Increase in aortic pulse wave velocity is associated with abnormal postprandial triglyceride response.

Background: Aortic pulse wave velocity (aPWV), an index of aortic distensibility, and postprandial hypertriglyceridemia are recognized as independent cardiovascular risk factors.

Hypothesis: The aim of this study was to evaluate the relationship between postprandial hypertriglyceridemia and changes in aPWV.

Methods: We prospectively studied 45 patients (mean age 48 [14] years, 28.

The effect of co-administration of simvastatin and alcohol in rats.

Introduction: The effect of chronic co-administration of alcohol (Alc) and lipid-lowering drugs on hepatic function has not been extensively evaluated. We studied the effects of administering Alc together with a 3-hydroxy-3 methylglutaryl coenzyme A reductase inhibitor [simvastatin (S)].

Materials And Methods: Male Wistar rats (8 weeks old) were randomized and divided into 4 groups of 10 each.

Effect of baseline levels on response of high-density lipoprotein cholesterol to hypolipidemic treatment.

The response of high-density lipoprotein cholesterol to hypolipidemic monotherapy with diet, statins, fibrates, or nicotinic acid was investigated prospectively in 801 patients with dyslipidemia. We hypothesized that the behavior of high-density lipoprotein cholesterol after treatment would depend on its baseline levels and the therapy used.

The epsilon 2 and 4 alleles of apolipoprotein E and ischemic vascular events in the Greek population--implications for the interpretation of similar studies.

The authors investigated whether apolipoprotein (apo) E polymorphism has an allelic and/or genotypic impact on the risk of an ischemic vascular event (IVE) in Greek patients with cardiovascular diseases (CVD). They compared apo E polymorphisms in 1) a group of 165 patients with IVE [IVE(+)], of whom 107 had survived a myocardial infarction and 58 an ischemic stroke; 2) a group of 165 patients, matched with the first group for age and gender, with angiographically confirmed coronary artery disease but without IVE [IVE(-)]; 3) a group of 240 healthy younger individuals with no family history of CVD. The apo epsilon2 allele was 5.

Postprandial lipemia in hypertension.

Objective: Many studies have shown that patients with coronary artery disease have an exaggerated rise and a delayed fall of plasma triglyceride (TG) concentration postprandially. We examined whether patients with essential hypertension have the same response to a fatty meal.

Methods: A fatty meal (350g per 2 m(2) body surface with 83.