Effect of body weight and composition on efavirenz, atazanavir or darunavir concentration.

Background: To compare the steady state plasma concentrations (Css) of three antiretroviral drugs in both normal and overweight patients, and to determine the relationship between Css and fat mass (FM) or lean body mass.

Methods: Patients treated for more than 6 months once daily with one of the antiretroviral drugs: efavirenz (EFV) 600mg, atazanavir boosted with ritonavir (ATV-r) 300mg/100mg, or darunavir boosted with ritonavir (DRV-r) 800mg/100mg, combined with two nucleoside analogues, were enrolled prospectively. One at steady state, plasma samples for the assessment of drug concentration were taken and body composition was assessed by bioelectrical impedance.

Pharmacokinetics of salbutamol in the pregnant woman after subcutaneous administration with a portable pump.

Objective: We sought to determine whether subcutaneous administration of salbutamol resulted in plasma levels comparable to those achieved after intravenous or oral administration.

Methods: Twenty-nine women with preterm labor received subcutaneous infusion of salbutamol through a portable pump. We used three different rates of continuous infusion: a low rate of 3.

Relationship between dose, blood level and haemodynamic response in patients with cirrhosis receiving propranolol.

Fifty-two patients with cirrhosis receiving continuous administration of propranolol in doses reducing the heart rate by 25% were studied. The doses and plasma levels varied widely - 185 +/- 98 mg/day (mean +/- SD) and 208 +/- 153 ng/ml, respectively. These values were significantly correlated.

Comparative use of fructose and glucose in human liver and fibroblastic cell cultures.

The effect of fructose as a substitute for glucose in cell culture media was investigated in human skin fibroblast and liver cell cultures. Cells were grown for between 2 and 10 days in identical flasks in four different media, containing 5.5 mmol X 1-1 and 27.

Metronidazole kinetics in patients with acute renal failure on dialysis: a cumulative study.

Nine patients with acute renal failure who were undergoing dialysis at intervals depending on clinical state were injected with metronidazole, 7.5 mg . kg-1 iv every 8 hr.

Assessment of beta-adrenergic blockade with propranolol in patients with cirrhosis.

Fourteen patients with cirrhosis and bleeding esophageal varices were treated with propranolol. The dose of propranolol was determined by decreasing the resting heart rate by 25% 12 hr after an oral dose of propranolol which was given twice a day. Significant decreases in the hepatic venous pressure gradient and cardiac output after 1 month of propranolol administration was observed.

Comparative effects of glucose and fructose on growth and morphological aspects of cultured skin fibroblasts.

The growth rate of human skin fibroblasts was evaluated when glucose was replaced by fructose in the culture medium. Four mediums containing respectively 5.5 mmol/l glucose (G1), 27.

Pharmacokinetics of tinoridine after oral administration to healthy subjects and patients with renal failure.

The pharmacokinetics of tinoridine was studied after oral administration (200, 400, and 800 mg in random order) to six healthy subjects and (200 mg) to patients with renal disease. Plasma concentrations of tinoridine were determined by GLC with electron-capture detection and urine concentrations by HPLC. The plasma half-life of tinoridine was about 8.

Influence of two cell harvesting methods on intracellular ATP and amino acid concentrations in human fibroblast cultures.

The intracellular ATP and amino acid concentrations were determined in human fibroblast cultures reaching confluence. The values obtained were very different, depending on the cell harvesting method: trypsinization or scraping. Trypsinization appeared to be the better method for measuring the ATP concentrations (21.

Pharmacokinetics in man of acebutolol and hydrochlorothiazide as single agents and in combination.

The pharmacokinetics of acebutolol and hydrochlorothiazide (HCT) alone or in combination were studied in 12 healthy subjects in a cross over study. Acebutolol and diacetolol (the main metabolite) in plasma and urine were determined by HPLC and hydrochlorothiazide by GLC. The main pharmacokinetic parameters of acebutolol did not differ significantly: AUC 4492 +/- 272 micrograms l-1h given alone versus 4118 +/- 354 micrograms l-1h with HCT, half-life (7,69 +/- 0,32 h vs 8,10 +/- 0,72 h) and renal clearance (13,1 +/- 0,5 lh-1 vs 13,8 +/- 0,9 lh-1), respectively.

The beta-blocking effect of diacetolol in humans and its relationship to plasma levels.

The beta-blocking action of diacetolol was studied in six healthy subjects after oral administration of placebo, 200, 400, and 600 mg diacetol in random order by means of exercise tests. Diacetolol plasma levels were determined by the HPLC method. Drug administration had No significant influence on resting heart rate and resting systolic or diastolic blood pressure.

[Total acid phosphatase. Trials of commercial kits and control sera (author's transl)].

The authors estimated the total serum acid phosphatase activity of human serum and that of ten commercial sera using seven commercial kits. The reproducibility and the average of the results, the value of the control sera are given for these seven commercial kits.