Failure of pure 1-naphthylamine to induce bladder tumors in dogs.

1-Naphthylamine was administered p.o. to beagles for approximately 9 years at a daily dose of 15 mg/kg (5 days a week).

Di(4-aminophenyl)-methane (MDA): 4-7 year dog feeding study.

9 pure bred female beagles ingested purified or crude MDA (in 70 mg doses on 3 days of the week) over periods ranging from 3 years, 11 months to 7 years, 2 months. Total quantities of MDA ingested ranged from 39.98 g to 66.

Liver cancer deaths in the continental USA from 1930 to 1972.

Since 1944 the general U.S. population has been absorbing organochlorine pesticides, which have recently been largely banned because of a concern that they would cause or contribute to the production of liver cancer.

Determination of organochlorine pesticides in the tissues of the black mullet (Mugil cephalus) and the silver mullet (Mugil curema).

The black or silver mullet is a suitable fish for determining the degree and type of local water pollution. In contrast to the great barracuda which we studied earlier, mullet did not lose significant quantities of body fat and DDT-type pesticides at the expense of the developing gonads.

Dieldrin and DDT in the tissues of mice fed aldrin and DDT for seven generations.

Seven-Generation Study (P-F6): The concentration and total retention of dieldrin or p,p'-DDT and metabolites were determined in the total carcass of Swiss-Webster mice fed dietary supplements of aldrin 5 or 10 ppm, or DDT 100 ppm, to age 260 days. All groups showed a significant increase in total body retention (and concentration) of dieldrin or total DDT in the total carcass of the F1, F2, and F3 generations. Generally, these increases were related directly to increases in total body lipids, when compared with the P generations.

DDT tissue retention: sudden rise induced by the addition of aldrin to a fixed DDT intake.

The oral administration of aldrin to male and female beagles, whose diet already included a fixed, regular oral dosage of DDT, resulted in a dramatic rise in the concentrations of DDT, DDE, and DDD in blood and fat.