Publications by authors named "Dekai Wang"

Article Synopsis
  • The study examined how ferroptosis, a form of cell death, relates to the miR-223-3p/ITPR3 pathway in diabetic kidney disease (DKD).
  • Diabetic patients had higher levels of iron ions, calcium ions, and lipid peroxidation, with high glucose reducing miR-223-3p, which in turn impacted ferroptosis regulators.
  • Overexpressing miR-223-3p counteracted the adverse effects of high glucose on these markers and ITPR3, suggesting that targeting this pathway might offer new treatment options for DKD.
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  • The auxin response factor (ARF) is crucial for regulating plant growth and stress response by binding to auxin response gene promoters; however, specific roles in Fagopyrum dibotrys remain unclear.
  • A study identified 26 FdARF genes, analyzing their chromosomal distribution, gene structures, and protein properties, revealing a predominant presence on chromosome 4 and varying subcellular localizations.
  • Expression profiling showed these genes are predominantly active in different plant tissues and respond differentially to abiotic stress, suggesting FdARFs play a significant role in the plant's stress response.
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Unlabelled: Auxin response factors (ARFs), as the main components of auxin signaling, play a crucial role in various processes of plant growth and development, as well as in stress response. So far, there have been no reports on the genome-wide identification of the ARF transcription factor family in , a deciduous tree plant in the family Juglaceae. In this study, a total of 34 genes were identified based on whole genome sequence, and they were unevenly distributed on 16 chromosomes, with the highest distribution on chromosome 6.

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Hybrid rice has achieved high grain yield and greatly contributes to food security, but the manual-labour-intensive hybrid seed production process limits fully mechanized hybrid rice breeding. For next-generation hybrid seed production, the use of small-grain male sterile lines to mechanically separate small hybrid seeds from mixed harvest is promising. However, it is difficult to find ideal grain-size genes for breeding ideal small-grain male sterile lines without penalties in the number of hybrid seeds and hybrid rice yield.

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Introduction: With the increasing demand for health products derived from Polygonati rhizoma (PR), people begin to artificially plant Hua () in the middle and lower reaches of the Yangtze River. To promote cultivation and increase farmers' income, efforts are needed to understand the ways to obtain high-quality PR under artificial cultivation conditions.

Methods: Rhizomes of artificial planting and rhizosphere soils were collected across five regions in Zhejiang Province, China.

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  • This study evaluates the safety and effectiveness of SGLT2 inhibitors for treating type 1 diabetes by reviewing randomized controlled trials (RCTs) through a thorough literature search up to September 2022.! -
  • It included 16 RCTs with a total of 7,192 patients, showing that SGLT2 inhibitors significantly lower key diabetes indicators such as HbA1c and fasting plasma glucose, while also reducing body weight and insulin dosage.! -
  • The findings suggest that SGLT2 inhibitors do not increase the risk of hypoglycemia, urinary tract infections, or diarrhea, indicating they might be a safe option for managing type 1 diabetes.
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Ethnopharmacological Relevance: Coix lacryma-jobi var. ma-yuen (Romanet du Caillaud) Stapf is a plant of the genus Coix in the Gramineae family. Coix seed is cultivated in various regions throughout China.

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Huperzia crispata is a traditional Chinese herb plant and has attracted special attention in recent years for its products Hup A can serve as an acetylcholinesterase inhibitor (AChEI). Although the chloroplast (cp) genome of H. crispata has been studied, there are no reports regarding the Huperzia mitochondrial (mt) genome since the previously reported H.

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  • The study identifies and characterizes 32 ClHSP20 genes in Coix, focusing on their role in plant responses to heat and drought stress.
  • Phylogenetic and duplication analyses reveal that these genes belong to 11 subfamilies and have expanded mainly through tandem and segment duplication events.
  • Expression profiles indicate that many ClHSP20 genes are regulated by heat and drought, suggesting their significance in plant growth and stress response mechanisms.
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Golden buckwheat (, also known as ) is a traditional edible herbal medicinal plant with a large number of secondary metabolites and is considered to be a source of therapeutic compounds. Different ecological environments have a significant impact on their compound content and medicinal effects. However, little is known about the interactions between soil physicochemical properties, the rhizosphere, endophytic fungal communities, and secondary metabolites in .

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Article Synopsis
  • Auxin response factor (ARF) is a key transcription factor in plants that regulates genes related to growth, development, and stress responses; this study focused on the ARF gene family in Coix lacryma-jobi L., a plant with medicinal and nutritional value.
  • Researchers identified 27 ClARF genes in the Coix genome, which are distributed unevenly across 8 chromosomes, and most of these genes were predicted to function in the nucleus, with some linked to stress response.
  • The study also found that gene duplication and purifying selection influenced the evolution of the ClARF gene family, while expression analysis showed their varying responses to hormones and abiotic stress across different plant tissues.
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The saponins of had many pharmacological activities such as antitumor, antioxidation, and blood sugar lowering, which were synthesized by two pathways: mevalonate (MVA) and methylerythritol phosphate (MEP). 3-Hydroxy-3-methylglutaryl coenzyme A synthase (HMGS) was the key enzyme in the MVA synthesis pathway, and its expression level may affect the accumulation of saponins which were the main active ingredients of . In this study, we successfully cloned and from and their sequence similarity was 93.

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Background: Huperzia crispata, belonging to the Huperziaceae family, is one of the most essential resources of huperzine A for candidate drugs to treat Alzheimer's diseases. However, there is very limited information about H. crispat, and its taxonomic status and interspecific relationships between Huperzia species are still unclear.

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Background: Huperzine A (Hup A) has attracted considerable attention as an effective therapeutic candidate drug used to treat Alzheimer's disease. Whereas, the production of Hup A from wild plants faced a major challenge, which is the wild Huperzia Serrata harbor a low Hup A content, has a long-life cycle, and has a small yield. At present, several reports showed that Hup A is produced by various endophytic fungal strains isolated from H.

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  • Polygonati rhizoma (PR) is a traditional medicinal and edible product known for its health benefits, primarily due to its rich content of active neutral polysaccharides that exhibit antioxidant and hypoglycemic properties.
  • Four types of neutral polysaccharides from different regions of China were isolated and analyzed, revealing variations in their monosaccharide composition, molecular weights, and structural features, including the presence of α- and β-glycosidic bonds.
  • The study found that the biological activities of these polysaccharides are closely linked to their chemical structure and composition, indicating that their health benefits are influenced by their specific molecular characteristics.
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As a traditional Chinese herb, the rhizomes of Polygonatum sibiricum Red. are rich in various compounds which have plenty of pharmacological applications and biological activities. Among them, Polygonatum sibiricum polysaccharides (PSP) are the main active ingredients and exhibit a broad range of pharmacological.

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Regulation of seed size is a key strategy for improving crop yield and is also a basic biological question. However, the molecular mechanisms by which plants determine their seed size remain elusive. Here, we report that the GW2-WG1-OsbZIP47 regulatory module controls grain width and weight in rice.

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Panicle size and grain number are important agronomic traits and influence grain yield in rice (Oryza sativa), but the molecular and genetic mechanisms underlying panicle size and grain number control remain largely unknown in crops. Here we report that LARGE2 encodes a HECT-domain E3 ubiquitin ligase OsUPL2 and regulates panicle size and grain number in rice. The loss of function large2 mutants produce large panicles with increased grain number, wide grains and leaves, and thick culms.

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Regulation of grain size is crucial for improving crop yield and is also a basic aspect in developmental biology. However, the genetic and molecular mechanisms underlying grain size control in crops remain largely unknown despite their central importance. Here, we report that the MEI2-LIKE PROTEIN4 (OML4) encoded by the gene is phosphorylated by GLYCOGEN SYNTHASE KINASE2 (GSK2) and negatively controls grain size and weight in rice ().

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Salicylic acid (SA) is the major metabolite and active ingredient of aspirin; both compounds reduce pain, fever, and inflammation. Despite over a century of research, aspirin/SA's mechanism(s) of action is still only partially understood. Here we report the results of a genome-wide, high-throughput screen to identify potential SA-binding proteins (SABPs) in human HEK293 cells.

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The interplay between abscisic acid (ABA) and salicylic acid (SA) influences plant responses to various (a)biotic stresses; however, the underlying mechanism for this crosstalk is largely unknown. Here, we report that type 2C protein phosphatases (PP2Cs), some of which are negative regulators of ABA signaling, bind SA. SA binding suppressed the ABA-enhanced interaction between these PP2Cs and various ABA receptors belonging to the PYR/PYL/RCAR protein family.

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Grain size and shape are two crucial traits that influence grain yield and grain appearance in rice. Although several factors that affect grain size have been described in rice, the molecular mechanisms underlying the determination of grain size and shape are still elusive. In this study we report that WIDE AND THICK GRAIN 1 (WTG1) functions as an important factor determining grain size and shape in rice.

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Functional chloroplast generation depends on the precise coordination of gene expression between the plastid and the nucleus and is essential for plant growth and development. In this study, a rice (Oryza sativa) mutant that exhibited albino and seedling-lethal phenotypes was isolated from aCo-irradiated rice population. The mutant gene was identified as an ortholog of the Arabidopsis plastid transcriptionally active chromosome protein 2 (pTAC2) gene, and the mutant strain was designated osptac2.

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OsANN1 is a member of the annexin protein family in rice. The function of this protein and the mechanisms of its involvement in stress responses and stress tolerance are largely unknown. Here it is reported that OsANN1 confers abiotic stress tolerance by modulating antioxidant accumulation under abiotic stress.

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Article Synopsis
  • - Serine hydroxymethyltransferase (SHMT) plays a crucial role in one carbon metabolism and photorespiration, impacting plant growth, development, and stress resistance.
  • - The rice gene OsSHM1, linked to Arabidopsis SHM1, was identified, and the osshm1 mutant displayed severe chlorotic lesions and stunted growth at normal CO2 levels, but thrived under elevated CO2, indicating a typical photorespiratory response.
  • - OsSHM1 is expressed in various plant organs, mainly in leaves, and is located in the mitochondria, revealing its conserved molecular function across rice and Arabidopsis species.
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