Long-term follow-up study on obstructive hypertrophic cardiomyopathy patients treated with disopyramide: evidences of a notable trend in symptom control within a real-world clinical setting.

Background: In obstructive hypertrophic cardiomyopathy (HOCM), disopyramide is used in patients who remain symptomatic despite -blockers or verapamil. However, effectiveness of disopyramide therapy has not been clearly established due to inconsistent definition of responders and the insufficient length of follow-ups reported in literature. To address these shortcomings, we have conducted a retrospective analysis from detailed databases with long follow-up, from two HCM Referral Centers.

Non-Pharmacological Treatment of Heart Failure-From Physical Activity to Electrical Therapies: A Literature Review.

Heart failure (HF) represents a significant global health challenge that is still responsible for increasing morbidity and mortality despite advancements in pharmacological treatments. This review investigates the effectiveness of non-pharmacological interventions in the management of HF, examining lifestyle measures, physical activity, and the role of some electrical therapies such as catheter ablation, cardiac resynchronization therapy (CRT), and cardiac contractility modulation (CCM). Structured exercise training is a cornerstone in this field, demonstrating terrific improvements in functional status, quality of life, and mortality risk reduction, particularly in patients with HF with reduced ejection fraction (HFrEF).

Non-Aqueous Poly(dimethylsiloxane) Organogel Sponges for Controlled Solvent Release: Synthesis, Characterization, and Application in the Cleaning of Artworks.

Polydimethylsiloxane (PDMS) organogel sponges were prepared and studied in order to understand the role of pore size in an elastomeric network on the ability to uptake and release organic solvents. PDMS organogel sponges have been produced according to sugar leaching techniques by adding two sugar templates of different forms and grain sizes (a sugar cube template and a powdered sugar template), in order to obtain materials differing in porosity, pore size distribution, and solvent absorption and liquid retention capability. These materials were compared to PDMS organogel slabs that do not contain pores.

Real-world candidacy to mavacamten in a contemporary hypertrophic obstructive cardiomyopathy population.

Aims: In the EXPLORER-HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients. We sought to define the potential use of mavacamten by comparing real-world HOCM patients with those enrolled in EXPLORER-HCM and assessing their eligibility to treatment.

Methods And Results: We collected information on HOCM patients followed up at 25 Italian HCM outpatient clinics and with significant LVOTO (i.

Safety and efficacy of ranolazine in hypertrophic cardiomyopathy: Real-world experience in a National Referral Center.

Objectives: We assessed the efficacy and safety of ranolazine in real-world patients with hypertrophic cardiomyopathy (HCM).

Background: Ranolazine is an anti-anginal drug that inhibits the late phase of the inward sodium current. In a small prospective trial, ranolazine reduced the arrhythmic burden and improved biomarker profile in HCM patients.

The Role of the Left Atrium: From Multimodality Imaging to Clinical Practice: A Review.

In recent years, new interest is growing in the left atrium (LA). LA functional analysis and measurement have an essential role in cardiac function evaluation. Left atrial size and function are key elements during the noninvasive analysis of diastolic function in several heart diseases.

Performance of innovative nanomaterials for bone remains consolidation and effect on C dating and on palaeogenetic analysis.

An innovative protocol for the consolidation of ancient bone remains based on the use of nanometric HydroxyAPatite (HAP) was set up and tested through a multidisciplinary approach. A new protocol for the synthesis of HAP nanoparticles was developed, and the composition of the obtained nanomaterial was investigated through Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Diffraction (XRD); sizes, shape and morphology of the synthesized particles were studied by Scanning Electron Microscopy (SEM). The consolidation performance was evaluated by testing the new nanomaterial on degraded ancient bone findings.

The Treatment of Heart Failure in Patients with Chronic Kidney Disease: Doubts and New Developments from the Last ESC Guidelines.

Patients with heart failure (HF) and associated chronic kidney disease (CKD) are a population less represented in clinical trials; additionally, subjects with more severe estimated glomerular filtration rate reduction are often excluded from large studies. In this setting, most of the data come from post hoc analyses and retrospective studies. Accordingly, in patients with advanced CKD, there are no specific studies evaluating the long-term effects of the traditional drugs commonly administered in HF.

Cardiac involvement in eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): Prospective evaluation at a tertiary referral centre.

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis. Cardiac specific involvement (CSI) is caused by coronary artery vasculitis, but also by myocardial eosinophilic infiltration. To date, the prevalence of CSI associated with EGPA is unresolved.

Efficacy of , decoction with processed in the management of ovarian cyst - A pilot study.

Background: Ovarian cyst is an emerging problem among the women of reproductive age group. Most of the ovarian cyst (80%-85%) are benign, and two-thirds of these occur in women between 20 and 44 years of age. They may be identified in asymptomatic women during routine pelvic examination or may produce symptoms.

Indoor levels of volatile organic compounds at Florentine museum environments in Italy.

Indoor Air Quality monitoring in cultural institutions is of particular concern to protect these places and the cultural heritage content. An indoor monitoring campaign was performed in three museums in Florence (Italy) to determine the occurrence and levels of volatile organic compounds (VOCs). VOCs of interest included BTEX (benzene, toluene, ethylbenzene, xylenes), terpenes, aldehydes, organic acids, and cyclic volatile methyl siloxanes (cVMS).

Effect of and ( Linn.) seed powder in the management of female infertility () due to anovulatory factor: An open-labelled randomized clinical trial.

Back Ground: Infertility is a global problem that has impact on quality of life, especially through the negative psycho-social consequences. One-third of infertile population attending infertility clinics are reported with anovulation. According to Acharya Sushruta, among four essential factors required for conception, (ovum) is the core stone of the female reproductive process and conception can not be achieved in its absence, despite of other factors.

First evidence of microplastic ingestion by fishes from the Amazon River estuary.

This study investigated occurrence of microplastic particles in digestive tracts of fishes from the Amazon River estuary. A total of 189 fish specimens representing 46 species from 22 families was sampled from bycatch of the shrimp fishery. Microplastic particles removed from fish gastrointestinal tracts were identified using Attenuated Total Reflectance - Fourier Transform Infrared (ATR-FTIR).

Structural, rheological and dynamics insights of hydroxypropyl guar gel-like systems.

A dynamic, rheological, and structural characterization of aqueous gel-like systems containing hydroxypropyl guar gum (HPG), borax and glycerol is presented in this paper. The role of glycerol, which is introduced as a plasticizer in the formulation, is investigated by means of B NMR and H NMR PGSTE measurements in order to clarify its contribution to the gel network formation and its interaction with borax, with whom it forms a complex. The effect of gels components on the rheological behaviour and on the activation energy related to the relaxation process of the system was assessed by means of rheology.

Management of premature contractions with - A Case Report.

Premature contraction of the uterus is the very first sign of premature labour, which is followed by progressive changes in cervix such as effacement and dilatation. Four or more uterine contractions with or without pain per hour is a major biophysical predictor of preterm labour. According to the WHO statistics, every year, an estimated 15 million babies are born preterm and this number is rising.

Measurement of volatile organic compounds (VOCs) in libraries and archives in Florence (Italy).

Indoor air samples from libraries and archives in Florence, Italy, were collected and analysed for a variety of volatile organic compounds. The aim was to perform a characterisation of the indoor air quality, and try to elucidate if there are VOCs that may cause or result from the determination of the cultural heritage institutions. All compounds of interest were regularly detected, with BTEXs (Benzene, Toluene, Ethylbenzene, Xylenes) being the most abundant and followed by cyclic volatile methylsiloxanes, aldehydes, terpenes and organic acids.

Specific Anion Effects on the Kinetics of Iodination of Acetone.

Specific ion effects on the kinetics of iodination of acetone in an acidic medium are investigated by UV/Vis spectrophotometry as a function of nature of the acid and temperature. The results indicate that the order of the reaction with respect to acetone is practically unaffected by the composition of the acid while the value of the mixed constant k1 K increases according to the sequence HBr View Article and Find Full Text PDF

Coupling non invasive and fast sampling of proteins from work of art surfaces to surface plasmon resonance biosensing: Differential and simultaneous detection of egg components for cultural heritage diagnosis and conservation.

Despite the wide application of surface plasmon resonance (SPR) to a broad area of interests, from environment to food analysis, from drug discovery to diagnostics, its exploitation in cultural heritage conservation is still unexplored. Water-based highly viscous polymeric dispersions (HVPD) composed by partially hydrolyzed polyvinyl acetate (PVA), borax, and water, were recently developed and successfully applied for the selective removal of surface degradation patinas (i.e.

- An effective local treatment for (vulvovaginitis during pregnancy): A standard controlled randomized clinical trial.

Background: Pregnant women are more prone to vulvovaginitis which is a great challenge for obstetricians today. In , described by , , and both can be compared to vulvovaginitis during pregnancy.

Aims: The present study aimed to evaluate efficacy of in the management of (vulvovaginitis during pregnancy).

Structure and rheology of gel nanostructures from a vitamin C-based surfactant.

The structure and rheology behaviour of gels produced by water dispersions of a vitamin C-derived surfactant (ascorbyl-6-O-dodecanoate) were investigated by means of SAXS and rheology experiments for the first time. The gel state is formed upon heating and is due to an anisotropic expansion of the tightly compact lamellar structure. The phase transition involves primarily the melting of the alkyl chains and a significant increment in the interlamellar water layer.

Controlled graphene oxide assembly on silver nanocube monolayers for SERS detection: dependence on nanocube packing procedure.

Hybrid graphene oxide/silver nanocubes (GO/AgNCs) arrays for surface-enhanced Raman spectroscopy (SERS) applications were prepared by means of two procedures differing for the method used in the assembly of the silver nanocubes onto the surface: Langmuir-Blodgett (LB) transfer and direct sequential physisorption of silver nanocubes (AgNCs). Adsorption of graphene oxide (GO) flakes on the AgNC assemblies obtained with both procedures was monitored by quartz crystal microbalance (QCM) technique as a function of GO bulk concentration. The experiment provided values of the adsorbed GO mass on the AgNC array and the GO saturation limit as well as the thickness and the viscoelastic properties of the GO film.

Efficacy of Yavakshara Taila Uttarabasti in the management of fallopian tube blockage.

Introduction: Tubal blockage is one of the most common causative factors for female barrenness. It accounts for about 25-35% of female infertility. It is very difficult to manage, as the treatment choices for it are only tubal re-constructive surgery and in vitro fertilization (IVF).

Hofmeister effect of anions on calcium translocation by sarcoplasmic reticulum Ca(2+)-ATPase.

The occurrence of Hofmeister (specific ion) effects in various membrane-related physiological processes is well documented. For example the effect of anions on the transport activity of the ion pump Na(+), K(+)-ATPase has been investigated. Here we report on specific anion effects on the ATP-dependent Ca(2+) translocation by the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA).

Synergy of Cobalt and Silver Microparticles Electrodeposited on Glassy Carbon for the Electrocatalysis of the Oxygen Reduction Reaction: An Electrochemical Investigation.

The combination of two different metals, each of them acting on different steps of the oxygen reduction reaction (ORR), yields synergic catalytic effects. In this respect, the electrocatalytic effect of silver is enhanced by the addition of cobalt, which is able to break the O-O bond of molecular oxygen, thus accelerating the first step of the reduction mechanism. At the same time, research is to further reduce the catalyst's cost, reducing the amount of Ag, which, even though being much less expensive than Pt, is still a noble metal.