Tumor necrosis factor α -308 G>A polymorphisms and cervical cancer risk: a meta-analysis.

Objective: Tumor necrosis factor α (TNF-α), secreted mainly by activated macrophages, is recently involved in fighting against tumorigenesis. Tumor necrosis factor α -308 G>A, the common polymorphism in the promoter of TNF-α, has been implicated to alter the risk of cervical cancer, yet the results of relative studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed a meta-analysis based on 8 studies.

Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population.

Objective: MicroRNAs are tiny non-coding RNAs that reportedly play an important role in numerous physiological processes. A G>C polymorphism (rs2910164) is located on the passenger strand of the precursor of miR-146a, which could alter mature miR-146a expression. We hypothesized that a possible association exists between miR-146a gene polymorphisms and cervical cancer risk in a population-based control study of female residents in Jiangsu Province.

CCND1 G870A polymorphism and cervical cancer risk: a case-control study and meta-analysis.

Purpose: Cyclin D1 (CCND1) is a key regulatory protein in the G1/S checkpoint of the cell cycle. We hypothesized that the G870A polymorphism of CCND1 is associated with the risk for cervical cancer and performed a meta-analysis of eligible studies to evaluate this relationship.

Methods: In a case-control study of 300 patients with newly diagnosed cervical cancer and 312 cancer-free controls who were frequency-matched by age, we genotyped the G870A polymorphism of CCND1 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

[Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphisms of MTHFR C677T and A1298C].

Objective: To explore the relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphism of MTHFR C677T and A1298C in Chinese population.

Methods: Case-control study design was employed. MTHFR genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism techniques (PCR-RFLP).