Publications by authors named "Dekui Jin"

Introduction: The oxidative balance score (OBS) is a holistic measure that represents the overall equilibrium between prooxidants and antioxidants in one's diet and lifestyle. Little research has been conducted on the correlation between OBS and 10-year atherosclerotic cardiovascular disease risk (ASCVD). Therefore, the objective of this investigation was to examine the potential correlation between OBS and 10-year risk.

View Article and Find Full Text PDF

Non-natural building blocks (BBs) present a vast reservoir of chemical diversity for molecular recognition and drug discovery. However, leveraging evolutionary principles to efficiently generate bioactive molecules with a larger number of diverse BBs poses challenges within current laboratory evolution systems. Here, we introduce programmable chemical evolution (PCEvo) by integrating chemoinformatic classification and high-throughput array synthesis/screening.

View Article and Find Full Text PDF
Article Synopsis
  • - The study explores the connection between inflammation-related gut bacteria, specifically Solobacterium moorei (S. moorei), and the progression of adenomatous polyps (APs), which are linked to colorectal cancer risk.
  • - Researchers found that S. moorei was enriched in polyps and correlated with increased inflammation markers in patients, contributing to the growth of cancerous cells and promoting intestinal dysplasia in mouse models.
  • - Targeting S. moorei might be a new approach to prevent the worsening of APs by reducing inflammation and maintaining the integrity of the intestinal barrier.
View Article and Find Full Text PDF

Background: To assess the association between 12 food groups intake and the risk of urologic cancers.

Methods: We scanned PubMed and Web of Science databases up to April 1st, 2023, and 73 publications met the inclusion criteria in the meta-analysis. We used a random effects model to estimate the summary risk ratios (RRs) and 95% confidence intervals (95% CI).

View Article and Find Full Text PDF

Copper is an essential micronutrient for human body and plays a vital role in various biological processes including cellular respiration and free radical detoxification. Generally, copper metabolism in the body is in a stable state, and there are specific mechanisms to regulate copper metabolism and maintain copper homeostasis. Dysregulation of copper metabolism may have a great connection with various types of diseases, such as Wilson disease causing copper overload and Menkes disease causing copper deficiency.

View Article and Find Full Text PDF

Doxorubicin (DOXO) is a potent chemotherapeutic drug widely used to treat various cancers. However, its clinical application is limited due to serious adverse effects on dose-dependent cardiotoxicity. Although the underlying mechanism has not been fully clarified, DOXO-induced cardiotoxicity has been mainly attributed to the accumulation of reactive oxygen species (ROS) in cardiomyocytes.

View Article and Find Full Text PDF

Doxorubicin (DOXO) can be used to treat a variety of human tumors, but its clinical application is limited due to severe cardiotoxic side effect. Here, we explore the role of -glucan in DOXO-induced cardiotoxicity in mice and study its underlying mechanism. When co-administered with DOXO, -glucan was observed to prevent left ventricular dilation and fibrosis.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined the impact of thin-cap fibroatheromas (TCFAs) on the neointimal coverage of stents in patients with acute coronary syndrome after 9 months of implantation, using optical coherence tomography (OCT).
  • Researchers enrolled 93 patients, separating them into a TCFA group (47 patients) and a non-TCFA group (46 patients) to compare results on neointimal coverage, incidence of uncoverage, and stent malapposition.
  • Findings revealed that the TCFA group had smaller lumen diameters, greater stenosis, and significantly lower mean intimal thickness compared to the non-TCFA group, indicating that TCFAs are predictors of incomplete neointimal coverage and contribute to
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session0jb861bk6oot7q224cjam5ivqsgjo1ui): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once