Publications by authors named "Deliang Gong"
Osteosarcoma (OS) is a heterogeneous malignant spindle cell tumor that is aggressive and has a poor prognosis. Although combining surgery and chemotherapy has significantly improved patient outcomes, the prognosis for OS patients with metastatic or recurrent OS has remained unsatisfactory. Therefore, it is imperative to gain a fresh perspective on OS development mechanisms and treatment strategies.
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- Osteosarcoma is a common cancer in children with a poor outlook; researchers developed five predictive models using super-enhancer-related genes to better understand prognosis and treatment.
- The study found that these gene signatures correlate with the effectiveness of chemotherapy and revealed that the TNFRSF11B gene plays a crucial role in osteosarcoma's cell growth and spread.
- Targeting TNFRSF11B with a specific inhibitor showed promise in reducing osteosarcoma growth, suggesting the potential use of super-enhancer-related genes for improving treatment strategies.
Article Synopsis
- - Osteosarcoma (OS) is a serious bone cancer predominantly seen in children and adolescents, with survival rates showing little improvement over time; the study investigates the impact of tumor-associated macrophages (TAMs) on patient prognosis.
- - Researchers identified seven subtypes of TAMs, with a focus on proangiogenic TAMs (Angio-TAMs) which were linked to significant survival differences among OS patients, and developed a prognostic model using eight associated genes.
- - The study found that patients with high Angio-TAM scores had shorter survival times, and this gene signature could serve as a potential biomarker and target for new therapies in treating osteosarcoma.
Osteosarcoma (OS) is a frequent primary malignant bone tumor, with a poor prognosis. Necroptosis is strongly correlated with OS and may be an influential target for treating OS. This study's objective was to establish a necroptosis-related gene (NRG) prognostic signature that could predict OS prognosis and guide OS treatment.
View Article and Find Full Text PDFOsteosarcoma is a primary malignant tumor found mainly in teenagers and young adults. Patients have very little long-term survival. controls tumor initiation and progression by regulating the expression of its target genes; thus, constructing a risk signature of osteosarcoma target gene set will benefit the evaluation of both treatment and prognosis.
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