DNA Quantity and Quality Comparisons between Cryopreserved and FFPE Tumors from Matched Pan-Cancer Samples.

Personalized cancer care requires molecular characterization of neoplasms. While the research community accepts frozen tissues as the gold standard analyte for molecular assays, the source of tissue for testing in clinical cancer care comes almost universally from formalin-fixed, paraffin-embedded tissue (FFPE). As newer technologies emerge for DNA characterization that requires higher molecular weight DNA, it was necessary to compare the quality of DNA in terms of DNA length between FFPE and cryopreserved samples.

Engineering the kinetic stability of a β-trefoil protein by tuning its topological complexity.

Kinetic stability, defined as the rate of protein unfolding, is central to determining the functional lifetime of proteins, both in nature and in wide-ranging medical and biotechnological applications. Further, high kinetic stability is generally correlated with high resistance against chemical and thermal denaturation, as well as proteolytic degradation. Despite its significance, specific mechanisms governing kinetic stability remain largely unknown, and few studies address the rational design of kinetic stability.

Law enforcement officers' perception of rape and rape victims: a multimethod study.

In a study to assess law enforcement officers' perceptions of rape and rape victims, researchers asked 149 law enforcement officers to respond to surveys which included a definition of rape measure, an unfounded rape claims measure, and the Rape Myth Acceptance Scale-Revised (RMA-R) measure. Although most officers scored low on the RMA-R--indicating that they did not adhere to myths about rape--most officers also responded with incomplete definitions of rape and inaccurate estimates of the number of false rape claims. Multivariate analyses indicated that officers' open-ended responses did not predict their scores on the RMA-R scale.