Publications by authors named "Delanaye P"
Background: Blood pressure (BP) control in haemodialysis (HD) patients is essential. Peri-dialytic BP levels do not accurately diagnose hypertension or predict the cardiovascular (CV) mortality.
Methods: In this study, we recruited 43 adult patients who had been on chronic HD for ≥3 months.
The 2024 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for chronic kidney disease (CKD) evaluation and management bring important updates, particularly for European laboratories. These guidelines emphasize the need for harmonization in CKD testing, promoting the use of regional equations. In Europe, the European Kidney Function Consortium (EKFC) equation is particularly suited for European populations, particularly compared to the CKD-EPI 2021 race-free equation.
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- * The speed at which potassium levels increase is crucial because quicker changes can lead to severe and potentially life-threatening symptoms; thus, acute hyperkalemia requires immediate treatment.
- * Although there's no universal standard for measuring the severity of hyperkalemia, electrocardiogram (ECG) changes are important indicators; this article discusses current knowledge and suggests a management approach for acute cases.
Article Synopsis
- The study evaluates the effectiveness of machine learning (ML) techniques in predicting glomerular filtration rate (GFR) compared to the traditional EKFC equation, which measures kidney function.
- Using data from 19,629 patients across 13 cohorts, the researchers tested various ML methods, particularly focusing on factors like age, sex, and serum creatinine levels.
- Results indicated that the random forest (RF) method performed similarly to EKFC, with slight advantages for RF in younger patients, suggesting ML could enhance future GFR prediction methods.
Background: The use of interstitial glucose monitoring devices such as flash glucose monitoring has been shown to be beneficial in patients with type 1 diabetes mellitus (T1DM). However, these devices have been little studied in patients with diabetes treated by chronic haemodialysis (HD).
Methods: The goal of this prospective, observational, multicentric study was to evaluate the analytical performance of the FreeStyle Libre 2 (FSL2) sensor in T1DM patients during HD sessions.
Article Synopsis
- * The SUSTAIN-6 study (2016) highlighted semaglutide's safety and cardiovascular benefits, leading to further trials confirming its effectiveness in patients with diabetes, chronic kidney disease, and heart failure.
- * Higher doses (2.4 mg/week) in obesity studies confirmed semaglutide's potential for improving health outcomes in individuals at high risk for cardiovascular and kidney diseases.
Background: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this is debated.
View Article and Find Full Text PDFInternational consensus supports the development of standardized protocols for measured glomerular filtration rate (mGFR) to facilitate the integration of mGFR testing in both clinical and research settings. To this end, the European Kidney Function Consortium convened an international group of experts with relevant experience in mGFR. The working group performed an extensive literature search to inform the development of recommendations for mGFR determination using 1-compartment plasma clearance models and iohexol as the exogenous filtration marker.
View Article and Find Full Text PDFBackground And Hypothesis: The estimation of glomerular filtration rate (GFR) is one main tool to detect renal disease. The most used biomarker remains serum creatinine and the European Kidney Function Consortium (EKFCcrea) equation is the most validated in Europe. More recently, cystatin C, has been proposed.
View Article and Find Full Text PDFBackground: Children with overweight and obesity are at risk for developing chronic kidney disease (CKD). During lifestyle adjustment, the first step in the treatment of childhood obesity, body proportions are likely to change. The aim of this study was to examine how lifestyle intervention affects creatinine-based kidney function estimation in children with overweight and obesity.
View Article and Find Full Text PDFWhich is the best glomerular filtration marker: Creatinine, cystatin C or both?
Eur J Clin Invest
October 2024
Background: The glomerular filtration rate (GFR) is estimated by the serum or plasma concentration of creatinine and/or cystatin C using equations that include demographic data. The equations worldwide most widely used are those of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) consortium and updated in 2021 to remove the Afro-American racial correction factor. In 2021 and then in 2023, the European Kidney Function Consortium also developed equations based on creatinine and cystatin C, usable across the full age spectrum, and constructed by including the Q value (i.
View Article and Find Full Text PDFBackground: The Schwartz equation is the most widely used serum creatinine (SCr)-based formula to estimate the glomerular filtration rate (GFR) in children of European descent, but whether this applies to African children is unclear.
Methods: In a cross-sectional study, 513 apparently healthy African children aged 6 to 16 years were randomly recruited in school area of Kinshasa, the Democratic Republic of Congo (DRC). SCr was measured using calibrated enzymatic method.
Background: The inactive dephosphorylated and uncarboxylated form of the matrix Gla protein (dp-ucMGP) has been shown to be increased in plasma of inflammatory bowel disease (IBD) patients. Our aim was to assess if the plasmatic level of dp-ucMGP could reflect disease endoscopic activity, presence of strictures and cumulative structural bowel damage in Crohn's disease (CD) patients.
Methods: The plasmatic level of dp-ucMGP was measured in a monocentric cohort of prospectively recruited patients.
Background: In daily practice, glomerular filtration rate (GFR) is estimated with equations including renal biomarkers. Among these biomarkers, serum creatinine remains the most used. However, there are many limitations with serum creatinine, which we will discuss in the current review.
View Article and Find Full Text PDFEstimating glomerular filtration rate (GFR) is important in daily practice to assess kidney function and adapting the best clinical care of patients with and without chronic kidney disease. The new creatinine-based European Kidney Function Consortium (EKFC) equation is used to estimate GFR. This equation was developed and validated mainly in European individuals and based on a rescaled creatinine, with the rescaling factor (Q-value) defined as the median normal value of serum creatinine in a given population.
View Article and Find Full Text PDFFinerenone, a new nonsteroidal mineralocorticoid receptor antagonist, showed a significant reduction in a primary composite renal outcome in FIDELIO-DKD and a significant reduction in a primary composite cardiovascular outcome in FIGARO-DKD in patients with type 2 diabetes (T2D) and a chronic kidney disease (CKD). In a subsequent analysis that combined these two clinical trials (FIDELITY), the reduction becomes statistically significant when compared to placebo for both outcomes, with a hazard ratio of 0.86 (95 % confidence interval 0.
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- Creatinine-based eGFR is not very accurate for individuals due to factors like muscle mass affecting serum creatinine levels, while cystatin C provides a more consistent measure but doesn’t outperform creatinine alone.
- A new CKD-EPI equation has shown some bias based on race and performs poorly in Europe, while the EKFC equation offers better accuracy across age groups and populations, including non-white Europeans.
- There is a push for improvements in GFR estimation methods, like standardizing cystatin C assays, integrating muscle mass data, and exploring new biomarkers, alongside addressing discrepancies between cystatin C and creatinine to enhance patient outcomes.
Article Synopsis
- * Researchers tested a new calibration method using a reliable LC-MS/MS reference to standardize five different PTH immunoassays, aimed at reducing variability in test results.
- * The successful recalibration allows for harmonized PTH measurements across various tests, promoting clearer interpretation and better clinical decisions for patient care.