CircPCNXL2 promotes papillary thyroid carcinoma progression by regulating fatty acid metabolism induced by anabolic enzyme ACC1.

Papillary thyroid cancer (PTC) is an endocrine malignant tumor with a rapidly increasing incidence in recent years. Although the disease prognosis is good in general, there are still some patients with local invasion, distant metastasis and recurrence, which make treatment difficult. This study aimed to investigate the effect of a novel circRNA, circPCNXL2, on the progression of PTC and to explore its underlying mechanism in PTC.

Gasless submental-transoral combined approach endoscopic thyroidectomy: a new surgical technique.

Background: The development of transoral endoscopic vestibular approach thyroidectomy (TOETVA) has been limited by inherent defects, such as mental nerve injury and carbon dioxide (CO)-related complications. Herein, we proposed a new technique without CO called gasless submental-transoral combined approach endoscopic thyroidectomy (STET) to solve the problems in TOETVA.

Methods: We reviewed 75 patients who successfully underwent gasless STET using novel instruments at our institution from November 2020 to November 2021.

Novel suspension system for gasless transoral vestibular thyroidectomy.

Background: The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is receiving increased attention, frequently due to growing requirements for cosmetic incisions. Here, we report our initial experience and discuss the safety and efficacy of the innovative surgical working space suspension system for gasless TOETVA.

Methods: We retrospectively analyzed 75 consecutive patients for whom gasless TOETVA with our novel working space suspension system was used.

Autologous parathyroid gland in left-brachioradialis transplantation: A single-center study and long-term follow-up.

Unlabelled: Parathyroid gland transplantation into the sternocleidomastoid muscle is effective, but it is not possible to confirm transplant survival with this method. In this study, we evaluated parathyroid autotransplantation into the brachioradialis muscle and its survival rate.

Objectives: To evaluate autologous parathyroid gland left forearm brachioradial muscle transplantation and its survival rate.

2D/2D Interface Engineering Promotes Charge Separation of MoC/g-CN Nanojunction Photocatalysts for Efficient Photocatalytic Hydrogen Evolution.

The focus of designing and synthesizing composite catalysts with high photocatalytic efficiency is the regulation of nanostructures and optimization of heterojunctions. By increasing the contact area between the catalysts, additional reaction sites can be established and charge carriers can be transferred and reacted faster. Here, two-dimensional (2D) MoC is prepared via a novel approach by carbonizing precursors intercalated by low-boiling solvents, and a composite catalyst MoC/graphitic carbon nitride (g-CN) with 2D to 2D structure optimization was synthesized through the self-assembly of 2D MoC and 2D g-CN.

CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway.

Papillary thyroid cancer (PTC) is a common endocrine tumor with a rapidly increasing incidence in recent years. Although the majority of PTCs are relatively indolent and have a good prognosis, a certain proportion is highly aggressive with lymphatic metastasis, iodine resistance, and easy recurrence. Circular RNAs (circRNAs) are a class of noncoding RNAs that are linked to a variety of tumor processes in several cancers, including PTC.

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression.

Osteosarcoma is the most common primary malignant bone tumor in adolescents. While chemotherapy combined with surgery can improve the prognosis of some patients, chemo-resistance is still a huge obstacle in osteosarcoma treatment. Accumulating evidence demonstrates that circular RNAs (circRNAs) are involved in cancer progression and metastasis, but their specific role in osteosarcoma remains mostly undescribed.

Circular RNA circRUNX1 promotes papillary thyroid cancer progression and metastasis by sponging MiR-296-3p and regulating DDHD2 expression.

Papillary thyroid cancer (PTC) has a continuously increasing incidence and imposes a heavy medical burden to individuals and society due to its high proportion of lymph node metastasis and recurrence in recent years. Circular RNAs, a class of noncoding RNAs, participate in the progression of many cancers, but the role of circRNAs in PTC is still rarely reported. In this study, circRNA deep sequencing was performed to identify differentially expressed circRNAs in PTC.

A NOVEL SCORING SYSTEM FOR THE RISK OF PAPILLARY THYROID CANCER METASTASES IN LYMPH NODES POSTERIOR TO THE RIGHT OF THE RECURRENT LARYNGEAL NERVE.

Objective: Some surgeons believe that dissection posterior to the right recurrent laryngeal nerve lymph node (PRRLN-LN) is unnecessary for the low metastasis rate and high complication risk. However, persistent metastatic lymph nodes may have a higher recurrence rate, surgical risk, and complications. Thus, it is important to distinguish patients who require PRRLN-LN dissection.

CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc.

Background: Osteosarcoma (OS) is the most common malignant bone tumor and has a poor prognosis. The potential involvement of circular RNAs (circRNAs) in OS progression remains unexplored. Here, we report that CircECE1, a circular RNA derived from human ECE1, plays a critical role in energy metabolism in OS.

Synthesis of narrow-band curled carbon nitride nanosheets with high specific surface area for hydrogen evolution from water splitting by low-temperature aqueous copolymerization to form copolymers.

Carbon nitride has become a focus of photocatalytic materials research in recent years, but the low specific surface area, the bad separation efficiency of photocarriers, poor quantum efficiency, terrible photocatalytic activity hinder the development of carbon nitride in the field of photocatalysis. The preparation of carbon nitride nanosheets is one of the effective methods to improve the photocatalytic efficiency of carbon nitride, but the traditional top-down stripping process is time-consuming, complicated and expensive. Here we report a simple, cheap, non-toxic and environmentally friendly bottom-up method to prepare a curled g-CN nanosheet (NS-CN), which is performed at low temperature and normal pressure.

Prognostic values of m6A RNA methylation regulators in differentiated Thyroid Carcinoma.

N6-methyladenosine (m6A) is the most prevalent modification of RNA in mammals. m6A RNA methylation levels are dynamically regulated by m6A RNA methylation regulators. While increasing evidence has suggested that m6A RNA methylation is vital in the initiation and progression of human carcinoma, little is known about the expression and effect of m6A RNA methylation regulators in differentiated thyroid carcinoma (DTC).

Lymph node metastasis in the space between the right carotid artery and jugular vein in papillary thyroid carcinoma.

Background: The oblique brachiocephalic trunk and right common carotid artery constitute the right carotid sheath space (RCSS). The aim of this study was to detect the clinicopathologic factors associated with RCSS lymph node metastasis.

Methods: In total, 232 papillary thyroid carcinoma (PTC) patients with preoperative contrast-enhanced computed tomography scans were analyzed for associations between RCSS lymph node metastasis and clinicopathological factors.

Identifying risk factors for metastasis to the level VII lymph node in papillary thyroid carcinoma patients.

Background: The level VI lymph nodes are anatomically connected to the level VII lymph nodes and papillary thyroid carcinoma (PTC) can metastasis to both regions. The aim of this study was to identify clinicopathologic factors associated with level VII lymph node metastasis.

Methods: Between March 2015 and September 2016, a total of 275 consecutive patients were operated on for PTC with prophylactic level VII dissection at the Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, ZheJiang, China.

Low expression of ryanodine receptor 2 is associated with poor prognosis in thyroid carcinoma.

Genetic alterations are vital in the progression of thyroid carcinoma. Ryanodine receptor 2 (RyR2) is reported to serve an important role in several types of human carcinoma. However, the expression and effect of RyR2 in thyroid carcinoma remain unknown.

Effects of dietary sorghum dried distiller's grains with solubles on growth performance, diet nutrient digestibility, carcass characteristics and immunity in growing rabbits.

Sorghum dried distiller's grains with solubles (S-DDGS) are distillation extract residues from the ethanol fuel industry. In this experiment, two hundred 42-day-old rabbits were randomly allocated to five experimental diets containing 0 g/kg (control), 75, 150, 225 and 300 g/kg S-DDGS. The experiment lasted for 4 weeks.

Predictors of graft function after parathyroid autotransplantation during thyroid surgery.

Background: The purpose of this study was to identify predictors associated with graft function after parathyroid autotransplantation during thyroid surgery.

Methods: One hundred fifty patients who underwent thyroid surgery with parathyroid autotransplantation were enrolled prospectively. During surgery, the misresected or devascularized parathyroid gland was autografted in the brachioradialis muscle of the forearm.

Comparison Between Video-Assisted and Open Lateral Neck Dissection for Papillary Thyroid Carcinoma with Lateral Neck Lymph Node Metastasis: A Prospective Randomized Study.

Background: The safety and oncologic completeness of video-assisted lateral neck dissection (VALND) for papillary thyroid carcinoma (PTC) with lateral neck lymph node metastasis (LNM) have been reported. However, their generalization has remained limited because the advantages and drawbacks are not well demonstrated.

Materials And Methods: A total of 64 patients with PTC and unilateral lateral neck LNM who underwent total thyroidectomy with central compartment neck dissection and lateral neck dissection (LND) were prospectively enrolled.

A comparative study of the surgical outcomes between video-assisted and open lateral neck dissection for papillary thyroid carcinoma with lateral neck lymph node metastases.

Purpose: Video-assisted lateral neck dissection (VALND) for papillary thyroid carcinoma (PTC) with lateral neck lymph node metastases (LNM) has been described previously, however, the advantages and drawbacks of VALND have not been demonstrated in previous studies. The aim of this study was to compare the surgical outcomes of video-assisted and open lateral neck dissection for PTC with lateral neck LNM.

Materials And Methods: Between May 2013 and November 2014, 92 consecutive patients with PTC and lateral neck lymph node metastases underwent total thyroidectomy with central compartment neck dissection and unilateral lateral neck dissection.

Risk factors for posterior to right recurrent laryngeal nerve lymph node metastasis in papillary thyroid carcinoma.

Objectives: To identify the risk factors for posterior right recurrent laryngeal nerve lymph node metastasis (PRRLN-LNM) in papillary thyroid carcinoma (PTC).

Methods: We conducted a retrospective study of 389 patients with primary PTC who underwent right lobectomy or total thyroidectomy, and comprehensive right or bilateral central compartment dissection (CCD) with or without lateral neck dissection (LND) between January 2010 and May 2013 at the Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of Zhejiang University, Zhejiang, China. The clinicopathological findings were investigated, and relative risk factors for PRRLN-LNM were analyzed.

Minimally invasive endoscopic-assisted resection of benign tumors in the accessory parotid gland: 5 case studies.

Background: A modified Blair's incision or standard facelift incision is recommended to remove tumors in the accessory parotid gland. These incisions frequently result in long and visible scars. Therefore, the authors have introduced an endoscopic approach via a small preauricular incision to achieve excision of benign tumors in the accessory parotid gland.

[Improvement of immunogenicity of Streptococcus pneumoniae psaA DNA vaccine by prime and boost strategy].

Objective: To study on the preparation of Streptococcus pneumoniae psaA DNA vaccine and to analyse the immunogenicity by the prime-boost strategy.

Methods: The psaA gene was amplified from the genome of Streptococcus pneumoniae by PCR, and then was inserted into plasmid pVAX1 and pET28a to construct recombinant expression vectors respectively. 293T cells were transiently transfected with pVAX1-psaA, and RT-PCR analysis of total cell RNA extracts showed successful expression of psaA.