohol oxidation reactions due to their unique structural features and the synergistic effect. Impressively, PtPdCu TNBs exhibit a high mass activity of 3.

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SiC/AA2024 nanocomposites with 1 and 5 vol.% SiC nanoparticles have been prepared by a powder metallurgy route involving high-energy ball-milling (HEBM), spark plasma sintering (SPS), and hot extrusion. The microstructures and mechanical properties of the nanocomposite samples before and after T6 heat treatment were investigated.

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Purpose: Efforts have been devoted to select eligible candidates for PD-1/PD-L1 immune checkpoint blocker (ICB) immunotherapy. Here, we have a serendipitous finding of positron emission tomography (PET) imaging tracer 2-[18F]FDG as a potential immunomodulator. Therefore, we hypothesize that 2-[18F]FDG could induce PD-L1 expression change and create an immune-favorable microenvironment for tumor immunotherapy.

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Despite the extensive studies conducted in exploring friction in the aqueous environment, the mechanism of hydration friction remains not well understood. Herein, we directly probed hydration friction on mica-electrolyte interfaces with different hydrated alkali cations through a combination of three-dimensional atomic force microscopy and friction force microscopy. The atomic scale imaging of the hydration layers at the mica surface in different electrolyte solutions clearly revealed a correlation between the alkali cations and the structure of the hydration layers.

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Herein, we report the first Ni-catalyzed enantioselective deaminative alkylation of amino acid and peptide derivatives with unactivated olefins. Key for success was the discovery of a new sterically encumbered bis(oxazoline) ligand backbone, thus offering a de novo technology for accessing enantioenriched - linkages via C-N functionalization. Our protocol is distinguished by its broad scope and generality across a wide number of counterparts, even in the context of late-stage functionalization.

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Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease with poor prognosis. Evidence has shown that vimentin is a key regulator of lung fibrogenesis. Tc-labeled -acetylglucosamine-polyethyleneimine (NAG-PEI), a vimentin-targeting radiotracer, was used for the early diagnosis of IPF, and NAG-PEI was also used as a therapeutic small interfering RNA (siRNA) delivery vector for the treatment of IPF in this study.

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Although KRAS has been an important target for many cancers, direct inhibition of oncogenic RAS remains challenging. Until recently, covalent KRAS G12C-specific inhibitors have been developed and progressed to the clinics. Nevertheless, not all patients benefit from these covalent inhibitors.

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To maintain an adequate iron supply for hemoglobin synthesis and essential metabolic functions while counteracting iron toxicity, humans and other vertebrates have evolved effective mechanisms to conserve and finely regulate iron concentration, storage, and distribution to tissues. At the systemic level, the iron-regulatory hormone hepcidin is secreted by the liver in response to serum iron levels and inflammation. Hepcidin regulates the expression of the sole known mammalian iron exporter, ferroportin, to control dietary absorption, storage and tissue distribution of iron.

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