Publications by authors named "Dehua Yang"

Aptamers, functional nucleic acids recognized for their high target-binding affinity and specificity, have been extensively employed in biosensors, diagnostics, and therapeutics. Conventional screening methods apply evolutionary pressure to optimize affinity, while counter-selections are used to minimize off-target binding and improve specificity. However, aptamer specificity characterization remains limited to target analogs and experimental controls.

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Two new tetraene lactone derivatives ( and ), two new α-pyrone derivatives ( and ), three compounds reported as natural products for the first time [an α-pyrone derivative (), an indole-diketopiperazine alkaloid (), and a β-amino acid derivative ()], and 11 known compounds (, -), were obtained from microorganisms isolated from hadal trench sediments in the Pacific Ocean. Their structures were determined using NMR, HRESIMS, optical rotatory dispersion (ORD) spectra, NMR calculations followed by DP4+ analysis, electronic circular dichroism (ECD) calculations, X-ray crystallography analysis, and advanced Marfey's and modified Mosher eater methods. Microbial broth dilution assay suggested that compounds - and had weak antibacterial effects.

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Objective: Alternative splicing affects gene expression during placental development. The present study aimed to identify poly (ADP-ribose) polymerase 1 (PARP1)-regulated alternative splicing events in HTR-8/Svneo cells.

Methods: Decidual tissues were collected from women with induced abortion and spontaneous abortion.

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Seven novel linear polyketides, talaketides A-G (1-7), were isolated from the rice media cultures of the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027. Among these, talaketides A-E (1-5) represented unprecedented unsaturated linear polyketides with an epoxy ring structure.

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For the first time, polystyrene sulfonic acid solution (PSS) was observed to emit blue fluorescence. The photoluminescence (PL) behavior of PSS under different concentrations, pH values and magnetic field strengths was investigated, revealing the diversity and tunability of its PL properties. PSS possesses remarkable down-conversion properties and strong responsiveness to external magnetic fields.

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Passivation technology is crucial for reducing interface defects and impacting the performance of crystalline silicon (c-Si) solar cells. Concurrently, maintaining a thin passivation layer is essential for ensuring efficient carrier transport. With an ultrathin passivated contact structure, both Silicon Heterojunction (SHJ) cells and Tunnel Oxide Passivated Contact (TOPCon) solar cells achieve an efficiency surpassing 26%.

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Background: Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) poses a considerable challenge to patients and their families due to its severe complications. Previous researches have highlighted the critical role of immune disorders in its pathogenesis. However, fragmented studies based on isolated cases hinder a comprehensive understanding of this deadly illness.

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Article Synopsis
  • Histological grading is critical for predicting outcomes, guiding treatment, and evaluating recurrence in non-functional pancreatic neuroendocrine tumors (NF-Pan-NET), with better prognosis in patients lacking copy number variation (CNV).
  • The study examined tumor cell heterogeneity based on genomic instability and histological grading, uncovering significant differences in the activated core pathways.
  • Key immune cells, such as lymphatic endothelial cells, macrophages, and Treg cells, were identified as contributors to hepatic metastases, enhancing the understanding of NF-Pan-NET's malignant potential.
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Obesity and type 2 diabetes mellitus (T2DM) impact more than 2.5 billion adults worldwide, necessitating innovative therapeutic approaches. Unimolecular polypharmacology, which involves designing single molecules to target multiple receptors or pathways simultaneously, has revolutionized treatment strategies.

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  • - The study investigated how the presence of Mycoplasma pneumoniae (MP) in pleural effusions affects children with Mycoplasma pneumoniae pneumonia (MPP), finding that children with MP-positive effusions had longer hospital stays and illness durations than those without MP.
  • - Children with MP-positive pleural effusions were more likely to experience complications such as pericardial effusion, atelectasis, and necrotizing pneumonia compared to those in the MP-negative group.
  • - Various clinical markers (neutrophil levels, C-reactive protein, procalcitonin, serum lactate dehydrogenase, and D-dimer) were significantly higher in the MP-positive group, helping to distinguish M
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Mahvash disease, a rare autosomal recessive metabolic disorder characterized by biallelic loss-of-function mutations in the glucagon receptor gene (), induces significant pancreatic hyperglucagonemia, resulting in α-cell hyperplasia and occasional hypoglycemia. Utilizing CRISPR-Cas9 technology, we engineered a mouse model, designated as , harboring a homozygous V369M substitution in the glucagon receptor (GCGR). Although wild-type (WT) and mice exhibited no discernible difference in appearance or weight, adult mice, approximately 12 months of age, displayed a notable decrease in fasting blood glucose levels and elevated the levels of cholesterol and low-density lipoprotein-cholesterol.

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For segmented telescopes, achieving fine co-focus adjustment is essential for realizing co-phase adjustment and maintenance, which involves adjusting the millimeter-scale piston between segments to fall within the capture range of the co-phase detection system. CGST proposes using a SHWFS for piston detection during the co-focus adjustment stage. However, the residual piston after adjustment exceeds the capture range of the broadband PSF phasing algorithm( ± 30μm), and the multi-wavelength PSF algorithm requires even higher precision in co-focus adjustment.

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  • Conventional type 1 dendritic cells are vital for antitumor immunity, and inhibiting BCL9/BCL9L can enhance immune responses and slow tumor growth.
  • Targeting BCL9/BCL9L leads to better antigen presentation in tumors by activating cDC1 and promoting their infiltration, as evidenced by the use of a novel inhibitor and knockout models.
  • Single-cell transcriptomics analysis reveals that cDC1 lacking Bcl9/Bcl9l are more effective in activation and antigen presentation, suggesting that manipulating BCL9/BCL9L could improve cancer immunotherapy outcomes.
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The noradrenaline transporter has a pivotal role in regulating neurotransmitter balance and is crucial for normal physiology and neurobiology. Dysfunction of noradrenaline transporter has been implicated in numerous neuropsychiatric diseases, including depression and attention deficit hyperactivity disorder. Here we report cryo-electron microscopy structures of noradrenaline transporter in apo and substrate-bound forms, and as complexes with six antidepressants.

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There is limited research on the association between the alanine aminotransferase to high-density lipoprotein cholesterol ratio (ALT/HDL-C) ratio and nonalcoholic fatty liver disease (NAFLD). The purpose of the current research was to look into the connection between the ALT/HDL-C ratio and the risk of NAFLD in lean Chinese individuals. Between January 2010 and December 2014, 11,975 non-obese people participated in this prospective cohort research.

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Ferroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation of lipids within cellular membranes. Ferroptosis plays a crucial role in physiological and pathological situations and has attracted the attention of numerous scientists. Ferroptosis suppressive protein 1 (FSP1) is one of the main regulators that negatively regulates ferroptosis through the GPX4-independent FSP1-CoQ10-NAD(P)H axis and is a potential therapeutic target for ferroptosis-related diseases.

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Objectives: The present body of evidence regarding the correlation between the estimated glomerular filtration rate (eGFR) and the reversal of impaired fasting glucose (IFG) to normoglycemia remains constrained. Consequently, the objective of our study is to examine the relationship between eGFR and the restoration of normoglycemia in individuals with IFG.

Methods: This retrospective cohort study consecutively collected data from 24,541 non-selective participants with IFG at Rich Healthcare Group in China from January 2010 to 2016.

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