Publications by authors named "Delaney Raine Fritz"
The direct relationship between facilitative glucose transporters (GLUTs) and metabolic diseases opens new avenues for sensing metabolic deregulations and drives the development of molecular probes for GLUT-targeted detection of metabolic diseases. Radiotracer-based molecular imaging probes have been effectively utilized in reporting alterations in sugar uptake as an indication of metabolic deregulations, cancer development, or inflammation. Progress in developing fluorophore-based tools facilitated GLUT-specific analyses using more accessible fluorescence-based instrumentation.
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- Two new sensitive cyanine dyes, referred to as probes and , have been created for quick detection of NAD(P)H levels.
- These probes have low fluorescence without NAD(P)H but change significantly when it is present, absorbing and fluorescing at new wavelengths due to chemical modifications.
- The probes have been successfully used to monitor NAD(P)H in live cells, particularly in cancer studies and during glycolysis under hypoxic conditions.
We describe a simple but efficient approach to make fluorescent probes A and B based on rhodol dyes incorporated with salicyaldehyde moiety for monitoring pH changes in mitochondria under oxidative stresses and hypoxia conditions, and for tracking mitophagy processes. Probes A and B possess p values (p ≈ 6.41 and 6.
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