Risk factors for conversion to general anesthesia for urgent cesarean among women with labor epidural analgesia: A retrospective case-control study.

Objectives: General anesthesia for cesarean is associated with an increased risk of maternal morbidity compared with neuraxial anesthesia. Reducing the rate of general anesthesia for urgent cesarean in women with epidural analgesia may improve maternal outcomes. Our objective was to identify the rate and factors associated with the conversion to general anesthesia for urgent cesarean among women with labor epidural analgesia.

Factors associated with treatment satisfaction in patients with hidradenitis suppurativa: results from the Global VOICE project.

Background: Nearly half of patients with hidradenitis suppurativa (HS) report dissatisfaction with their treatment. However, factors related to treatment satisfaction have not been explored.

Objectives: To measure associations between treatment satisfaction and clinical and treatment-related characteristics among patients with HS.

A Simple Approach for Gas Blender on Extracorporeal Membrane Oxygenation in Resource Shortage Context.

With the massive influx of patients during COVID-19 pandemic into intensive care unit, resources have quickly been stretched to the limit, including extracorporeal membrane oxygenation (ECMO). Gas blender attached to ECMO is used to allow precise adjustment of characteristics of fresh gas flow, that is, blood oxygen delivery and carbon dioxide removal. To cope with the gas blender shortage, we describe a back-up system set up in our French tertiary referral ECMO center using air and oxygen flowmeters.

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa.

Hidradenitis suppurativa (HS) is a chronic skin disorder of unknown etiology that manifests as recurrent, painful lesions. Cutaneous dysbiosis and unresolved inflammation are hallmarks of active HS, but their origin and interplay remain unclear. Our metabolomic profiling of HS skin revealed an abnormal induction of the kynurenine pathway of tryptophan catabolism in dermal fibroblasts, correlating with the release of kynurenine pathway-inducing cytokines by inflammatory cell infiltrates.

The Surface Microbiome of Clinically Unaffected Skinfolds in Hidradenitis Suppurativa: A Cross-Sectional Culture-Based and 16S rRNA Gene Amplicon Sequencing Study in 60 Patients.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin associated with specific lesional dysbiotic features. We studied the microbiome of clinically unaffected typical HS sites (armpits, inguinal folds, and gluteal clefts) in 60 patients with HS and 17 healthy controls. A total of 192 samples obtained by swabbing were analyzed by bacterial cultures.

Rifampin-moxifloxacin-metronidazole combination therapy for severe Hurley stage 1 hidradenitis suppurativa: prospective short-term trial and 1-year follow-up in 28 consecutive patients.

Background: Severe Hurley stage 1 hidradenitis suppurativa (HS1) is a difficult-to-treat form of the disease.

Objective: To assess the efficacy and tolerance of the oral combination of rifampin (10 mg/kg once daily)/moxifloxacin (400 mg once daily)/metronidazole (250-500 mg 3 times daily) (RMoM) treatment strategy in patients with severe HS1.

Methods: Prospective, open-label, noncomparative cohort study in 28 consecutive patients.

Evaluating patients' unmet needs in hidradenitis suppurativa: Results from the Global Survey Of Impact and Healthcare Needs (VOICE) Project.

Background: A needs assessment for patients with hidradenitis suppurativa (HS) will support advancements in multidisciplinary care, treatment, research, advocacy, and philanthropy.

Objective: To evaluate unmet needs from the perspective of HS patients.

Methods: Prospective multinational survey of patients between October 2017 and July 2018.

Investigation of the quinine sulfate dihydrate spectral properties and its effects on Cherenkov dosimetry.

Recent studies have proposed that adding quinine to water while performing Cherenkov volumetric dosimetry improves the skewed percent depth dose measurement. The aim of this study was to quantify the ability of quinine to convert directional Cherenkov emission to isotropic fluorescence and evaluate its contribution to the total emitted light. Aqueous solutions of quinine were prepared with distilled water at various concentrations (0.

Dosimetric properties of colloidal quantum dot-based systems for scintillation dosimetry.

Colloidal quantum dots (cQDs) are starting to be used in radiation detection, either combined with an organic fluorophore or used as a sole luminescent material. In the latter case, only few studies report on cQD-based detectors for medical applications, especially for scintillation dosimetry in radiation therapy. Moreover, most of these studies focus on the effects of radiation on cQD photoluminescence but do not look into the properties of the scintillation signal itself.

Performance and Suitability of Mindray BS480©: A Fully Open Clinical Chemistry Analyzer.

Background: Mindray BS480©, a multi-parametric and random-access clinical chemistry instrument, is suitable for medium-sized hospital applications. Large laboratories in hospital environments require high throughput non-emergency settings that could slow routine production lines. In addition, the possibility to adapt to different methodologies is of great convenience for improving the transfer from manual to automated applications.

Characterization of a binary system composed of luminescent quantum dots for liquid scintillation.

Scintillation dosimetry has evolved towards utilizing 3D liquid dosimeters to perform quality assurance verification of complex treatment configuration for photon, electron and proton beams. However, most of the fluorophores utilized in these dosimeters are alike and present limitations. This study aims to establish the profile of CdSe colloidal quantum dots (cQDs) that were given the role of the fluorophore in a binary liquid scintillation system.

Evaluation of the mobility of the shoulder and quality of life after perforator flaps for recalcitrant axillary hidradenitis.

Background: Hidradenitis suppurativa is a very debilitating disease, treated by antibiotics and excision. The reconstruction is usually done by secondary wound healing and/or split-thichness skin graft. The aim of this study was to evaluate the reconstruction of the axilla with local perforator flaps as a single stage surgical treatment.

[Clinical application of attachment].

By favouring the proximity of a caregiver, attachment is essential for enabling children to live and grow. It constitutes both an emotion regulator and an internal security base. It is a complex process which evolves throughout a person's lifetime.

Impact of Expert Pathologic Review of Lymphoma Diagnosis: Study of Patients From the French Lymphopath Network.

Purpose To prospectively assess the clinical impact of expert review of lymphoma diagnosis in France. Materials and Methods From January 2010 to December 2013, 42,145 samples from patients with newly diagnosed or suspected lymphomas were reviewed, according to the 2008 WHO classification, in real time by experts through the Lymphopath Network. Changes in diagnosis between referral and expert review were classified as major or minor according to their potential impact on patient care.

The Microbiological Landscape of Anaerobic Infections in Hidradenitis Suppurativa: A Prospective Metagenomic Study.

Background: Hidradenitis suppurativa (HS) is a frequent and severe disease of the skin, characterized by recurrent or chronic skinfold suppurative lesions with a high impact on quality of life. Although considered inflammatory, antimicrobial treatments can improve or lead to clinical remission of HS, suggesting triggering microbial factors. Indeed, mixed anaerobic microbiota are associated with a majority of HS lesions.

Characterization and identification of eight designer benzodiazepine metabolites by incubation with human liver microsomes and analysis by a triple quadrupole mass spectrometer.

Designer benzodiazepines (DBZDs) have become of particular importance in the past few years. The metabolite monitoring of DBZD in biological fluids could be of great interest in clinical and forensic toxicology. However, DBZD metabolites are not known or not commercially available.