Publications by authors named "Deisi L Braga"
Cellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C.
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- Emerging research shows that RNA transport between cells is an important signaling mechanism in mammals and is also present in the nematode C. elegans via the systemic RNA interference (RNAi) pathway.
- Mutations in the SID-1 protein, which is crucial for RNA uptake, do not negatively impact C. elegans health, but overexpressing SID-1 in specific tissues leads to a shorter lifespan due to dysregulated RNA signaling.
- The study identifies the need for balanced systemic RNA signaling, coining the term Intercellular/Extracellular Systemic RNA imbalance (InExS) to describe how imbalances can significantly affect longevity in organisms.
As life expectancy increases worldwide, ageing and age-related diseases arise as a major issue for societies around the globe. Understanding the biological mechanisms underlying the ageing process is thus instrumental for the development of efficient interventions aimed to prevent and treat age-related conditions. Current knowledge in the biogerontology field points to epigenetics as a critical component of the ageing process, not only by serving as a bona-fide marker of biological age but also by controlling and conferring inheritability to cellular and organismal ageing.
View Article and Find Full Text PDFBreast Cancer (BC) encompasses numerous entities with different biological and behavioral characteristics, favored by tumor molecular complexity. (neem) presents phenolic compounds, indicating its potential as an antineoplastic compound. The present study aimed to evaluate the cellular response of MCF10, MCF7, and MDA-MB-231 breast cell lines to ethanolic extracts of neem leaves (EENL) obtained by dichloromethane (DCM) and ethyl acetate (EA) solvent.
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