Ribosomal proteins are blood biomarkers and associated with CD4+ T cell activation in Alzheimer's disease: a study based on machine learning strategies and scRNA-Seq data validation.

Background: Alzheimer's disease (AD) is a widespread neurodegenerative disease that primarily affects the elderly. Unfortunately, the lack of convenient early diagnostic tools makes it difficult to intervene and treat the disease during its initial stages.

Methods: We obtained four bulk and single-cell RNA-sequencing peripheral blood samples related to AD from public databases.