[Sentinel lymph node mapping in patients with colorectal cancer].

Unlabelled: The colorectal cancer is the most frequent and clinically significant tumor of the gastrointestinal tract. For more than 100 years, radical lymphadenectomy has been the diagnostic and therapeutic gold standard for the management of metastatic nodal disease. More than 50% of patients are initially present with I and II stage of the disease.

[Pathologic handling and investigation of surgical resected specimen in rectal cancer].

A methodic for pathologic handling and investigation of surgical resection specimen in rectal cancer is presented. It is conformed with recent trends of multidisciplinary approach to rectal cancer. Surgeon is involved in macroscopic investigation of the fresh specimen, whether pathologist is responsible for macroscopic and histological examination of the fixed specimen.

[Rare case of florid vascular proliferation of small intestine complicated with intussusception and bowel obstruction].

Vascular abnormalities of the intestines are unusual. We present a florid benign vascular proliferation of the jejunum in one adult patient, presented with intussusception. In this cases, the proliferation was sufficiently exuberant to raise the possibility of angiosarcoma as a diagnostic consideration.

[The influence of the preoperative radiotherapy upon the pathological characteristic of the rectal cancer].

Unlabelled: The preoperative radiotherapy, leads to the reduction of the tumor, mainly through the destruction of the peripheral, well oxygenized tumor cells. These could change the remoteness of the tumor, from the sphincter and to influence on the type of operation, increasing the share of the conserving surgery. The aim of this study is to determine the frequency of these changes and their influence on the surgical approach.

[Stage migration after biopsy of internal mammary sentinel lymph node in breast cancer patient].

The development of sentinel lymph nodes biopsy rouses a newer interest to internal mammary lymph nodes region. We report a case of internal mammary sentinel lymph nodes biopsy of a woman with breast cancer leaded to stage migration. A 71 years old woman with upper medial quadrant left breast cancer is reported.

[Gastrointesinal stromal tumors--clinical and morphological aspects].

Gastrointestinal Stromal Tumors (GISTs) are uncommon mesenchimal tumors that usually arise in the wall of the gastrointestinal tract. Although heterogenous in morphology, GISTs represent a group of tumors probably originating from the intestinal pacemaker cell, interstitial cell of Cajal. The tumour cell phenotype can be established only when histomorphology is coupled with immunostaining.

[Grading intraductal breast carcinoma].

Mammographic screening has led to increased detection of intraductal carcinoma of the breast (IdC). IdC is y heterogeneous disorder with different clinical outcomes. The study was designed to confirm consensibility of the three-tiered classification, accepted by Thomas Jefferson University Consensus Conference since 1997.

[Reconstructive surgery after mastectomy--the anatomical prerequisites].

Reconstructive surgery of the breast after mastectomy occupies an important place in the complex treatment of breast cancer. The aim of the present study is to determine the capacity of the dermo-muscular flaps and to study the anatomical premises for their use under breast reconstructions. On the base of putrid material are created operative models of reconstructions of the breast with myocutaneous flaps m.

[The treatment of cyclic mastalgia--a comparative study between the preparations Bromocriptine and Geritamin].

The aim of the prospective randomized study was to compare the reduction in cyclical breast pain after treatment with oral bromocriptine for 30 days (42 cases) and Geritamine for 40 days (44 cases). The overall response rate to first group was 78.5% and 64.

[Sentinel lymph node biopsy. The possibilities for axial staging in early breast cancer and the results in 187 patients].

The authors studied the sentinel lymph node (SLN) identification rate and its accuracy in predicting axillary staging (N- or N+) in patients with early breast cancer. One hundred eighty seven mapping procedures were performed using a vital dye (Patent blue V, Drimaren Brilliant blue or Mitoxantrone) injected at the primary tumour site. The overall rate of identification of SLN was 81.

[The TUNEL technic for demonstrating apoptosis on paraffin sections].

TUNEL technique, i.e. terminal deoxynucleotidil transferase-mediated dUTP nick end-labeling, has become a widely used staining method to assist in detection of apoptotic cells in tissue section for routine pathology and scientific investigation.

[The triple diagnosis of breast diseases].

The aim of the study is to assess the data of clinical, mammographic, cytological and triple diagnosis of breast diseases. 188 patients are included in the study. The hystological findings are as follow: 58 patients with carcinoma and 130 with benign diseases.

[Prognostic factors and the risk of axillary metastases in early breast cancer].

The authors analyzed the clinical and pathomorphological of T tumors for their association with the likelihood of axillary metastases. Two hundred forty three patients with early breast cancer (T1N0M0 T1N1M0) were studied. All underwent complete lymph node dissection.

[Regional lymphotropic chemotherapy in breast cancer--a new approach in the therapeutic procedure for the parasternal lymph nodes].

A method of regional lymphotropic chemotherapy in breast cancer is presented, aimed at attaining higher cytostatic concentration in the region of parasternal lymph nodes. In twenty-three women with centrally and medially situated tumors preoperatively 1 mg Mitoxantrone is applied around the 4 tumor poles each. In ten cases (IIb and IIIa stage) given 3 courses of nonadjuvant chemotherapy, part of the Cyclophosphamide dose is administered as regionally lymphotropic subxiphoid bilaterally.

[The lymphotropic marking and biopsy of sentinel lymph nodes in T1 tumors--a new approach to the staging of axillary lymphatic metastasis in breast cancer].

It is the purpose of the study to assay the possibility of demonstrating axillary lymph status through marking and biopsy of sentinel lymph nodes. Preoperative lymphotropic marking of sentinel lymph nodes is performed in 48 female patients presenting mammary gland carcinoma, measuring up to two centimeters. Drimaren 0.

[The adjuvant chemotherapy of N(-) patients with breast cancer--when is it indicated?].

The object of this research is determination the necessity of leading of adjuvant chemotherapy with patients with breast cancer without metastases in axillary lymph nodes (N(-)), with disadvantages other prognostic factors (T > 20 mm, estrogen receptors (-), II and III stage grading). Post-operative with 52 women with high risk of recedives or metastases had been performed polychemotherapy (39-CMF and 13 FEC). Control group include 40 patients without adjuvant chemotherapy.

[Regional and systemic neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri].

Neoadjuvant chemotherapy with bleomycin and Cisplastin was administered on ten patients with cervical cancer (IIB, IIIA, IIIB). On three successive days, five minutes after deep bilateral subcutaneous application of 100E Hylase in the medical surface of the lower third of the shin, 20 mg/msq of bleomycin was introduced slowly. The chemotherapeutic drug was absorbed by the lymph capillaries predominantly, and then transferred to the pelvic lymph nodes.

[The treatment of slowly healing wounds with collagen and growth factors].

Experience had with the local application of collagen and autologous growth factors, isolated from platelets, in 35 patients presenting chronic, slowly healing wounds, treated with conventional methods, is discussed. In 24 cases of the series reviewed the wounds undergo epithelization within six weeks, and in the remainder (11)-within 10 weeks. As shown by the results, the healing process is quicker in wounds of patients treated with growth factors in combination with collagen, as compared to the control group--p(t) > 0.

[Our experience with the surgical treatment of cholelithiasis].

The treatment results in 312 patients with cholelithiasis, covering the period 1989 to 1993, are retrospectively analyzed. Overall postoperative lethality amounts to 4.4 per cent.

[The incorrect positioning of the intestinal stoma as the reason for complications in its care].

The role of the position of intestinal stoma in 81 patients was the subject of a clinical study. In 48 patients the position did not meet the requirements of an optimal position, i.e.

[Smooth-muscle sphincteroplasty in constructing a colostomy].

A method is described for producing continent colostomal by smooth-muscle sphincteroplasty. There are variants of operative technique: autogenic smooth-muscle intestinal grafting and pediculated plasty. A 10 cm long intestinal segment is split along the free tenia, mucosectomized and wrapped around the precolostomal part of the colon.