Gentirigeoside B from Franch Prolongs Yeast Lifespan via Inhibition of TORC1/Sch9/Rim15/Msn Signaling Pathway and Modification of Oxidative Stress and Autophagy.

Gentirigeoside B (GTS B) is a dammaren-type triterpenoid glycoside isolated from Franch, a traditional Chinese medicinal plant. In the present study, the evaluation of the anti-aging effect and action mechanism analysis for this compound were conducted. GTS B significantly extended the replicative lifespan and chronological lifespan of yeast at doses of 1, 3 and 10 μM.

A New Geniposidic Acid Derivative Exerts Antiaging Effects through Antioxidative Stress and Autophagy Induction.

Two compounds that can prolong the replicative lifespan of yeast, geniposidic acid (Compound ) and geniposide (Compound ), were isolated from Ellis. Compared with Compound , Compound was different at C11 and showed better bioactivity. On this basis, seven new geniposidic derivatives (-) were synthesized.

Amarogentin from Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress.

In the present study, the replicative lifespan assay of yeast was used to guide the isolation of antiaging substance from Franch, a traditional Chinese medicine. A compound with antiaging effect was isolated, and the chemical structure of this molecule as amarogentin was identified by spectral analysis and compared with the reported data. It significantly extended the replicative lifespan of K6001 yeast at doses of 1, 3, and 10 M.

Novel Anti-Aging Benzoquinone Derivatives from Wall.

The aim of this study was to investigate anti-aging molecules from Wall, a traditional medicinal plant used in the Unani and Ayurvedic systems of medicine. During bioassay-guided isolation, two known benzoquinones, allomicrophyllone () and ehretiquinone () along with three novel benzoquinones designated as ehretiquinones B-D (-) were isolated from . Their structures were characterized by spectroscopic analysis through 1D and 2D NMR, by MS spectroscopic analysis and comparing with those reported in the literatures.