Publications by authors named "Delal Dalga"
Key Points: Glomerular proteinuria induces large-scale changes in gene expression along the nephron. Increased protein uptake in the proximal tubule results in axial remodeling and injury. Increased protein delivery to the distal tubule causes dedifferentiation of the epithelium.
View Article and Find Full Text PDFChronic kidney disease (CKD) is a global health issue with increasing prevalence. Despite large improvements in current therapies, slowing CKD progression remains a challenge. A better understanding of renal pathophysiology is needed to offer new therapeutic targets.
View Article and Find Full Text PDFPCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells.
Am J Physiol Renal Physiol
June 2023
Article Synopsis
- PCK1 (phosphoenolpyruvate carboxykinase 1) is a key enzyme in kidney cells that helps convert oxaloacetate to phosphoenolpyruvate and plays a role in maintaining metabolic processes such as gluconeogenesis and ammoniagenesis.
- Deleting PCK1 in kidney-specific knockout mice led to metabolic issues including hyperchloremic metabolic acidosis and altered metabolism, causing kidney injury and decreased ATP production.
- Enhancing PCK1 expression during chronic kidney disease improved renal function, highlighting its importance for acid-base balance, energy production, and overall tubular health.
Introduction: CKD is associated with alterations of tubular function. Renal gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting, but how and why CKD affects this process and the repercussions of such regulation are unknown.
Methods: We used data on the renal gluconeogenic pathway from more than 200 renal biopsies performed on CKD patients and from 43 kidney allograft patients, and studied three mouse models, of proteinuric CKD (POD-ATTAC), of ischemic CKD, and of unilateral urinary tract obstruction.