Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways.

Prenatal exposure to metals has been associated with impaired neurodevelopment in children, but the detailed molecular mechanisms remain largely unknown. Based on the Wuhan Healthy Baby Cohort, China (N = 1088), eleven metals were measured in maternal urine during early pregnancy (13.1 ± 1.

Newborn metabolomic signatures of maternal vanadium exposure and reduced birth size.

Prenatal exposure to vanadium has been associated with reduced birth size, however, the specific molecular mechanism underlying this effect remains largely unexplored. We measured vanadium in maternal plasma during early pregnancy, and characterized metabolomics profiling in cord blood among 1020 mother-infant pairs from the Wuhan Healthy Baby Cohort, China. After adjusting for potential confounders, a 2-fold increase in maternal plasma vanadium concentration was associated with a decrease of 25.

Facile Preparation of Stereoblock PLA From Ring-Opening Polymerization of -Lactide by a Synergetic Binary Catalytic System Containing Ureas and Alkoxides.

Ring-opening polymerization (ROP) of cyclic esters/lactones by efficient catalysts is a powerful method for synthesis of biodegradable and biocompatible polyesters with well-defined structures. To develop catalytic systems that are fast, selective and controlled is a persistent effort of chemists. In this contribution, we report a binary urea/alkoxide catalytic system that could catalyze ROP of -LA in a fast (over 90% conversion within 1-2 min), stereoselective ( up to 0.

Chromium complexes supported by the bidentate PN ligands: synthesis, characterization and application for ethylene polymerization.

Chromium-based complexes are among the most important catalysts in the field of ethylene polymerization and oligomerization. Heterogeneous Cr Phillips catalysts account for more than one-third of the commercialized high density polyethylene (HDPE). In this contribution, chromium complexes, LCrCl3 (Cr1-Cr4: L = 2,6-R1-4-R2-C6H2-N[double bond, length as m-dash]CH-C6H4-2-PPh2; Cr1: R1 = H, R2 = H; Cr2: R1 = Me, R2 = H; Cr3: R1 = iPr, R2 = H; Cr4: R1 = Ph2CH, R2 = iPr), have been synthesized and characterized by elemental analysis, ESI and IR spectroscopy.

[Analysis of urine screening results for school-age children in Zhucheng City of Shandong Province of China in 2013].

Objective: To study the significance of urine screening for school-age children by analyzing urine screening results of school-age children from Zhucheng City, Shandong Province, China, in 2013.

Methods: A total of 37 344 school-age children were randomly selected from children 6 to 12 years of age in Zhucheng City. Morning urine was tested by routine screening test, and the children who tested positive were re-tested after two weeks.