Publications by authors named "Delara Kamalizade"
Objective: Limbic encephalitis (LE) comprises a spectrum of inflammatory changes in affected brain structures including the presence of autoantibodies and lymphoid cells. However, the potential of distinct lymphocyte subsets alone to elicit key clinicopathological sequelae of LE potentially inducing temporal lobe epilepsy (TLE) with chronic spontaneous seizures and hippocampal sclerosis (HS) is unresolved.
Methods: Here, we scrutinized pathogenic consequences emerging from CD8 T cells targeting hippocampal neurons by recombinant adeno-associated virus-mediated expression of the model-autoantigen ovalbumin (OVA) in CA1 neurons of OT-I/RAG1 mice (termed "OVA-CD8 LE model").
Article Synopsis
- * Researchers utilized various techniques, including immunoblotting and mass spectrometry, to identify Drebrin as the target antigen in patients' sera, finding a strong correlation with seizure activity and other neurological symptoms.
- * The findings suggest that anti-Drebrin autoantibodies may contribute to a chronic neurological syndrome characterized by repeated seizures, memory issues, and brain inflammation, indicating potential targets for immunosuppressive therapies.