Publications by authors named "Deisiany Gomes Ferreira"

Fungal infections caused by yeast have increased in recent decades, becoming a major threat to public health. Antifungal therapy represents a challenging problem because, in addition to presenting many side effects, fungal resistance has been increasing in recent years. As a result, the search for new therapeutic agents has advanced with the use of new technologies such as nanoparticles (NPs).

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Article Synopsis
  • - The study evaluated a new hybrid compound derived from oxadiazol-4-methoxynaphthalene for its potential to inhibit a specific virus and clinical isolates, alongside its interaction with anti-tuberculosis drugs.
  • - Researchers determined the minimal inhibitory concentration, conducted time kill curve assays, and assessed pharmacokinetics and cytotoxicity to understand the effectiveness and safety of the compound.
  • - The findings suggest that the newly synthesized molecule shows promising anti-viral activity with low toxicity, making it a candidate for further development as an anti-TB drug.
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Objective: To analyse the records of male hospitalisation for fungal infections, including their spatial distribution and the main invasive epidemiological and sociodemographic characteristics in the State of Paraná, Brazil.

Methods: Spatial analysis based on data from male admission records for invasive fungal infections (IFIs) in the State of Paraná, from 2015 to 2019. Data were taken from the hospital records obtained in the Hospital Information System of the Unified Health System, being collected, georeferenced and analysed to infer the existence of autocorrelation with the hospitalisation rates in the state.

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Human activity directly or indirectly causes climate change, promoting changes in the composition of the atmosphere. This change is beyond the variation of the natural climate. In this manner, climate change could create an environmental pressure which is enough to trigger new fungal diseases.

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