Publications by authors named "Delgado Jimenez Juan"

Renal transplantation improves the survival and quality of life of patients with end-stage renal disease. Cardiovascular disease is the leading cause of morbidity and mortality in renal transplant recipients. The bidirectional relationship between renal and heart disease creates a unique clinical scenario that demands a comprehensive and personalized approach.

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Introduction And Objectives: Our aim was to describe the characteristics and outcomes of heart transplants in Spain.

Methods: We analyzed trends in recipient and donor characteristics, recipient-donor interaction, surgical procedures, immunosuppression, and outcomes of patients included in the Spanish heart transplant registry from 2014 to 2023. Changes in survival were analyzed using the Kaplan-Meier method.

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Introduction And Objectives: The multiparametric implantable cardioverter-defibrillator HeartLogic index has proven to be a sensitive and timely predictor of impending heart failure (HF) decompensation. We evaluated the impact of a standardized follow-up protocol implemented by nursing staff and based on remote management of alerts.

Methods: The algorithm was activated in HF patients at 19 Spanish centers.

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  • * Patients with COPD showing signs of CVD or vice versa should be referred to the appropriate specialist, especially if they exhibit specific symptoms like palpitations or excessive dyspnea.
  • * Treatment for patients with both conditions may include specific medications, such as long-acting bronchodilators for COPD and cardioselective beta-blockers for CVD, tailored to the severity and frequency of exacerbations.
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  • Heart transplant recipients (HTr) are at greater risk for severe COVID-19, and a study analyzed their prognosis over the pandemic from February 2020 to October 2022.* -
  • Among 308 HTr studied, 39.2% were infected; those with pneumonia had significantly worse outcomes, with higher hospitalization and death rates compared to less severe cases.* -
  • Improvements in prognosis were noted over time, with reduced pneumonia (from 62% to 19%) and mortality (from 23% to 4%), attributed to factors like vaccination and early remdesivir treatment.*
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Heart transplant (HT) remains the best therapeutic option for patients with advanced heart failure (HF). The allocation criteria aim to guarantee equitable access to HT and prioritize patients with a worse clinical status. To review the HT allocation criteria, the Heart Failure Association of the Spanish Society of Cardiology (HFA-SEC), the Spanish Society of Cardiovascular and Endovascular Surgery (SECCE) and the National Transplant Organization (ONT), organized a consensus conference involving adult and pediatric cardiologists, adult and pediatric cardiac surgeons, transplant coordinators from all over Spain, and physicians and nurses from the ONT.

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  • The Spanish heart transplant registry provides annual updates, with the latest focusing on data from 2022 regarding clinical characteristics and survival outcomes of heart transplants.
  • In 2022, there were 311 heart transplants, marking a 3.0% increase from 2021, while demographic and clinical characteristics remained consistent with previous years.
  • Over the past decade, survival rates have stabilized at 1 year (81.4%) and 3 years (73.4%), with a noted decrease in urgent transplants and the use of circulatory support devices.
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Introduction And Objectives: Repetitive ambulatory doses of levosimendan are an option as a bridge to heart transplantation (HT), but evidence regarding the safety and efficacy of this treatment is scarce. The objective of the LEVO-T Registry is to describe the profile of patients on the HT list receiving levosimendan, prescription patterns, and clinical outcomes compared with patients not on levosimendan.

Methods: We retrospectively reviewed all patients listed for elective HT from 2015 to 2020 from 14 centers in Spain.

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Introduction And Objectives: Hypertension is highly common in heart failure (HF). However, there is limited information on its prevalence, circadian variation, and relationship with the various HF phenotypes. The objective of this study was to describe the prevalence of hypertension and its patterns in HF.

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Introduction And Objectives: This report updates the annual data of the Spanish Heart Transplant Registry with the procedures performed in 2021.

Methods: We describe the clinical profile, therapeutic characteristics and outcomes in terms of survival of the procedures performed in 2021. Their temporal trends are updated for the 2012 to 2020 period.

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Introduction And Objectives: The Index for Mortality Prediction After Cardiac Transplantation (IMPACT) score was derived and validated as a predictor of mortality after heart transplantation (HT). The primary objective of this work is to externally validate the IMPACT score in a contemporary Spanish cohort.

Methods: Spanish Heart Transplant Registry data were used to identify adult (>16 years) HT patients between January 2000 and December 2015.

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Background: The surgical approach for the treatment of a left ventricular assist device with severe infection may be controversial.

Material & Methods: We present the case of a patient implanted with a HeartWare™ HVAD as a bridge to transplant and chronic infection of the device by Pseudomonas who underwent a conservative partial treatment of the driveline tunnel and subsequently a heart transplantation and device removal were done.

Conclusions: The two-step simplified approach allowed the patient to be transplanted in a short period of time, with the abdominal wall healed and almost two-thirds of the driveline subcutaneous tunnel sterilized.

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Article Synopsis
  • - Telemonitoring using cardiac devices, like the HeartLogic algorithm from Boston Scientific, can enhance follow-up care for heart failure patients by tracking various health metrics, such as heart rate and physical activity.
  • - The HeartLogic algorithm monitors factors such as nocturnal heart rate and thoracic impedance to predict serious health events, showing high sensitivity in detecting heart failure issues.
  • - Despite promising detection abilities, the impact of HeartLogic on hospitalizations and mortality rates has not yet been confirmed in clinical trials, prompting a review of its functionality and real-world application.
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  • Hyperkalaemia is a significant issue for heart failure patients with reduced ejection fraction (HFrEF), impacting both the use of key medications and patient prognosis.
  • A study of 565 outpatients revealed that hyperkalaemia affected the ability to prescribe or maintain optimal doses of mineralocorticoid receptor antagonists (MRAs) in about 34.8% of cases.
  • Overall, the presence of hyperkalaemia is common among HFrEF patients and poses challenges in achieving effective medical treatment.
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Introduction And Objectives: HeartLogic is a multiparametric algorithm incorporated into implantable cardioverter-defibrillators (ICD). The associated alerts predict impending heart failure (HF) decompensations. Our objective was to analyze the association between alerts and clinical events and to describe the implementation of a protocol for remote management in a multicenter registry.

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Introduction And Objectives: The present report updates the main characteristics and outcomes of heart transplants in Spain to 2020.

Methods: We describe the main features of recipients, donors, surgical procedure, and immunosuppression in 2020. We also analyze the temporal trends of these characteristics and outcomes (survival) for the period 2011 to 2019.

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Despite the important changes in the management of heart transplantation in the recent decades, the use of endomyocardial biopsy is still necessary for the follow-up of these patients. However, this technique has several limitations, the most important being the substantial interobserver variability. In the last years multiple attempts have been made to find non-invasive assays for cardiac allograft surveillance, such as imaging modalities and serum biomarkers.

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  • The study investigates how truncating TTN variants (TTNtv) lead to dilated cardiomyopathy (DCM) by examining electrocardiograms (ECGs) and echocardiograms of TTNtv-DCM patients and their relatives.
  • Patients were categorized into five groups based on their left ventricular ejection fraction (LVEF), recovery status, and genetic factors, with analyses showing significant differences in T-index and abnormal T-wave prevalence among these groups.
  • The findings suggest that changes in repolarization patterns in ECGs can help identify patients with varying responses to treatment and highlight those at higher risk within the TTNtv-DCM spectrum.
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  • Intrapatient blood level variability (IPV) of calcineurin inhibitors has been linked to negative outcomes in solid organ transplants, but research in heart transplants is limited.
  • A study analyzed data from 1,581 heart transplant recipients to assess IPV's impact on rejection and mortality over a five-year period.
  • Findings suggest that while IPV showed a weak association with mid-term outcomes, patients on tacrolimus had better results and less variability compared to those on cyclosporine, particularly among recipients without early rejection episodes.
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Male patients are at increased risk for developing malignancy postheart transplantation (HT); however, real incidence and prognosis in both genders remain unknown. The aim of this study was to assess differences in incidence and mortality related to malignancy between genders in a large cohort of HT patients. Incidence and mortality rates were calculated for all tumors, skin cancers (SCs), lymphoma, and nonskin solid cancers (NSSCs) as well as survival since first diagnosis of neoplasia.

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This study aimed to evaluate the feasibility of a noninvasive operability assessment of chronic thromboembolic pulmonary hypertension (CTEPH) based on multidetector computed tomographic angiography (MCTA). Up to 176 patients were evaluated from January 2016 to April 2018. Throughout the first phase, the initial surgical decision was made based on MCTA with further analysis of pulmonary angiography (PA) in order to evaluate in which cases the initial decision was not modified by PA.

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