Controlled Release of Molecular Intercalants from Two-Dimensional Nanosheet Films.

Solution co-deposition of two-dimensional (2D) nanosheets with chemical solutes yields nanosheet-molecular heterostructures. A feature of these macroscopic layered hybrids is their ability to release the intercalated molecular agent to express chemical functionality on their surfaces or in their near surroundings. Systematic design methods are needed to control this molecular release to match the demand for rate and lifetime in specific applications.

Early life neuroimmune challenge protects the brain after sepsis in adult rats.

Evidences has suggested that in the early life the innate immune system presents plasticity and the time and dose-adequate stimuli in this phase may program long-lasting immunological responses that persist until adulthood. We aimed to evaluate whether LPS challenge in early childhood period may modulate brain alterations after sepsis in adult life. Experiments were performed to evaluate the LPS challenge in early childhood or adult period on acute and long-term brain alterations after model of sepsis by cecal ligation and perforation (CLP) in adult life.