Chinese Expert Consensus for Assessment of Vocal Function (2024): Guidelines of the Subspecialty Group of Voice, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association; Subspecialty Group of Laryngopharyngology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery.

The assessment of vocal function plays an important role in the diagnosis of voice disorders. With the continuous development of voice medicine in China, the evaluation, diagnosis, and treatment of voice disorders are gradually professionalized and standardized. Experts of the Subspecialty Group of Voice, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association; Subspecialty Group of Laryngopharyngology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery reached the expert consensus through clinical research, literature search, and quality evaluation, as well as two meetings and two rounds of questionnaire voting.

The Application and Efficacy of Voice Therapy and Closed Reduction Under Local Anesthesia Combination for Arytenoid Dislocation.

Objective: To explore the efficacy of voice therapy combined with closed reduction under local anesthesia upon arytenoid dislocation (AD) and to provide new reference for the clinical treatment of AD.

Methods: Fifty-eight patients diagnosed with unilateral AD were enrolled in the study, which were divided into the closed reduction group under local anesthesia alone (25 cases) and the closed reduction group under local anesthesia combined with voice therapy (33 cases) according to the treatment regimen. The vocal cord movements of the two groups were observed under laryngoscopy before and after treatment.

A General Survey of Pharynlaryngeal Diseases and Voice Disorders Among Basic Education Teachers in Tianjin.

Objective: In this study, we created a city-wide database of pharynlaryngeal diseases and voice disorders among basic education teachers to analyze the incidence, distribution, and risk factors of pharynlaryngeal diseases and voice disorders.

Methods: A total of 47,823 teachers in primary and secondary schools and kindergartens of Tianjin were enrolled in this study and underwent questionnaires and throat examinations. In addition, the data were subjected to descriptive statistics, chi-square analysis, and univariate and multivariate logistic regression analyses.

PVR-Vocoder: A Pathological Voice Repair Vocoder for Voice Disorders.

Vocoder-based speech synthesis has become a promising technique to accommodate the demands of high-quality speech analysis, manipulation, and synthesis. However, most existing works focus on how to synthesize normal human voice with high signal-to-noise ratio, neglecting individuals' pathological voice disorder in speech interaction. In this work, we propose a non-linear voice repair vocoder for pathological vowels and sentences, which takes the pathological speech as input and generates high-quality repaired speech.

GBNF-VAE: A Pathological Voice Enhancement Model Based on Gold Section for Bottleneck Feature With Variational Autoencoder.

Objective: Speech enhancement has become a promising technique to accommodate demands of the improvement in quality of a degraded speech signal. The main works now focus on separating normal speech from noise, but have neglected the low quality of impaired speech influenced by anomalous glottis flow. In order to effectively enhance the pathological speech, it is essential to design a separation mechanism for extracting high-dimensional timbre features and speech features separately to suppress low-dimensional noises.

HAGLROS knockdown restrained cell proliferation, migration and invasion and facilitated apoptosis in laryngeal cancer via miR-138-5p/CLN5 axis.

Background: This work investigated the role of HAGLROS in laryngeal cancer (LC).

Methods: HAGLROS expression in the head and neck squamous cell carcinoma (HNSC), target miRNAs of HAGLROS, target mRNAs of miR-138-5p, and the binding sites of HAGLROS and miR-138-5p or CLN5 and miR-138-5p were predicted through bioinformatics. HAGLROS, miR-138-5p, CLN5, Bcl-2, and Bax levels were detected by qRT-PCR and Western blot.

Chaos Behavior Analysis of Alaryngeal Voices Including Esophageal and Tracheoesophageal Voices.

Hypothesis/objectives: This study's objective was to develop a method to evaluate the chaotic characteristic of alaryngeal speech. The proposed method will be capable of distinguishing between normal and alaryngeal voices, including esophageal (SE) and tracheoesophageal (TE) voices. It has been previously shown that alaryngeal voices exhibit chaotic characteristics due to the aperiodicity of their signals.

Lipid-Polymer Hybrid Nanoparticle-Based Combination Treatment with Cisplatin and EGFR/HER2 Receptor-Targeting Afatinib to Enhance the Treatment of Nasopharyngeal Carcinoma.

Purpose: Nasopharyngeal carcinoma (NPC) is one of the most prevalent carcinomas among the Cantonese population of South China and Southeast Asia (responsible for 8% of all cancers in China alone). Although concurrent platinum-based chemotherapy and radiotherapy have been successful, metastatic NPC remains difficult to treat, and the failure rate is high.

Methods: Thus, we developed stable lipid-polymer hybrid nanoparticles (NPs) containing cisplatin (CDDP) and afatinib (AFT); these drugs act synergistically to counter NPC.

Hsa_circ_0057481 promotes laryngeal cancer proliferation and migration by modulating the miR-200c/ZEB1 axis.

As a new type of non-coding RNA, circular RNAs (circRNAs) have been reported to be important regulators of tumor initiation and progression. By using the high-throughput microarray, a recent study demonstrated that the expression of hsa_circ_0057481 is upregulated in human laryngeal cancer. In the present study, we aimed to elucidate the role of hsa_circ_0057481 in laryngeal cancer.