Ascorbic acid improves impaired venous and arterial endothelium-dependent dilation in smokers.

Aim: To compare the acute effects of ascorbic acid on vasodilation of veins and arteries in vivo.

Methods: Twenty-six healthy non-smokers and 23 healthy moderate smokers were recruited in this study. The dorsal hand vein compliance technique and flow-mediated dilation were used.

Matrix metalloproteinase-2 may be involved with increased bone loss associated with experimental periodontitis and smoking: a study in rats.

Background: Smoking has been associated with periodontitis severity and is considered a risk factor for its development. It has been reported that matrix metalloproteinase (MMP) produced by host cells plays a major role in periodontal tissue destruction. Thus, the present study tested, in rats, the hypothesis that local increased levels of MMP-2 would be associated with the enhanced periodontitis-related bone loss after intermittent cigarette smoke inhalation (CSI).

Guided bone regeneration may be negatively influenced by nicotine administration: a histologic study in dogs.

Background: A series of animal and in vitro data confirms that nicotine impairs bone healing, diminishes osteoblast function, and causes autogenous bone graft morbidity. Therefore, this study aimed to investigate the impact of nicotine on the healing of bone defects treated by the guided bone regeneration (GBR) principle.

Methods: Sixteen mongrel dogs were used.

A comparative study on the effect of nicotine administration and cigarette smoke inhalation on bone healing around titanium implants.

Background: A series of isolated studies has focused on the influence of smoking on bone around titanium implants. This study proposes to investigate the impact of two conditions, i.e.